Triglyceride to HDL-C Ratio and Increased Arterial Stiffness in Children, Adolescents, and Young Adults
BACKGROUND AND OBJECTIVE: Lipid levels are linked to early atherosclerosis. Risk stratification may be improved by using triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), which relates to arterial stiffness in adults. We tested whether TG/HDL-C was an independent predictor of arterial stiffness in youth.
METHODS: Subjects 10 to 26 years old (mean 18.9 years, 39% male, 56% non-Caucasian, n = 893) had laboratory, anthropometric, blood pressure, and arterial stiffness data collected (brachial distensibility, augmentation index, carotid-femoral pulse-wave velocity). Subjects were stratified into tertiles of TG/HDL-C (low, n = 227; mid, n = 288; high, n = 379).
RESULTS: There was a progressive rise in cardiovascular (CV) risk factors and arterial stiffness across TG/HDL-C ratio. The high TG/HDL-C ratio group had the stiffest vessels (all P < .03 by analysis of variance). TG/HDL-C as a continuous variable was an independent determinant of brachial distensibility in CV risk factor adjusted model and for carotid-femoral pulse-wave velocity in obese subjects, with trend for higher augmentation index.
CONCLUSIONS: TG/HDL-C, an estimate of small, dense low-density lipoprotein cholesterol, is an independent determinant of arterial stiffness in adolescents and young adults, especially in obese youth. These data suggest that use of TG/HDL-C may be helpful in identifying young adults requiring aggressive intervention to prevent atherosclerotic CV diseases.
- AIx —
- augmentation index
- BP —
- blood pressure
- BrachD —
- brachial artery distensibility
- CRP —
- high-sensitivity C-reactive protein
- CV —
- DBP —
- diastolic BP
- HDL-C —
- high-density lipoprotein cholesterol
- HR —
- heart rate
- LDL-C —
- low-density lipoprotein cholesterol
- MAP —
- mean arterial pressure
- PWV —
- carotid-femoral pulse wave velocity
- T2DM —
- type 2 diabetes mellitus
- TG —
- TG/HDL-C —
- triglyceride to HDL-cholesterol ratio
- Accepted November 27, 2012.
- Copyright © 2013 by the American Academy of Pediatrics