Institutional Protocol to Manage Consanguinity Detected by Genetic Testing in Pregnancy in a Minor
Single-nucleotide polymorphism arrays and other types of genetic tests have the potential to detect first-degree consanguinity and uncover parental rape in cases of minor teenage pregnancy. We present 2 cases in which genetic testing identified parental rape of a minor teenager. In case 1, single-nucleotide polymorphism array in a patient with multiple developmental abnormalities demonstrated multiple long stretches of homozygosity, revealing parental rape of a teenage mother. In case 2, a vague maternal sexual assault history and diagnosis of Pompe disease by direct gene sequencing identified parental rape of a minor. Given the medical, legal, and ethical implications of such revelations, a protocol was developed at our institution to manage consanguinity identified via genetic testing.
- single nucleotide polymorphism
- pregnancy in adolescence
- genetic testing
- DNA sequence analysis
- Accepted December 8, 2014.
- Copyright © 2015 by the American Academy of Pediatrics