Among the untoward side effects of kanamycin, ototoxicity is particularly frequent. Premature infants may be at increased risk because of their low glomerular filtration rate. Previous studies have revealed decreased sensory neural hearing in 0% to 19% of term and premature infants who received kanamycin. Because only one study specifically investigated this question in premature infants,1 we have performed an audiometric survey in children aged 4 to 10 years (mean 7.5 years) who received kanamycin while premature and in age-matched controls.
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