The extracellular volume of a group of normal infants, in the first day of life, was measured by means of the corrected bromide space, and was found to be 358 ± 6.5 ml/kg of body weight. There was no consistent variation due to the sex or age of the infants.
No decrease was found in extracellular volume during the period 5 to 15 hours after birth. In the fasting and thirsting newborn one injection of hydrocortisone or desoxy-corticosterone acetate produced no detectable change in the measured bromide space after a mean of 6 and 7½ hours following injection.
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