PURPOSE OF THE STUDY.
To determine the effect of vitamin D on atopic dermatitis (AD) severity in children with and without allergic sensitization.
Children with AD, followed in the pediatric allergy department of a Turkish tertiary care hospital, were enrolled in this study. Exclusion criteria were use of topical or systematic steroid treatment in the past month and using vitamin supplementation in the past 6 months.
Subjects were designated as having mild, moderate, or severe AD based on SCORing Atopic Dermatitis index. Skin prick testing and specific immunoglobulin E testing to foods and aeroallergens allergens were used to determine allergic sensitization. Peripheral eosinophil counts, 25-hydroxy vitamin D levels, and total immunoglobulin E were measured. Patients were grouped according to allergic sensitization.
Seventy-three pediatric AD patients, median age 33 months, were enrolled in the study; 33 of 73 were found to have allergic sensitization. Vitamin D levels of participants with moderate and severe AD were significantly lower than those with mild disease (P = .01). In the sensitized group, vitamin D levels of participants with moderate and severe disease were also significantly lower than those of participants with mild severity (P = .01). In those not sensitized, vitamin D levels did not differ among those with mild, moderate, and severe AD. There was a negative correlation between SCORing Atopic Dermatitis score and serum vitamin D level in those with allergic sensitization (P = .047, r = –0.349). There was no correlation in the group without sensitization. Vitamin D was not correlated with eosinophil count or total immunoglobulin E in either AD group.
In participants with AD and allergic sensitization, those with lower vitamin D levels had more severe AD.
This study helps set the groundwork for future studies investigating the efficacy of vitamin D supplementation in allergic individuals with moderate to severe AD.
- Copyright © 2013 by the American Academy of Pediatrics