Tools and Links

Pediatrics
July 2015, VOLUME 136 / ISSUE 1
Special Article

Vascular Anomalies Classification: Recommendations From the International Society for the Study of Vascular Anomalies

Michel Wassef, Francine Blei, Denise Adams, Ahmad Alomari, Eulalia Baselga, Alejandro Berenstein, Patricia Burrows, Ilona J. Frieden, Maria C. Garzon, Juan-Carlos Lopez-Gutierrez, David J.E. Lord, Sally Mitchel, Julie Powell, Julie Prendiville, Miikka Vikkula on behalf of the ISSVA Board and Scientific Committee
Download PDF

Abstract

Vascular anomalies represent a spectrum of disorders from a simple “birthmark” to life- threatening entities. Incorrect nomenclature and misdiagnoses are commonly experienced by patients with these anomalies. Accurate diagnosis is crucial for appropriate evaluation and management, often requiring multidisciplinary specialists. Classification schemes provide a consistent terminology and serve as a guide for pathologists, clinicians, and researchers. One of the goals of the International Society for the Study of Vascular Anomalies (ISSVA) is to achieve a uniform classification. The last classification (1997) stratified vascular lesions into vascular malformations and proliferative vascular lesions (tumors). However, additional disease entities have since been identified that are complex and less easily classified by generic headings, such as capillary malformation, venous malformation, lymphatic malformation, etc. We hereby present the updated official ISSVA classification of vascular anomalies. The general biological scheme of the classification is retained. The section on tumors has been expanded and lists the main recognized vascular tumors, classified as benign, locally aggressive or borderline, and malignant. A list of well-defined diseases is included under each generic heading in the “Simple Vascular Malformations” section. A short definition is added for eponyms. Two new sections were created: one dealing with the malformations of individually named vessels (previously referred to as “truncular” malformations); the second groups lesions of uncertain or debated nature (tumor versus malformation). The known genetic defects underlying vascular anomalies are included in an appendix. This classification is meant to be a framework, acknowledging that it will require modification as new scientific information becomes available.

  • Abbreviations:
    AVM —
    arteriovenous malformation
    CH —
    congenital hemangioma
    CCM —
    cerebral cavernous malformation
    CM —
    capillary malformation
    Glut-1 —
    glucose transporter 1
    IH —
    infantile hemangioma
    ISSVA —
    International Society for the Study of Vascular Anomalies
    LM —
    lymphatic malformation
    VM —
    venous malformation
    WHO —
    World Health Organization

    • Vascular anomalies (vascular tumors and vascular malformations), often named “angioma” or hemangioma, in fact represent a broad spectrum of disorders from a simple “birthmark” to life-threatening entities, which affect mainly infants, children, and young adults. Certain vascular anomalies, such as salmon patch (nevus simplex) or infantile hemangioma, are very common. Others such as port wine stain are uncommon, and still others are quite rare. Despite long-standing efforts to promulgate standard classification, nomenclature terminology of vascular anomalies continues to be confusing.1–4 The term “hemangioma” is, for example, commonly used to name different types of vascular tumors as well as vascular malformations, despite the different constitution, natural evolution, and treatment of these 2 groups of lesions. Incorrect nomenclature and misdiagnoses are commonly experienced by patients with vascular anomalies.2 Accurate diagnosis and common terminology are crucial for appropriate evaluation and management, often requiring multidisciplinary specialists.

    One of the goals of the International Society for the Study of Vascular Anomalies (ISSVA) is to achieve a uniform classification. The 1996 ISSVA classification stratified vascular anomalies into vascular malformations and proliferative vascular lesions (tumors) (Table 1).5,6 This classification was then “unofficially” updated on the basis of evolving knowledge a decade later.7 However, since then, knowledge about these disorders has increased considerably. The genetic basis of many types of vascular malformations has been elucidated and additional disease entities have been identified that need more precise classification rather than generic headings such as capillary malformation (CM), venous malformation (VM), lymphatic malformation (LM), etc, which have been used previously. The ISSVA Classification of Vascular Anomalies was recently updated by the Society’s Scientific Committee and Board to incorporate these changes and was adopted at the last workshop in Melbourne, Australia (April 2014). The goal of this article is to briefly discuss some of the present classifications and to introduce the 2014 updated ISSVA classification. The interactive document is available at www.issva.org. This classification is meant to represent the state-of-the-art in vascular anomalies classification, acknowledging that it will require modification as new scientific information becomes available.

    View this table:
    TABLE 1

    1996 ISSVA Classification Scheme

    Several classifications of vascular anomalies are available; some are general classifications, and others deal with specific organs or tissues or only with vascular tumors or vascular malformations. The earliest classification was that of Virchow, which was a pathologic classification that classified vascular anomalies as “angioma simplex, angioma cavernosum, angioma racemosum and lymphangioma.”8–10 This was a primitive classification system but appropriate for the time. The World Health Organization (WHO) classifications are generally considered as the reference classification for tumors and tumorlike diseases. The WHO classification of skin vascular “tumors”11 is a nonhierarchical list of a series of different diseases, irrespective of their tumor, malformation, reactive, or infectious nature. The WHO classification of soft tissue tumors12 uses the word “hemangioma” to describe a tumor or a malformation, further confusing the terminology.13

    These inconsistencies in classification and nomenclature make the WHO classifications misleading and confusing.8–10 It is then difficult for clinicians across specialties to communicate using a common language specific for each entity, and confusion in the naming of lesions creates inaccuracies in scientific advances and the dissemination of knowledge that may help patients. It also makes coding and statistical data about the prevalence and incidence of these lesions inaccurate.

    The 1996 ISSVA classification scheme5 is based on the fundamental separation of vascular anomalies into those lesions with a proliferative component (named “vascular tumors”) versus relatively static “vascular malformations,” following Mulliken and Glowacki's14 seminal work. Vascular malformations, which are due to inborn errors in vascular morphogenesis, are further classified on the basis of the main type of vessel they are composed of: capillary, venous, lymphatic, arterial, and combined malformations (Table 1). Another proposed classification schema, the Hamburg classification, uses vessel type as the basis of classification of vascular malformations. In each class, “truncular malformations” affecting (individual) large vessels and “extratruncular malformations” composed of smaller vessels intimately embedded in the host tissue are recognized. This distinction is clinically relevant, because “truncular” malformations seems to behave differently, and are more often associated with pulmonary embolism when affecting veins and with chylous effusion when affecting lymphatic vessels.15 However, this distinction was not considered in the 1996 ISSVA classification.

    Beginning in 2013, a group of ISSVA leaders from both the scientific committee and board, with mindful consideration given to the various existing classifications, sought to update and improve the classification of vascular anomalies, both to make it more clinically relevant and flexible and to acknowledge new knowledge including new genetic and histologic information available since its 1996 classification was approved. This updated consensus classification is intended to be applicable and functional for all medical and surgical specialties and for every organ or tissue.

    The 2014 Updated ISSVA Classification

    Because the updated classification lists a large number of different diseases, it is presented as a general table (Table 2) containing the main classes of vascular anomalies and with reference to other tables. The online version of the classification, which is available on the ISSVA Web site (www.issva.org), contains hypertext links that facilitate the navigation in the classification and its appendices.

    View this table:
    TABLE 2

    2014 ISSVA Classification of Vascular Anomalies

    Vascular Tumors

    A list of the main vascular tumors was added in the section on tumors, divided into benign, locally aggressive or borderline, and overtly malignant (Table 3). Reactive vascular proliferative lesions were grouped with benign tumors. The distinction between the reactive or tumor nature of a lesion is not always straightforward and is debated for several lesions (pyogenic granuloma/lobular capillary hemangioma,16 spindle cell hemangioma,17 epithelioid hemangioma18). Some rare vascular tumors are not included in the table and are listed as “others,” because the number of such rare lesions is rapidly increasing and because they can be found in review articles19–24 or in dermatology or soft tissue textbooks.

    View this table:
    TABLE 3

    Classification of Vascular Tumors

    Infantile hemangioma (IH; also named hemangioma of infancy) is the most common tumor of infancy with an incidence estimated between 4% and 10% of all infants and children.25,26 IHs, which are more frequent in females and in cervicofacial locations, appear within the first few weeks of life as a solitary cutaneous lesion that progressively enlarges over months and then gradually regresses25–27 (Fig 1). IHs are subclassified as focal, multifocal, segmental, and indeterminate depending on their morphology, extent, or distribution (Fig 2)28 and as superficial, deep, and mixed depending on their location in the skin and/or hypodermis. Segmental IHs may be associated with other vascular and nonvascular anomalies, especially in PHACE (posterior fossa anomaly, hemangioma, arterial anomalies, cardiovascular anomalies, eye anomalies, sternal clefting and/or supraumbilical raphe) and LUMBAR (lower body hemangioma, urogenital anomalies, ulceration, myelopathy, bony deformities, anorectal malformations, arterial anomalies, and renal anomalies) syndromes.29–31 IHs are mainly composed of proliferating endothelial cells and pericytes. These endothelial cells possess unique immunohistochemical markers (glucose transporter 1 [Glut-1], Lewis Y antigen, FCγ II receptor [FcγRII], and merosin),32,33 which are also present on placental blood endothelial cells and other blood-tissue barrier vessels (eg, brain, retina).

    FIGURE 1
    FIGURE 1

    Evolution scheme of untreated IH, RICH, and NICH. IH appears after birth, grows generally until the end of the first year of life, then stabilizes and gradually involutes most significantly during years 1 to 2 and continues to improve over the ensuing years. CHs are fully grown at birth and rapidly involute (RICH) or persist indefinitely (NICH). Reprinted with permission from Mulliken JB and Enjolras O.27 NICH, noninvoluting congenital hemangioma; RICH, rapidly involuting congenital hemangioma. The Y axis show relative size.

    FIGURE 2
    FIGURE 2

    Infantile hemangioma. A, A large segmental lesion of the face in an infant. Such lesions may be part of a PHACE syndrome. B, Involution of the lesion at age 24 months. C, Residual lesion at 10 years. D, IH endothelial cells express Glut-1, contrary to those of the normal artery (on the right side of the panel).

    Congenital hemangiomas (CHs) are less common. They are present and are fully grown at birth. They often regress rapidly,27,34 before 1 year of age, or can remain stable or partially involute (Fig 1). On the basis of this natural history, these 3 types are named, respectively, rapidly involuting CH,27,35 noninvoluting CH,27,36 and partially involuting CH37 (Figs 3 and 4). They are composed of capillary lobules where endothelial cells do not express Glut-1 and are associated with large extralobular veins, arteries, and lymphatics. Rapidly involuting CH may be associated with transient thrombocytopenia and consumption coagulopathy.38 Other clinically significant benign or locally aggressive and borderline vascular tumors are tufted angiomas and kaposiform hemangioendotheliomas.

    FIGURE 3
    FIGURE 3

    Rapidly involuting congenital hemangioma. A large bulky lesion on the scalp at birth (A) and at age 9 months (B), without treatment.

    FIGURE 4
    FIGURE 4

    Noninvoluting congenital hemangioma. A, A plaque-like round lesion of the shoulder, with coarse central telangiectasia and blue peripheral halo. B, The tumor lobules are made of vessels of various size, with a virtual or an open lumen. Some lumina are large and stellate.

    Tufted angiomas appear as erythematous or brown plaques or macules (Fig 5) in children and young adults.39 A few cases are present at birth or are associated with hyperhidrosis or hypertrichosis. Some lesions regress spontaneously, especially in congenital cases. Tufted angiomas are composed of small tufts of capillaries, characteristically surrounded by a crescentic slitlike vessel, in the dermis and subcutis, with a cannon-ball distribution. Kaposiform hemangioendothelioma may affect the skin and subcutis but often involves the deep tissues, presenting as a locally aggressive tumor (Fig 6). It histologically resembles tufted angioma with larger and confluent tumor lobules, with a more infiltrating pattern. Both lesions focally express lymphatic endothelial markers (podoplanin, Prospero homeobox 1 [Prox-1])40 but do not express Glut-1. Both tumors may be associated with the life-threatening Kasabach-Merritt phenomenon, characterized by profound thrombocytopenia and consumption of blood coagulation factors.41–43 Many authors consider tufted angioma and kaposiform hemangioendothelioma as part of a spectrum rather than distinct diseases.42 The description of the many other types of even rarer vascular tumors is beyond the focus of this article.

    FIGURE 5
    FIGURE 5

    Tufted angioma. A, Red vascular lesion with leathery quality on the arm of an infant. B, Histologically, the lesion is composed of small vascular tufts or lobules in a fibrous dermis.

    FIGURE 6
    FIGURE 6

    Kaposiform hemangioendothelioma in a child with Kasabach-Merritt phenomenon. A, Large, infiltrated, edematous and boggy lesion of the trunk, thighs, and labia major, associated with petechiae. B, Compared with tufted angioma, the lobules are larger and coalescent and infiltrate the hypodermis fat. C, a subset of tumor cells, often situated at the periphery of the lobules, express the lymphatic endothelial marker podoplanin (D2-40 antibody).

    Vascular Malformations

    Vascular malformations are divided into 4 groups: simple malformations, combined malformations, malformations of major named vessels, and malformations associated with other anomalies. “Malformations of major named vessels” was the name chosen for those malformations named “truncular” in the Hamburg classification.

    Simple Vascular Malformations

    Most simple malformations are composed mainly of only 1 type of vessel (capillaries, lymphatics, or veins), with the exception of arteriovenous malformation, which contains arteries, veins, and capillaries (ie, not a combined venous malformation with an arterial malformation but rather a separate disease composed of several types of vessels). Similarly, nonacquired arteriovenous fistula is not considered a combined malformation. For each type of simple malformation, a list of the well-defined diseases is proposed (Table 4).

    View this table:
    TABLE 4

    Simple Vascular Malformations

    Capillary malformations (CMs; Table 4) mainly affect the skin and mucosa, appearing as pink to red macules (often referred to as “port wine” stains) (Fig 7). They are present at birth and generally persist throughout life. These lesions may thicken and darken with time and may be associated with soft tissue or bone overgrowth. Some variants, which affect the midline of the head, in the forehead, eyelids, glabella, or nape (named nevus simplex or salmon patch, or so-called angel kiss or stork bite) may lighten and disappear with time, generally before 5 years of age. CMs consist of dilated capillaries and/or postcapillary venules. Lesions associated with soft tissue or bone overgrowth may contain deep lobular aggregates of venous-like vessels. CMs may be associated with other vascular and nonvascular anomalies and syndromes (see below).

    FIGURE 7
    FIGURE 7

    Capillary malformation: macular vascular lesion that blanches upon pressure.

    Lymphatic malformations (LMs; Table 4) are made up of variously dilated lymphatic channels or cysts, lined by endothelial cells with a lymphatic phenotype. They are classified as microcystic, macrocystic, and mixed subtypes. There is no uniform consensus regarding the definition of macrocystic and microcystic LMs. A useful distinction is whether the cysts can be successfully aspirated/sclerosed, resulting in a decrease in LM size,44 with the smaller cysts being more challenging. Radiographic features also can help to define the difference because macrocystic LMs are often evident as discernible fluid-filled areas. Common LM develops mainly in the cervicofacial and axillary region, generally under normal-colored skin (Fig 8), except when intralesional hemorrhage occurs. Generalized lymphatic anomaly is defined as a multifocal LM that may affect the skin and superficial soft tissue and abdominal and thoracic viscera, and often involve bone, with bone disease that is generally nonprogressive and spares the bone cortical boundaries. Chylous effusions (pericardial, pleural, or peritoneal) can be present. In contrast, Gorham-Stout disease, also named disappearing or vanishing bone disease, is characterized by LM affecting a single or multiple bones and often neighboring soft tissue, with a progressive osteolysis also affecting the cortical bone. Patients with Gorham-Stout disease can also have abdominal and thoracic visceral involvement as well as effusions. Pathologic fractures may occur in both entities. Primary lymphedemas are considered a subtype of LM due to a primary dysgenesis of the lymphatic network. The causal mutations underlying many types of primary lymphedemas are now elucidated (list available on the ISSVA Web site, www.issva.org). LMs may be associated with other vascular and nonvascular anomalies (see below).

    FIGURE 8
    FIGURE 8

    Lymphatic malformation. A, Large macrocytic LM of the axillary region. B, MRI of a macrocystic LM of the neck after contrast injection. Thin septae are visible between the large cysts. C, The endothelial cells of LM present a lymphatic phenotype (anti-podoplanin D2-40 antibody).

    Venous malformations (VMs) (Table 4) generally manifest as a blue skin discoloration when superficial (Fig 9) or as a soft subcutaneous mass and may affect every tissue or viscera. Common VMs are soft and compressible and tend to increase in volume with an increase in venous pressure (eg, Valsalva maneuver or straining) when the affected segment is dependent or with exercise. Because of sluggish flow of blood through the malformed vessels, thrombosis may occur, resulting in pain and the formation of rounded hyaline organized thrombi (phleboliths) that may be palpable or visible on imaging when calcified. Morphologically, VMs may be focal, multifocal, or diffuse, the latter typically involving an entire muscle or limb. Common VMs are generally sporadic. They may be evident at birth, but many cases, particularly those with predominantly intramuscular disease, often present later in life with pain provoked by vigorous physical activity.45 Familial VMs present generally as small multiple lesions affecting the skin and mucosa. These familial cutaneo-mucosal VMs are caused by germ-line autosomal dominant mutations in the tyrosine kinase with immunoglobulin-like and EGF-like domain 2 (Tie2) gene.46 A proportion of sporadic VMs also are caused by somatic mutations in the same Tie2 gene.47 Both common and familial VMs are composed of a network of veins with thin walls, defective in smooth muscle cell media, dissecting the host tissue. Patients affected by the blue rubber bleb syndrome (Bean syndrome) present with multiple VMs affecting the skin, soft tissue, and gastrointestinal tract, the latter responsible for chronic bleeding and anemia. Some of the skin VMs, especially on the soles and palms, present as small, round, dark hyperkeratotic bleblike or nipple-like lesions. Glomuvenous malformations, formerly known as glomangioma or glomangiomatosis, form nodular or plaque-like lesions, sometimes with a cobblestone appearance, affecting the skin (Fig 10), with rare mucosal localization. They are generally of darker blue to purple color and less compressible compared with bluish soft common VMs and are usually painful to palpation. Their histologic appearance is similar to common VMs except for the presence, at least focally, in the vein walls of rounded “glomus” cells corresponding to modified smooth muscle cells. Glomuvenous malformations are related to an inactivating mutation in the glomulin gene.48 Cerebral cavernous malformations (CCMs) are solitary or multiple nodular aggregates of thin-walled, round, closely packed veins, progressively appearing in the brain of affected patients. Contrary to other VMs, no normal tissue structures are enclosed in the lesion between the abnormal veins. CCMs are related to mutations in several different genes: KRIT1 (Krev interaction trapped 1; CCM1), malcavernin (CCM2), and PDCD10 (programmed cell death 10; CCM3).49 VMs may be associated with other vascular and nonvascular anomalies (see below).

    FIGURE 9
    FIGURE 9

    Venous malformation. A, Blue, soft, ill-defined mass involving the lips, nose, and cheek. B, MRI of the same child showing a hyperintense lobulated lesion, extending to the pharynx, on T2-weighted images. C, Histologically, VMs are made up of thin-walled stellate, generally empty vessels, dissecting the host tissue.

    FIGURE 10
    FIGURE 10

    Glomuvenous malformation. A, Multifocal dilated veins in checkerboard pattern with blue-colored skin. B, Vessel walls of glomuvenous malformation contain distinctive round or cuboidal glomus cells.

    Arteriovenous malformations (AVMs) are potentially the more aggressive type of vascular malformation. They are composed of malformed arteries, veins, and capillaries, with direct arteriovenous communications resulting in arteriovenous shunting. They may present as a pseudo-CM with pulsation at palpation or a bruit; as an enlarging red, warm, painful lesion (Fig 11); as an ulcerated and bleeding lesion due to trophic skin lesions; or rarely, with a shunt-related cardiac overload. Individual lesions may progress from a quiescent to a more aggressive lesion, following the 4 stages defined by Schobinger.50 AVMs and congenital arteriovenous fistulas may be sporadic or observed in patients presenting with hereditary hemorrhagic telangiectasia51 or CM-AVM RASA1 (RAS p21 protein activator [GTPase activating protein])–related disease.52 AVMs and arteriovenous fistulas may be associated with other vascular and nonvascular anomalies (see below).

    FIGURE 11
    FIGURE 11

    Arteriovenous malformation. A, Bright-red enlarged hand and distorted fingers in a patient with AVM of the arm treated with multiple embolizations. The patient was born with cardiomegaly, a high-flow cardiac state, and bruit in the affected arm. B, AVMs are made of round or oval thick-walled vessels of various size, evenly distributed in the tissue, along with various amounts of small capillary vessels.

    Combined Vascular Malformations

    Combined vascular malformations associate ≥2 vascular malformations in 1 lesion. These may be simple malformations, malformations of major named vessels, or a combination of both types. Some combined malformations associate a cutaneous CM and an underlying VM, LM, or AVM, or a VM with an LM. Others are also associated with nonvascular anomalies (see below). A list of the different existing combinations is presented in Table 5.

    View this table:
    TABLE 5

    Combined Vascular Malformations

    Malformations of Major Named Vessels

    These malformations affect veins, arteries, or lymphatics of generally large caliber, often axial or conducting vessels. They consist of anomalies in the origin, course, number, length, diameter (aplasia, hypoplasia, ectasia/aneurysm) or valves. Congenital arteriovenous fistulas and the persistence of embryonic vessels are also included in this group of malformations.

    Vascular Malformations Associated With Other Anomalies

    Vascular malformations (simple and/or of major named vessels) may be associated with anomalies of bone, soft tissue, or viscera. These nonvascular anomalies are often overgrowth of soft tissue and/or bone or, rarely, undergrowth. Most of these associations are eponymous syndromes. Most of these syndromes or diseases are listed in Table 6 along with their most common associations

    View this table:
    TABLE 6

    Vascular Malformations Associated With Other Anomalies

    Provisionally Unclassified Vascular Anomalies

    A small number of vascular anomalies remain unclassified, because it is still unclear whether they are tumors or malformations or because their definition and clinicopathologic characteristics are still incompletely understood. The main unclassified lesions are verrucous hemangioma and angiokeratoma,53,54 multifocal lymphangioendotheliomatosis with thrombocytopenia/cutaneovisceral angiomatosis with thrombocytopenia, kaposiform lymphangiomatosis,55,56 phosphatase and tensin homolog (PTEN) (type) hamartoma of soft tissue, and “angiomatosis” of soft tissue.57,58

    Genetic Causes of Vascular Anomalies and Other Appendices

    In recent years, our knowledge of the genetic causes of vascular anomalies has increased considerably. Many of the identified genes cause inherited diseases, but the genetic anomalies underlying some sporadic malformations with postzygotic somatic mutations have also been unraveled. Because the list of causative genetic anomalies is rapidly lengthening, it has not been included in the body of the classification but is presented in an appendix. Other appendices include a list of abbreviations used in the classification or recommended, a list of vascular anomalies possibly associated with thrombocytopenia or coagulation disorders, and some additional information on IH, the most common vascular tumor. These appendices as well as the complete classification are freely available on the ISSVA Web site (www.issva.org). It is anticipated that this comprehensive updated classification will provide a consistent framework, encourage common terminology, and aid in both management of affected patients and research.

    Acknowledgments

    ISSVA 2013 Board: Hans-Peter Berlien (President), Laurence M. Boon, Patricia Burrows, Steven Fishman, Ilona J. Frieden, and Raul Mattassi. ISSVA 2013 Scientific Committee: Francine Blei (Head), Denise Adams, Ahmad Alomari, Eulalia Baselga, Alejandro Berenstein, Maria C. Garzon, Rainer Grantzow, Juan-Carlos Lopez-Gutierrez, David J.E. Lord, Sally Mitchel, John Stuart Nelson, Julie Powell, Julie Prendiville, and Michel Wassef.

    We thank Dr John B. Mulliken for his insight and diligent review of our updated classification, as well as our colleagues, support staff, and patients who provide our inspiration.

    Footnotes

      • Accepted March 27, 2015.
    • Address correspondence to Michel Wassef, MD, Department of Pathology, Lariboisière Hospital, 2 rue Ambroise Paré, 75010 Paris, France. E-mail: michel.wassef{at}lrb.aphp.fr

    • Dr Wassef conceptualized and designed the classification and drafted the initial manuscript; Dr Blei, as chair of the scientific committee of the International Society for the Study of Vascular Anomalies, led the initiative for the updated classification and spearheaded the project and critically reviewed and revised the manuscript; Drs Adams, Baselga, Burrows, Frieden, Garzon, Lord, and Prendiville participated in the design of the classification and critically reviewed and revised the manuscript; Dr Alomari participated in the design of the classification; Drs Berenstein, Lopez-Gutierrez, and Vikkula participated in the design of the classification and critically reviewed the manuscript; Drs Mitchel and Powell critically reviewed and revised the manuscript; and all authors approved the final manuscript as submitted.

    • FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.

    • FUNDING: No external funding.

    • POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

    • COMPANION PAPER: A companion to this article can be found on page e225, online at www.pediatrics.org/cgi/doi/10.1542/peds.2015-0688.

    References

    1. ↵
      1. Hand JL,
      2. Frieden IJ
      . Vascular birthmarks of infancy: resolving nosologic confusion. Am J Med Genet. 2002;108(4):257–264pmid:11920828
      OpenUrlCrossRefPubMedWeb of Science
    2. ↵
      1. Hassanein AH,
      2. Mulliken JB,
      3. Fishman SJ,
      4. Greene AK
      . Evaluation of terminology for vascular anomalies in current literature. Plast Reconstr Surg. 2011;127(1):347–351pmid:21200229
      OpenUrlCrossRefPubMed
      1. Kollipara R,
      2. Dinneen L,
      3. Rentas KE,
      4. et al
      . Current classification and terminology of pediatric vascular anomalies. AJR Am J Roentgenol. 2013;201(5):1124–1135pmid:24147487
      OpenUrlCrossRefPubMed
    4. ↵
      1. Mulligan PR,
      2. Prajapati HJ,
      3. Martin LG,
      4. Patel TH
      . Vascular anomalies: classification, imaging characteristics and implications for interventional radiology treatment approaches. Br J Radiol. 2014;87(1035):20130392pmid:24588666
      OpenUrlCrossRefPubMed
    5. ↵
      1. Enjolras O,
      2. Mulliken JB
      . Vascular tumors and vascular malformations (new issues). Adv Dermatol. 1997;13:375–423pmid:9551150
      OpenUrlPubMed
    6. ↵
      1. Enjolras O
      . Classification and management of the various superficial vascular anomalies: hemangiomas and vascular malformations. J Dermatol. 1997;24(11):701–710pmid:9433027
      OpenUrlCrossRefPubMed
    7. ↵
      1. Enjolras O,
      2. Wassef M,
      3. Chapot R
      . Color Atlas of Vascular Tumors and Vascular Malformations. Cambridge, United Kingdom: Cambridge University Press; 2007
    8. ↵
      1. Virchow R
      . Angioma in die Krankhaften Geschwülste. Berlin, Germany: Hirshwald; 1863:306–425
      1. Wegener G
      . Ueber Lynmphangiome. Arch Klin Chir. 1877;20:641–707
      OpenUrl
    10. ↵
      1. Mulliken JB,
      2. Young AE
      . Vascular Birthmarks: Hemangiomas and Malformations. Philadelphia, PA: Saunders; 1988
    11. ↵
      1. Sangueza OP,
      2. Kasper RC,
      3. LeBoit P,
      4. et al
      . Vascular tumors. In: LeBoit PE, Burg G, Weedon D, Sarasain A, eds. Pathology and Genetics of Skin Tumors: World Health Organization Classification of Tumours. Lyon, France: IARC Press; 2006:233–246
    12. ↵
      1. Fletcher CDM,
      2. Bridge JA,
      3. Hogendoorn PCW,
      4. Mertens F
      , eds. WHO Classification of Tumors of Soft Tissue and Bone. Lyon, France: IARC Press; 2013
    13. ↵
      1. Calonje JE
      . Hemangiomas. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, eds. WHO Classification of Tumors of Soft Tissue and Bone. Lyon, France: IARC Press; 2013:138–140
    14. ↵
      1. Mulliken JB,
      2. Glowacki J
      . Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982;69(3):412–422pmid:7063565
      OpenUrlCrossRefPubMedWeb of Science
    15. ↵
      1. Lee BB,
      2. Baumgartner I,
      3. Berlien P,
      4. et al
      . Diagnosis and treatment of venous malformations consensus document of the International Union of Phlebology (IUP): updated 2013. Int Angiol. 2015;34(2):97–144
      OpenUrl
    16. ↵
      1. Godfraind C,
      2. Calicchio ML,
      3. Kozakewich H
      . Pyogenic granuloma, an impaired wound healing process, linked to vascular growth driven by FLT4 and the nitric oxide pathway. Mod Pathol. 2013;26(2):247–255
      OpenUrlCrossRefPubMed
    17. ↵
      1. Battocchio S,
      2. Facchetti F,
      3. Brisigotti M
      . Spindle cell haemangioendothelioma: further evidence against its proposed neoplastic nature. Histopathology. 1993;22(3):296–298pmid:8495966
      OpenUrlPubMed
    18. ↵
      1. Sun ZJ,
      2. Zhang L,
      3. Zhang WF,
      4. Liu B,
      5. Li ZB,
      6. Zhao YF
      . A possible hypoxia-induced endothelial proliferation in the pathogenesis of epithelioid hemangioma. Med Hypotheses. 2006;67(5):1133–1135pmid:16806726
      OpenUrlCrossRefPubMedWeb of Science
    19. ↵
      1. Requena L,
      2. Sangueza OP
      . Cutaneous vascular anomalies. Part I. Hamartomas, malformations, and dilation of preexisting vessels. J Am Acad Dermatol. 1997;37(4):523–549; quiz 549–552pmid:9344191
      OpenUrlCrossRefPubMedWeb of Science
    20. Requena L, Sangueza OP. Cutaneous vascular proliferation. Part II. Hyperplasias and benign neoplasms. J Am Acad Dermatol. 1997;37(6):887–919; quiz 920-882
    21. Requena L, Sangueza OP. Cutaneous vascular proliferations. Part III. Malignant neoplasms, other cutaneous neoplasms with significant vascular component, and disorders erroneously considered as vascular neoplasms. J Am Acad Dermatol. 1998;38(2 pt 1):143–175; quiz 176–148
    22. North PE, Waner M, Buckmiller L, James CA, Mihm MC Jr. Vascular tumors of infancy and childhood: beyond capillary hemangioma. Cardiovasc Pathol. 2006;15(6):303–317
      1. Wassef M,
      2. Hunt SJ,
      3. Santa Cruz DJ,
      4. Barnhill RL
      . Vascular tumors and vascular malformations. In: Barnhill RL, Crowson AN, Magro CM, Piepkorn MW, eds. Dermatopathology. 3rd ed. New York, NY: McGraw-Hill; 2010:802–856
    24. ↵
      1. Kozakewich HPW,
      2. Mulliken JB
      . Histopathology of vascular malformations. In: Mulliken JB, Burrows PE, Fishman SJ, eds. Mulliken & Young's Vascular Anomalies, Hemangiomas and Malformations. 2nd ed. New York, NY: Oxford University Press; 2013:480–507
    25. ↵
      1. Kilcline C,
      2. Frieden IJ
      . Infantile hemangiomas: how common are they? A systematic review of the medical literature. Pediatr Dermatol. 2008;25(2):168–173pmid:18429772
      OpenUrlCrossRefPubMedWeb of Science
    26. ↵
      1. Kanada KN,
      2. Merin MR,
      3. Munden A,
      4. Friedlander SF
      . A prospective study of cutaneous findings in newborns in the United States: correlation with race, ethnicity, and gestational status using updated classification and nomenclature. J Pediatr. 2012;161(2):240–245pmid:22497908
      OpenUrlCrossRefPubMedWeb of Science
    27. ↵
      1. Mulliken JB,
      2. Enjolras O
      . Congenital hemangiomas and infantile hemangioma: missing links. J Am Acad Dermatol. 2004;50(6):875–882pmid:15153887
      OpenUrlCrossRefPubMedWeb of Science
    28. ↵
      1. Waner M,
      2. North PE,
      3. Scherer KA,
      4. Frieden IJ,
      5. Waner A,
      6. Mihm MC Jr
      . The nonrandom distribution of facial hemangiomas. Arch Dermatol. 2003;139(7):869–875pmid:12873881
      OpenUrlCrossRefPubMedWeb of Science
    29. ↵
      1. Frieden IJ,
      2. Reese V,
      3. Cohen D
      . PHACE syndrome: the association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities. Arch Dermatol. 1996;132(3):307–311pmid:8607636
      OpenUrlCrossRefPubMedWeb of Science
      1. Metry D,
      2. Heyer G,
      3. Hess C,
      4. et al.,
      5. PHACE Syndrome Research Conference
      . Consensus statement on diagnostic criteria for PHACE syndrome. Pediatrics. 2009;124(5):1447–1456pmid:19858157
      OpenUrlAbstract/FREE Full Text
    31. ↵
      Iacobas I, Burrows PE, Frieden IJ, et al. LUMBAR: association between cutaneous infantile hemangiomas of the lower body and regional congenital anomalies. J Pediatr. 2010;157(5):795–801, e791
    32. ↵
      1. North PE,
      2. Waner M,
      3. Mizeracki A,
      4. Mihm MC Jr
      . GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol. 2000;31(1):11–22pmid:10665907
      OpenUrlCrossRefPubMedWeb of Science
    33. ↵
      1. North PE,
      2. Waner M,
      3. Mizeracki A,
      4. et al
      . A unique microvascular phenotype shared by juvenile hemangiomas and human placenta. Arch Dermatol. 2001;137(5):559–570pmid:11346333
      OpenUrlPubMedWeb of Science
    34. ↵
      1. Boon LM,
      2. Enjolras O,
      3. Mulliken JB
      . Congenital hemangioma: evidence of accelerated involution. J Pediatr. 1996;128(3):329–335pmid:8774499
      OpenUrlCrossRefPubMedWeb of Science
    35. ↵
      1. Berenguer B,
      2. Mulliken JB,
      3. Enjolras O,
      4. et al
      . Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol. 2003;6(6):495–510pmid:15018449
      OpenUrlCrossRefPubMedWeb of Science
    36. ↵
      1. Enjolras O,
      2. Mulliken JB,
      3. Boon LM,
      4. Wassef M,
      5. Kozakewich HP,
      6. Burrows PE
      . Noninvoluting congenital hemangioma: a rare cutaneous vascular anomaly. Plast Reconstr Surg. 2001;107(7):1647–1654pmid:11391180
      OpenUrlCrossRefPubMedWeb of Science
    37. ↵
      1. Nasseri E,
      2. Piram M,
      3. McCuaig CC,
      4. Kokta V,
      5. Dubois J,
      6. Powell J
      . Partially involuting congenital hemangiomas: a report of 8 cases and review of the literature. J Am Acad Dermatol. 2014;70(1):75–79pmid:24176519
      OpenUrlCrossRefPubMed
    38. ↵
      1. Baselga E,
      2. Cordisco MR,
      3. Garzon M,
      4. Lee MT,
      5. Alomar A,
      6. Blei F
      . Rapidly involuting congenital haemangioma associated with transient thrombocytopenia and coagulopathy: a case series. Br J Dermatol. 2008;158(6):1363–1370pmid:18410425
      OpenUrlCrossRefPubMed
    39. ↵
      1. Osio A,
      2. Fraitag S,
      3. Hadj-Rabia S,
      4. Bodemer C,
      5. de Prost Y,
      6. Hamel-Teillac D
      . Clinical spectrum of tufted angiomas in childhood: a report of 13 cases and a review of the literature. Arch Dermatol. 2010;146(7):758–763pmid:20644037
      OpenUrlCrossRefPubMed
    40. ↵
      1. Le Huu AR,
      2. Jokinen CH,
      3. Rubin BP,
      4. et al
      . Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma. Am J Surg Pathol. 2010;34(11):1563–1573pmid:20975337
      OpenUrlPubMed
    41. ↵
      1. Zukerberg LR,
      2. Nickoloff BJ,
      3. Weiss SW
      . Kaposiform hemangioendothelioma of infancy and childhood: an aggressive neoplasm associated with Kasabach-Merritt syndrome and lymphangiomatosis. Am J Surg Pathol. 1993;17(4):321–328pmid:8494101
      OpenUrlCrossRefPubMedWeb of Science
    42. ↵
      1. Enjolras O,
      2. Wassef M,
      3. Mazoyer E,
      4. et al
      . Infants with Kasabach-Merritt syndrome do not have “true” hemangiomas. J Pediatr. 1997;130(4):631–640pmid:9108863
      OpenUrlCrossRefPubMedWeb of Science
    43. ↵
      1. Sarkar M,
      2. Mulliken JB,
      3. Kozakewich HP,
      4. Robertson RL,
      5. Burrows PE
      . Thrombocytopenic coagulopathy (Kasabach-Merritt phenomenon) is associated with kaposiform hemangioendothelioma and not with common infantile hemangioma. Plast Reconstr Surg. 1997;100(6):1377–1386pmid:9385948
      OpenUrlCrossRefPubMedWeb of Science
    44. ↵
      1. Fishman SJ,
      2. Young AE
      . Slow-flow vascular malformations. In: Mulliken JB, Burrows PE, Fishman SJ, eds. Mulliken & Young's Vascular Anomalies, Hemangiomas and Malformations. 2nd ed. New York, NY: Oxford University Press; 2013:562–594
    45. ↵
      1. Vogel SA,
      2. Hess CP,
      3. Dowd CF,
      4. et al
      . Early versus later presentations of venous malformations: where and why? Pediatr Dermatol. 2013;30(5):534–540pmid:23679583
      OpenUrlCrossRefPubMed
    46. ↵
      1. Vikkula M,
      2. Boon LM,
      3. Carraway KL III,
      4. et al
      . Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell. 1996;87(7):1181–1190pmid:8980225
      OpenUrlCrossRefPubMedWeb of Science
    47. ↵
      Soblet J, Limaye N, Uebelhoer M, Boon LM, Vikkula M. Variable somatic TIE2 mutations in half of sporadic venous malformations. Mol Syndromol. 2013;4(4):179–183
    48. ↵
      1. Brouillard P,
      2. Boon LM,
      3. Mulliken JB,
      4. et al
      . Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations (“glomangiomas”). Am J Hum Genet. 2002;70(4):866–874pmid:11845407
      OpenUrlCrossRefPubMedWeb of Science
    49. ↵
      1. Fischer A,
      2. Zalvide J,
      3. Faurobert E,
      4. Albiges-Rizo C,
      5. Tournier-Lasserve E
      . Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis. Trends Mol Med. 2013;19(5):302–308pmid:23506982
      OpenUrlCrossRefPubMed
    50. ↵
      1. Kohout MP,
      2. Hansen M,
      3. Pribaz JJ,
      4. Mulliken JB
      . Arteriovenous malformations of the head and neck: natural history and management. Plast Reconstr Surg. 1998;102(3):643–654pmid:9727427
      OpenUrlCrossRefPubMedWeb of Science
    51. ↵
      McDonald J, Bayrak-Toydemir P, Pyeritz RE. Hereditary hemorrhagic telangiectasia: an overview of diagnosis, management, and pathogenesis. Genet Med. 2011;13(7):607–616
    52. ↵
      1. Revencu N,
      2. Boon LM,
      3. Mendola A,
      4. et al
      . RASA1 mutations and associated phenotypes in 68 families with capillary malformation-arteriovenous malformation. Hum Mutat. 2013;34(12):1632–1641pmid:24038909
      OpenUrlCrossRefPubMed
    53. ↵
      1. Tennant LB,
      2. Mulliken JB,
      3. Perez-Atayde AR,
      4. Kozakewich HP
      . Verrucous hemangioma revisited. Pediatr Dermatol. 2006;23(3):208–215pmid:16780464
      OpenUrlCrossRefPubMed
    54. ↵
      1. Mankani MH,
      2. Dufresne CR
      . Verrucous malformations: their presentation and management. Ann Plast Surg. 2000;45(1):31–36pmid:10917095
      OpenUrlCrossRefPubMed
    55. ↵
      1. North PE,
      2. Kahn T,
      3. Cordisco MR,
      4. Dadras SS,
      5. Detmar M,
      6. Frieden IJ
      . Multifocal lymphangioendotheliomatosis with thrombocytopenia: a newly recognized clinicopathological entity. Arch Dermatol. 2004;140(5):599–606pmid:15148106
      OpenUrlCrossRefPubMedWeb of Science
    56. ↵
      Prasad V, Fishman SJ, Mulliken JB, et al. Cutaneovisceral angiomatosis with thrombocytopenia. Pediatr Dev Pathol. 2005;8(4):407–419
    57. ↵
      1. Rao VK,
      2. Weiss SW
      . Angiomatosis of soft tissue: an analysis of the histologic features and clinical outcome in 51 cases. Am J Surg Pathol. 1992;16(8):764–771pmid:1497117
      OpenUrlCrossRefPubMedWeb of Science
    58. ↵
      1. Kurek KC,
      2. Howard E,
      3. Tennant LB,
      4. et al
      . PTEN hamartoma of soft tissue: a distinctive lesion in PTEN syndromes. Am J Surg Pathol. 2012;36(5):671–687pmid:22446940
      OpenUrlCrossRefPubMed
    View Abstract

     

    View this article with LENS
    Email

    Alerts
    Citation Tools
    Vascular Anomalies Classification: Recommendations From the International Society for the Study of Vascular Anomalies
    Michel Wassef, Francine Blei, Denise Adams, Ahmad Alomari, Eulalia Baselga, Alejandro Berenstein, Patricia Burrows, Ilona J. Frieden, Maria C. Garzon, Juan-Carlos Lopez-Gutierrez, David J.E. Lord, Sally Mitchel, Julie Powell, Julie Prendiville, Miikka Vikkula
    Pediatrics Jul 2015, 136 (1) e203-e214; DOI: 10.1542/peds.2014-3673
    del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
    Print
    PDF
    Insight Alerts

    Subjects

    Back to top