Skip to main content
Skip to main content

AAP Gateway

Advanced Search »

User menu

  • Login
  • Current Policy
  • Topic/Program Collections
  • Submit Manuscript
  • Alerts
  • Subscribe
  • aap.org

Menu

  • AAP Grand Rounds
  • AAP News
  • Hospital Pediatrics
  • NeoReviews
  • Pediatrics
  • Pediatrics in Review
  • Current AAP Policy
  • Journal CME
  • AAP Career Center
  • Pediatric Collections
  • AAP Journals Catalog

Sections

    • Login
    • Current Policy
    • Topic/Program Collections
    • Submit Manuscript
    • Alerts
    • Subscribe
    • aap.org

    Sign up for Insight Alerts highlighting editor-chosen studies with the greatest impact on clinical care.

    New! Video Abstracts -- brief videos summarizing key findings of new articles

    Know what's next when you read AAP Journals, view the new 2018 Catalog.
    Trainees,
    enter the SOPT Essay Contest for a chance to be published in Pediatrics!

    Advertising Disclaimer »

    Tools and Links

    Pediatrics
    October 2011
    From the American Academy of Pediatrics
    Article

    Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children

    Joe M. Braun, Amy E. Kalkbrenner, Antonia M. Calafat, Kimberly Yolton, Xiaoyun Ye, Kim N. Dietrich, Bruce P. Lanphear
    • Article
    • Info & Metrics
    • Comments
    Loading
    Download PDF

    Abstract

    Objectives: To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations.

    Methods: We used a prospective birth cohort of 244 mothers and their 3-year-old children from the greater Cincinnati, Ohio, area. We characterized gestational and childhood BPA exposures by using the mean BPA concentrations in maternal (16 and 26 weeks of gestation and birth) and child (1, 2, and 3 years of age) urine samples, respectively. Behavior and executive function were measured by using the Behavior Assessment System for Children 2 (BASC-2) and the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P).

    Results: BPA was detected in >97% of the gestational (median: 2.0 μg/L) and childhood (median: 4.1 μg/L) urine samples. With adjustment for confounders, each 10-fold increase in gestational BPA concentrations was associated with more anxious and depressed behavior on the BASC-2 and poorer emotional control and inhibition on the BRIEF-P. The magnitude of the gestational BPA associations differed according to child gender; BASC-2 and BRIEF-P scores increased 9 to 12 points among girls, but changes were null or negative among boys. Associations between childhood BPA exposure and neurobehavior were largely null and not modified by child gender.

    Conclusions: In this study, gestational BPA exposure affected behavioral and emotional regulation domains at 3 years of age, especially among girls. Clinicians may advise concerned patients to reduce their exposure to certain consumer products, but the benefits of such reductions are unclear.

    • attention-deficit/hyperactivity disorder
    • child behavior
    • endocrine disruptors
    • prospective study
    • Accepted August 8, 2011.
    • Copyright © 2011 by the American Academy of Pediatrics
    Full Text (PDF)
    Next

     

    Advertising Disclaimer »

    Next
    Email

    Thank you for your interest in spreading the word on Pediatrics.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children
    (Your Name) has sent you a message from Pediatrics
    (Your Name) thought you would like to see the Pediatrics web site.

    Alerts
    Sign In to Email Alerts with your Email Address
    Citation Tools
    Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children
    Joe M. Braun, Amy E. Kalkbrenner, Antonia M. Calafat, Kimberly Yolton, Xiaoyun Ye, Kim N. Dietrich, Bruce P. Lanphear
    Pediatrics Oct 2011, peds.2011-1335; DOI: 10.1542/peds.2011-1335

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    Impact of Early-Life Bisphenol A Exposure on Behavior and Executive Function in Children
    Joe M. Braun, Amy E. Kalkbrenner, Antonia M. Calafat, Kimberly Yolton, Xiaoyun Ye, Kim N. Dietrich, Bruce P. Lanphear
    Pediatrics Oct 2011, peds.2011-1335; DOI: 10.1542/peds.2011-1335
    del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
    PDF
    Insight Alerts
    • Table of Contents
    • Current Policy
    • Early Release
    • Current Issue
    • Past Issues
    • Editorial Board
    • Editorial Policies
    • Overview
    • Open Access
    • Pediatric Collections
    • Video Abstracts
    • Author Guidelines
    • Reviewer Guidelines
    • Submit My Manuscript

    Subjects

    • Medical Education
      • Research Methods & Statistics
      • Medical Education
    Back to top

                

    Copyright (c) 2018 by American Academy of Pediatrics

    International Access »           

    Terms of Use
    Privacy Statement
    FAQ

    AAP Pediatrics