PURPOSE OF THE STUDY.
To assess the effect of maternal consumption during pregnancy of dairy foods, calcium, and vitamin D on allergic disorders in Japanese children aged 23 to 29 months.
The study recruited 1354 Japanese mother-child between April 2007 and March 2008, and between 5 and 39 weeks of pregnancy.
Data were obtained using the Kyushu Okinawa Maternal and Child Health Study (KOMCHS), a prospective prebirth cohort study. Participants returned the application form and questionnaires were obtained from patients at obstetric hospitals in Okinawa. Diet history of maternal intake was assessed from April 2007 to March 2008. The questionnaire, completed by the mother, also elicited maternal and paternal history of asthma, atopic dermatitis, and allergic rhinitis.
Infants with mothers in the highest quartile for dairy product ingestion during pregnancy had a significant reduction in the risk of infantile eczema. A reduced risk of physician-diagnosed infantile asthma was significantly associated with higher maternal intake of cheese during pregnancy. Among mothers with yogurt and calcium consumption during pregnancy, physician-diagnosed infantile atopic dermatitis was found to be significantly inversely diagnosed. Increased risk of eczema was seen among mothers with high Vitamin D intake during pregnancy.
Among offspring of mothers with high intake of total dairy products, cheese, yogurt, and calcium during pregnancy, the risk of infantile eczema, physician-diagnosed asthma, and physician-diagnosed atopic eczema may be reduced. There may be an increased risk of infantile eczema associated with higher maternal intake of vitamin D during pregnancy.
Interest in the use of supplements and possible effects on atopy is growing. The significance of exposure during gestation is important in the long-term health of children, as seen in this study. This study raises interesting questions regarding exposure to foods via maternal intake during gestation and later development of atopic disease. Because the use of vitamin D supplementation is increasing, the authors remind us that there may be a risk of infantile eczema, and therefore further studies are warranted.
- Copyright © 2015 by the American Academy of Pediatrics