PURPOSE OF THE STUDY.
The purpose of this study was to characterize the incidence and severity of adverse drug events in a population of medically complex and chronic pediatric patients.
Patients ranging in age from 0 to 18 years presenting to an emergency department (ED) with an adverse drug event.
A national retrospective cohort study, using the National Emergency Department Sample (NEDS) database, analyzed International Classification of Diseases, Ninth Revision, Clinical Modification, diagnosis codes associated with adverse drug events from pediatric ED visits from 2006–2010.
Adverse drug events account for 0.5% of the 144 million ED visits included in this study. Pediatric patients with medically complex and chronic conditions were found to have increased association with ED visits for adverse drug events (odds ratio = 4.76; 95% confidence interval, 4.45–5.10).
Children with more complex and chronic medical conditions were more likely to have ED visits for adverse drug events. However, admission rates were not statistically higher when compared with the general population for adverse drug events.
This is the first study that quantifies the incidence of adverse drug events in a small yet high-risk population of pediatric patients. Although the study did not show a statistically significant higher amount of admissions for adverse drug events in the target population, increased morbidity may exist because adverse drug events are likely to be either undercoded or present with a delayed response that is not reflected in the ED data from the national database. The impending implementation of International Classification of Diseases, Tenth Revision, may facilitate additional study in this area.
- Copyright © 2015 by the American Academy of Pediatrics