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    Pediatrics
    August 2013
    From the American Academy of Pediatrics
    Article

    Bisphenol A and Chronic Disease Risk Factors in US Children

    Donna S. Eng, Joyce M. Lee, Achamyeleh Gebremariam, John D. Meeker, Karen Peterson, Vasantha Padmanabhan
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    Abstract

    OBJECTIVE: To evaluate the relationship between urinary bisphenol A (BPA) levels and measures of adiposity and chronic disease risk factors for a nationally representative US pediatric sample.

    METHODS: We used the NHANES 2003–2010 to evaluate cross-sectional associations between urinary BPA and multiple measures of adiposity, cholesterol, insulin, and glucose for children aged 6 to 18 years, adjusting for relevant covariates (eg, demographics, urine creatinine, tobacco exposure, and soda consumption).

    RESULTS: We found a higher odds of obesity (BMI ≥95th percentile) with increasing quartiles of BPA for quartiles 2 vs 1 (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.17–2.60, P = .008), 3 vs 1 (OR 1.64, 95% CI 1.09–2.47, P = .02), and 4 vs 1 (OR 2.01, 95% CI 1.36–2.98, P = .001). We also found a higher odds of having an abnormal waist circumference–to–height ratio (quartiles 2 vs 1 [OR 1.37, 95% CI 0.98–1.93, P = .07], 3 vs 1 [OR 1.41, 95% CI 1.07–1.87, P = .02], and 4 vs 1 [OR 1.55, 95% CI 1.12–2.15, P = .01]). We did not find significant associations of BPA with any other chronic disease risk factors.

    CONCLUSIONS: Higher levels of urinary BPA were associated with a higher odds of obesity (BMI >95%) and abnormal waist circumference–to–height ratio. Longitudinal analyses are needed to elucidate temporal relationships between BPA exposure and the development of obesity and chronic disease risk factors in children.

    • bisphenol A
    • NHANES
    • children
    • obesity
    • endocrine disrupting chemical
  • Abbreviations:
    BPA —
    bisphenol A
    CI —
    confidence interval
    DXA —
    dual-energy radiograph absorptiometry
    HDL —
    high-density lipoprotein
    LDL —
    low-density lipoprotein
    OR —
    odds ratio
    TC —
    total cholesterol
    TG —
    triglycerides
    WC —
    waist circumference
    • Accepted May 31, 2013.
    • Copyright © 2013 by the American Academy of Pediatrics
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    Bisphenol A and Chronic Disease Risk Factors in US Children
    Donna S. Eng, Joyce M. Lee, Achamyeleh Gebremariam, John D. Meeker, Karen Peterson, Vasantha Padmanabhan
    Pediatrics Aug 2013, peds.2013-0106; DOI: 10.1542/peds.2013-0106

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    Bisphenol A and Chronic Disease Risk Factors in US Children
    Donna S. Eng, Joyce M. Lee, Achamyeleh Gebremariam, John D. Meeker, Karen Peterson, Vasantha Padmanabhan
    Pediatrics Aug 2013, peds.2013-0106; DOI: 10.1542/peds.2013-0106
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