At its meeting in Washington, D.C., on April 29, 1974, the Committee on Infectious Diseases and representatives of FDA and CDC reviewed this year's (1973-1974) experiences with Reye's syndrome. It is clear that a definite increase in this disease occurred in the United States and that this increase bore a temporal and geographic relation to outbreaks of influenza due to strains of inuenza virus B. Outbreaks of influenza overseas may not have been associated with the syndrome. A small percentage of U.S. cases was associated with other infections, including influenza A and vanicella. Although epidemiologically associated in many instances, a direct cause and effect relationship between influenza B infection and Reye's syndrome has not been established. Pathogenesis of the syndrome remains unclear. Therefore, immunization with influenza B vaccine in an effort to prevent Reye's syndrome is without established basis.
The Center for Disease Control is maintaining continuous epidemiologic surveillance of the syndrome. The Committee on Infectious Diseases urges full cooperation with this effort, as follows: (1) All cases meeting the usual diagnostic criteria (encephalopathy plus liver abnormalities, most often an SGOT twice normal or greater, without other obvious explanation) should be reported to the Viral Diseases Branch, Center for Disease Control, Atlanta, Georgia 30333, either directly or through the state health department. (2) As much pertinent clinical and laboratory data as is consistent with good patient care should be collected and recorded for later transmission to the CDC if requested. Particular attention should be paid to exposure to toxic substances on drugs such as ASA.
- Copyright © 1975 by the American Academy of Pediatrics