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    Pediatrics
    September 2013, VOLUME 132 / ISSUE 3
    From the American Academy of Pediatrics
    Review Article

    Home Visiting and Outcomes of Preterm Infants: A Systematic Review

    Neera K. Goyal, Angelique Teeters, Robert T. Ammerman
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    Abstract

    BACKGROUND AND OBJECTIVES: Home visiting is 1 strategy to improve child health and parenting. Since implementation of home visiting trials 2 decades ago, US preterm births (<37 weeks) have risen by 20%. The objective of this study was to review evidence regarding home visiting and outcomes of preterm infants

    METHODS: Searches of Medline, Cumulative Index to Nursing and Allied Health Literature, Cochrane Database of Systematic Reviews, Cochrane Controlled Trial Register, PsycINFO, and Embase were conducted. Criteria for inclusion were (1) cohort or controlled trial designs; (2) home-based, preventive services for infants at medical or social risk; and (3) outcomes reported for infants born preterm or low birth weight (<2500 g). Data from eligible reports were abstracted by 2 reviewers. Random effects meta-analysis was used to synthesize data for developmental and parent interaction measures.

    RESULTS: Seventeen studies (15 controlled trials, 2 cohort studies) were reviewed. Five outcome domains were identified: infant development, parent-infant interaction, morbidity, abuse/neglect, and growth/nutrition. Six studies (n = 336) demonstrated a pooled standardized mean difference of 0.79 (95% confidence interval 0.57 to 1.02) in Home Observation for Measurement of the Environment Inventory scores at 1 year in the home-visited groups versus control. Evidence for other outcomes was limited. Methodological limitations were common.

    CONCLUSIONS: Reviewed studies suggest that home visiting for preterm infants promotes improved parent-infant interaction. Further study of interventions targeting preterm infants within existing programs may strengthen the impact and cost benefits of home visiting in at-risk populations.

    • home visiting
    • preterm infants
    • parent-child relationship
    • development
    • low birth weight
  • Abbreviations:
    Bayley MDI —
    Bayley Mental Developmental Index
    CI —
    confidence interval
    FACES —
    Family Adaptability and Cohesion Evaluation Scales
    HOME —
    Home Observation for Measurement of the Environment
    IHDP —
    Infant Health and Development Program
    LBW —
    low birth weight
    MDECAS —
    Maternal Developmental Expectations and Child-rearing Attitudes Survey
    NCAFS —
    Nursing Child Assessment Feeding Scales
    NCATS —
    Nursing Child Assessment Teaching Scales
    PPACA —
    Patient Protection and Affordable Care Act
    SMD —
    standardized mean difference
  • Currently in the United States, 12% of all infants are born preterm, or before 37 weeks of gestation.1 Compared with full-term infants (≥37 weeks), these infants are more likely to be hospitalized, to have poorer health, and to have cognitive and developmental delays in the first year of life. Preterm infants from disadvantaged backgrounds may be especially vulnerable to such outcomes because of factors such as inadequate social support, financial strain, and poorer access to health care services.2

    Home visiting is 1 strategy to improve a range of maternal-child health outcomes, including preterm birth, in high-risk populations. Currently, an estimated 400 publicly and privately funded home visiting programs provide services for at least 500 000 families in the United States,3 and an investment of federal funding in this intervention has been made through the Patient Protection and Affordable Care Act (PPACA) to expand and implement programs.4 Although some previous studies have shown promise for prenatal home visiting to improve birth weight or preterm birth,5,6 recent reviews of the published literature on this topic have demonstrated inconsistent results, likely in part because of limitations in study approaches, lack of a theoretical framework specific to pregnancy outcomes, and variation in content and delivery of interventions.7–9

    One understudied aspect of home visiting is the impact for infants born preterm who are enrolled in programs based on social risk factors either prenatally or after birth. Previous reviews suggesting that home visiting for preterm infants may improve outcomes were published ∼20 years ago.10,11 Since that time, the preterm birth rate in the United States has risen by 20%. Recent literature on the epidemiology of preterm birth has also revealed the public health impact of late preterm birth, or delivery between 34 and 36 weeks’ gestation, which affects 70% of all infants born preterm.12,13 Given the investment in home visiting through the PPACA and an increased understanding of preterm birth in recent years, an updated review of the existing literature on this topic is warranted.

    The goal of the current review was to systematically evaluate published studies of home visiting initiated in pregnancy or early infancy to promote prevention and health promotion, with a specific focus on their impact for infants born preterm. A comprehensive review of the existing evidence for this vulnerable population will be useful in understanding the complex home-visiting literature, and may help provide a target for future interventions within existing home-visiting programs. In this review we explore the following 3 questions:

    1. What is the evidence that enrollment in home visiting prenatally or in early infancy improves outcomes for preterm infants?

    2. Are there characteristics of program implementation that are associated with differences in the impact of home visiting on outcomes for preterm infants?

    3. Are there additional social risk factors (ie, maternal age or low income status) that are associated with differences in the impact of home visiting for preterm infants?

    Methods

    Study Selection

    We conducted a comprehensive literature search of studies of home-visiting programs initiated in pregnancy or early infancy, with a specific focus on studies including preterm and/or low birth weight (LBW) infants. The sample was limited to published studies of home-based, preventive, and health promotion services to families with infants at high medical or social risk for adverse child outcomes. Studies including both preterm and full-term infants were included only if intervention effects were reported separately for preterm infants. Studies of home-visiting programs involving the use of professionals, including nurses and social workers, as well as trained paraprofessionals, were included. We also included studies in which other interventions, such as center-based meetings, were provided as additional components to home visiting. Further inclusion criteria were experimental or quasi-experimental design, published in 1980 or later, conducted in the United States or Canada, home visits initiated in pregnancy or early infancy, and reported early childhood and/or parenting outcomes for infants born preterm and/or LBW. Studies that met some but not all inclusion criteria were excluded. Also excluded were single-group designs, interventions limited to a single home visit or the first week of life, and studies of children primarily with chronic conditions other than prematurity or LBW.

    Data Sources

    A comprehensive literature search was undertaken to identify literature from January 1980 through November 2012. The search strategy involved searching electronic databases, inspecting bibliographies of retrieved articles, and hand-searching the published literature. We searched the Medline, Cumulative Index to Nursing and Allied Health Literature, Cochrane Database of Systematic Reviews and Cochrane Controlled Trial Register, and PsycINFO databases. Additionally, Embase was searched via SciVerse Scopus.

    The search was undertaken by using the following search terms: home visiting, home visitation, early intervention, at-risk, infant, neonate, neonatal, low birth weight, preterm, premature. Reference lists of published review articles and meta-analyses were used to identify additional studies. Care was taken not to overrepresent a single study associated with multiple published reports. We abstracted data from across multiple published reports, thus yielding the most complete description possible of that particular study.

    Data Collection and Analysis

    All potential reports were reviewed and data from eligible reports were abstracted separately by 2 reviewers. Discrepancies were resolved by consensus. Study quality was assessed using the Consolidated Standards of Reporting Trials guidelines for the controlled trials, and the Strengthening the Reporting of Observational studies in Epidemiology guidelines for the cohort studies. Both sets of guidelines are made up of checklists against which the quality of studies should be assessed.

    Because the studies covered a wide range of outcomes and it was not possible to combine results into 1 summary statistic, a primarily narrative analysis of the data was conducted. However, random effects meta-analysis was used to synthesize data for separate outcome domains on clinical determination of sufficient similarity between subjects and outcomes of included studies.14 Statistical heterogeneity was determined using I2 tests. A standardized mean difference was calculated for continuous data measures. All data analyses were performed with a random-effects model using Comprehensive Meta-Analysis, Version 2 (Biostat Inc, Englewood, NJ).

    Results

    The search yielded 38 eligible publications, representing 17 individual studies evaluating a program of home visiting (see Fig 1). An additional 83 study reports were considered and excluded based on sampling criteria. The total of all samples in the included studies was 2983 infants, with a range of 45 to 985 and a median sample size of 100.

    FIGURE 1
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    FIGURE 1

    Flow diagram showing selection of articles.

    Program Descriptions

    Table 1 describes each program with respect to targeted infant population, models of service delivery (when commenced and at what age concluded, number and length of home visits), home visitor background, and any additional program components.

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    TABLE 1

    Characteristics of Included Home-Visiting Programs

    Infant Population

    All of the included programs enrolled infants either during birth hospitalization or soon after discharge. None of the studies meeting eligibility criteria for this review included participants enrolled prenatally in home visiting. Although 13 programs used specific enrollment criteria based either on gestational age, birth weight, or both, 4 programs instead targeted a more general population of infants requiring care in the NICU, most of whom were preterm and/or LBW.

    Although most programs defined preterm as <37 weeks’ gestation, there was some variability; 2 programs defined preterm as <36 weeks’ gestation, 1 defined preterm as <35 weeks’ gestation, and 1 program included only infants at <34 weeks’ gestation. As seen in Table 1, 6 programs identified their study population primarily by birth weight instead of gestational age, with cutoff values for inclusion ranging from 1500 g to 2000 g. The targeted preterm infant populations varied in terms of severity of prematurity and LBW status, resulting in ranges in mean gestational age of 30 to 35 weeks, and mean birth weight of 1200 to 2400 g, across studies.

    Intervention Details

    Programs varied with respect to home visitor training background. Eight of the 17 programs used nurses, 3 used development specialists, 3 used trained paraprofessionals or graduate students, 2 used a mix of provider types, and 1 did not specify. Duration of home visiting ranged from 8 weeks to 3 years. As seen in Table 1, visit frequency also varied; whereas many programs provided visits weekly or biweekly early in infancy, some studies reported lower visit frequencies; for example, Brooten and colleagues, who reported visits through the first week home, then at 1, 9, 12, and 18 months.15,16 Seven studies implemented an additional intervention component during birth hospitalization, before the discharge home, focusing on parenting or infant development. In 2 programs, the Infant Health and Development Program (IHDP)17–24 and the Mother Infant Communication Project,25,26 the intervention also included attendance at center-based groups.

    Reported Outcomes

    We identified 5 general domains of outcomes: infant development, morbidity and health care utilization, abuse and neglect, parent-infant interaction, and growth and nutrition (see Table 2). Most reviewed studies, 13 of 17, assessed outcomes in more than 1 domain. The most common outcomes reported were in the domains of infant development (13 studies) and parent-infant interaction (14 studies). Child abuse/neglect was the least-reported outcome domain, with only 2 reviewed studies providing data.

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    TABLE 2

    Summary of Outcome Domains for Included Studies

    Infant Development

    The 13 studies assessing infant development provide a wide range of effect sizes and study follow-up periods. Although most studies observed a significant difference between intervention and control groups on at least 1 developmental outcome measure, 3 studies (Brooten and colleagues,15,16 Casiro et al,27 and Zahr28) observed no significant differences at any of the assessment periods (18 months, 12 months, and throughout 24 months, respectively).

    As shown in Table 2, multiple studies assessed infant development using the Bayley Mental Developmental Index (Bayley MDI). We therefore conducted a meta-analysis of effect sizes for Bayley MDI scores using studies with infant assessment data at or near 1 year of age. Although a total of 11 studies provided Bayley MDI data, 2 studies, Teti et al29 and Brooten and colleagues,15,16 were empirically omitted from the meta-analysis because of disparate follow-up ages (3–4 months and 18 months, respectively). The remaining 9 pooled studies27,28,30–44 (n = 516) demonstrate a statistically significant overall effect on the standardized mean difference (SMD) in Bayley MDI scores in the home-visited group versus the control group, with a pooled SMD of 0.50 (95% confidence interval [CI], 0.18 to 0.83) (Fig 2, Panel A). However, significant statistical heterogeneity was noted between the studies (I2 = 67.8%, P = .002). On further review of potential causes for study heterogeneity, we observed that when the 5 programs reporting weekly or biweekly initial visits were analyzed separately,30–33,35,37–39,41,42 the pooled SMD was 0.90 (95% CI 0.60 to 1.19) and there was no longer significant statistical heterogeneity (I2 = 8.8%, P = .36). In contrast, the remaining 4 programs with initial visit frequency that was not well defined or less than biweekly27,28,34,36,40,43,44 had a pooled SMD of 0.12 (95% CI –0.12 to 0.35) when analyzed separately, again with no statistical heterogeneity (I2 = 0.0%, P = .66).

    FIGURE 2
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    FIGURE 2

    Meta-analysis of effects of home-visiting intervention on Bayley MDI scores and HOME Inventory scores at ∼1 year of age. A, Pooled effect on Bayley MDI scores. B, Pooled effect on HOME Inventory scores.

    Parent-Infant Interaction

    Outcomes in the domain of parent-infant interaction were reported in 14 of the 17 included studies. Of these, only 1 demonstrated an absence of positive intervention effect on any parent-infant interaction measures.28 As shown in Table 2, a range of these measures was used to assess parent-infant interaction across studies, including such diverse tools as the Maternal Developmental Expectations and Child-rearing Attitudes Survey (MDECAS), the Nursing Child Assessment Feeding Scales and Nursing Child Assessment Teaching Scales (NCAFS and NCATS), and the Family Adaptability and Cohesion Evaluation Scales (FACES).

    Because 8 studies provided either a total score or subscale score for the Home Observation for Measurement of the Environment (HOME) Inventory, we conducted a meta-analysis of effect sizes for HOME Inventory scores using studies with data at or near 1 year of age. Of these, 2 studies, Affleck et al45 and Zahr28 were empirically omitted from the meta-analysis because of disparate follow-up ages (6 months and 18 months, respectively).The remaining 6 pooled studies25–27,30,38,39,41,42,46,47 (n = 336) demonstrate a statistically significant overall effect on the HOME Inventory scores in the home-visited group versus the control group, with a pooled SMD of 0.79 (95% CI 0.57–1.02) (Fig 2, Panel B). Given the lack of significant statistical heterogeneity between studies (I2 = 0.0%, P = .77), we also repeated this analysis using a fixed effects model, and results were identical.

    Morbidity and Health Service Utilization

    Four studies assessed the effect of home visiting on a range of morbidity and health service utilization outcomes. Finello et al46,47 found a significant decrease in the incidence of hospitalization among intervention infants at 6 months but not 12 months. Results of the IHDP demonstrated a small, statistically significant increase in maternally reported minor illnesses at 3 years of age, but only for infants weighing <1500 g, and no effect on serious health conditions.17–24 Neither Casiro et al nor Brooten and colleagues demonstrated significant intervention effects on rates of hospitalization or acute care visits.15,16,27

    Nutrition and Growth

    Five studies used anthropometric measures to assess physical growth, with follow-up periods ranging from 3 months to 8 years across studies. Only Field et al38,39 demonstrated a significant intervention effect on weight and length during infancy (at 4 and 12 months). Data from the IHDP at 8 years did demonstrate that intervention infants had higher weights, heights, and head circumferences compared with control infants, but only among those weighing <1500 g at birth.19

    Child Abuse/Neglect

    Brooten and colleagues15,16 and Finello et al46,47 measured the incidence of reported child abuse among study infants; neither observed a significant difference between intervention and control groups.

    Program Design and Theory of Change

    Program Intensity

    As shown in Table 3, most studies did not provide information on whether participants received the full prescribed number of home visits. Only 1 study (Zahr28) evaluated a dosage effect of the intervention on observed outcomes (based on duration on home visiting received by the intervention group); no outcome difference was detected between 2 intervention arms with differing durations, 4 months and 12 months. Among 10 studies that demonstrated a significant intervention effect on developmental outcomes, duration of home visiting ranged from 3 months to 3 years. The Mother-Infant Transaction Program study in particular demonstrated sustained differences in developmental outcomes after 3 years, despite a home-visiting intervention limited to 4 visits over the first 90 days after NICU discharge.34,36,43,44 Of note, however, the Mother-Infant Transaction Program also used a hospital-based component for intervention infants and their families during NICU hospitalization.

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    TABLE 3

    Methodologic Descriptions of Included Studies

    Additional Population Targets

    Six studies25,26,28–30,38–40 targeted families of preterm infants with additional demographic characteristics, such as race or socioeconomic status. The study by Field et al38,39 was the only one included in this review to focus specifically on teenage mothers of preterm infants, reporting significant intervention effects in the outcome domains of infant development, parent-infant interactions, and nutrition and growth. Although the IHDP did not specifically target subpopulations of infants based on demographic characteristics, results of their analysis did demonstrate a significant interaction effect of maternal education, such that only the intervention subgroup with a high school education or less showed significant developmental differences at 2 and 3 years of age.17–24

    Three studies described a significant interaction effect between birth weight and the home-visiting intervention, although the direction of this influence was not consistent between studies. Teti et al29 observed a significant difference between intervention and control groups when assessed at 3 to 4 months of age, but only among infants weighing <1000 g. Barrera et al41,42 also described significant differences in developmental outcomes at 4.5 years for infants weighing <1500 g but not for heavier infants. These results contrast with findings from the IHDP, in which significant cognitive differences were observed at 5 and 8 years of life among infants 1500 to 2500 g but not those weighing <1500 g at birth.17–24

    Theory of Change

    As seen in Table 1, 8 of the 13 studies measuring developmental outcomes described an explicit theory of change to support program development and key hypotheses, most of which demonstrated a significant intervention effect on at least 1 developmental outcome measure. Most commonly, studies cited a “transactional model,” focusing on the interaction between infants and parents as the primary target of intervention.

    Study Quality

    As seen in Table 3, 3 studies used nonrandom comparison groups; the remainder were randomized controlled trials. Most included studies compared an intervention including home visiting with a control population receiving no home visiting. However, control groups in 3 studies also received home visiting, whereas the intervention groups were given an enhanced or modified model of home visiting. Five of the 17 studies provided a calculation of statistical power, and 12 studies reported blinding observers to treatment group. Most studies demonstrated no significant differences in maternal or infant characteristics at baseline.

    Overall, loss to follow-up was the weakest aspect of most studies, particularly those using a longer follow-up period, as this reduced sample size available for assessment of outcomes. Four studies did not report effect of group assignment on attrition, whereas 9 studies reported similar or equal loss to follow-up between groups, and 4 studies reported differential loss to follow-up based on group assignment.

    Discussion

    We identified 17 individual studies published in the literature since 1980 that evaluate the effectiveness of home visiting for preterm infants and their parents. As with much of the literature on home visiting, the reviewed studies vary in terms of design and implementation of the intervention, outcomes evaluated, and specific study population. Our pooled analysis of HOME Inventory scores supports a positive effect of home visiting on parenting outcomes for infants born preterm and/or LBW. Pooled analysis of Bayley MDI scores at 1 year demonstrates a statistically significant overall effect but with heterogeneity between programs potentially related to visit frequency. We found limited studies to support whether home visiting among this population reduces hospitalization or morbidity. We also found limited studies to support whether home visiting among preterm and/or LBW infants improves physical growth in infancy.

    Only 2 reviewed studies measured child abuse as an outcome, and results are not sufficient to either support or refute the effect of home visiting in a preterm population. However, additional work by Bugental and Schwartz,48 not included in this review because of inclusion of a more heterogeneous, older infant sample, demonstrates the benefits of a home-visiting curriculum tailored to medically at-risk infants to prevent harsh parenting tactics. Further intervention research targeting a more specific population of preterm infants may be important, particularly given what is known about their increased risk of child abuse and neglect.49

    Several reviewed studies used a well-defined theory of change to guide program implementation and demonstrated a positive intervention effect on developmental outcomes. Additionally, results of several studies suggested that additional characteristics, including birth weight and social risk factors, may moderate the impact of home visiting on developmental outcomes. This is consistent with recent literature on home visiting promoting the importance of aligning theory, implementation, target population, and outcomes.50 One notable exception to this pattern is the study by Zahr,28 which describes a population of low-income Hispanic families and their LBW infants. Despite a well-defined conceptual model and targeted population, no measurable intervention effects were observed. Although the lack of significantly positive findings may have resulted from methodological limitations, including a high sample attrition rate, the authors suggest that specific cultural factors may have contributed to a lack of alignment between program objectives and actual needs of the population.

    Gaps in the Literature

    Each of the reviewed studies enrolled infants and their parents into a program of home visiting after preterm delivery, either during or after discharge from the birth hospital. We were unable to find examples of home-visiting programs that enrolled families prenatally on the basis of social risk factors and reported specific outcome data for infants born preterm who continue to receive prevention services through the program. Further research would be useful in understanding the utility of a tailored curriculum for preterm infants within a larger program serving socially disadvantaged populations. Qualitative research may make an important contribution to this process by obtaining parents’ and home visitors’ views regarding the factors considered to be most important for the health and well-being of enrolled preterm infants.

    Although previous studies of home visiting suggest that intensity of the intervention may be an important influence on program effectiveness,11,51 a subanalysis of data from the IHDP indicates that passive exposure to the intervention (ie, number of home visits) may not be as important as level of parental engagement.22 The current review demonstrates substantial heterogeneity in program implementation across studies as well as inclusion of non–home-based curriculum components. Future research in this area may focus on the effect of program intensity on outcomes for preterm infants enrolled in home visiting, with the goal of identifying a minimum duration and visit frequency to achieve improvements.

    Finally, an important gap in interpretation of the current literature is the differential effect of home visiting on infants based on gestational age. Although 3 studies examine an interaction effect of birth weight for this intervention, stratification by birth weight alone may not sufficiently distinguish infants in terms of their true risk for complications.52 In light of the recent literature on neurodevelopmental and medical outcomes of late preterm infants, many of whom would not be classified as LBW, further research should focus on the effects of home visiting stratified by discrete gestational age ranges.

    Strengths and Limitations of the Review

    This is a comprehensive synthesis of recent evidence regarding the impact of home visiting on outcomes for preterm and LBW infants. Our review includes prospective studies only, thereby avoiding problems of reverse causality inherent in cross-sectional and case-control designs. Most studies included objective outcome measures assessed by examiners blinded to group status, minimizing the potential for reporting bias. In addition to assessing the methodological quality of included studies, our review evaluates the strength of program logic in relationship to its underpinning theory, which has been recently emphasized in the home-visiting literature. Last, our use of 2 independent reviewers to extract data is a strength of this review.

    Although several included studies were well-designed and of sufficient size to detect clinically important intervention effects, many were of limited size, with attrition rates of a third or more contributing to findings that may have been biased. Additionally, because only published studies were included, this review may be subject to error because of publication bias. However, when the 9 studies contributing 1-year Bayley MDI score data were investigated with a funnel plot of SE, results did not appear to scatter asymmetrically (data not shown).

    Conclusions

    Many studies support that home visits in early infancy for preterm infants promote improved parent-infant interaction and infant development. The evidence regarding other infant outcomes, including morbidity, growth and nutrition, and child abuse or neglect, is more limited. Although few studies have evaluated the effectiveness of home visiting for preterm infants with additional social risk factors, the available literature suggests that targeted subgroups may confer benefit from these programs. Further studies are needed to examine the role of home visiting for preterm infants from socially disadvantaged backgrounds, including those who are enrolled in home visiting prenatally. Further evaluation of targeted interventions for this subgroup within larger home-visiting programs may strengthen their impact on health of high-risk communities and enhance the costs-benefits of home visiting, which has received a large public investment through the PPACA.

    Acknowledgments

    The authors thank Dr Rita Pickler for critical review of the manuscript and Dr Jareen Meinzen-Derr for biostatistical consultation.

    Footnotes

      • Accepted June 19, 2013.
    • Address correspondence to Neera Goyal, MD, MSc, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, 3333 Burnet Ave, ML# 7009, Cincinnati, OH 45229. E-mail: neera.goyal{at}cchmc.org
    • Dr Goyal conceptualized and designed the study, reviewed all included studies, and drafted the initial manuscript; Dr Teeters assisted with review of included studies and critically reviewed the manuscript; Dr Ammerman supervised conceptualization and design of the study, assisted with review of included studies, and reviewed and revised the manuscript; and all authors approved the final manuscript as submitted.

    • The content is solely the responsibility of the authors and does not necessarily represent the official views of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institute of Mental Health, or the National Institutes of Health.

    • FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.

    • FUNDING: Dr Goyal’s involvement in this project was supported by the Building Interdisciplinary Research Careers in Women’s Health program, cofunded by the Office of Research on Women’s Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, award 5K12HD051953-07. Dr Ammerman was supported by grant R01MH087499 from the National Institute of Mental Health. Funded by the National Institutes of Health (NIH).

    • POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

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    Home Visiting and Outcomes of Preterm Infants: A Systematic Review
    Neera K. Goyal, Angelique Teeters, Robert T. Ammerman
    Pediatrics Sep 2013, 132 (3) 502-516; DOI: 10.1542/peds.2013-0077

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    Home Visiting and Outcomes of Preterm Infants: A Systematic Review
    Neera K. Goyal, Angelique Teeters, Robert T. Ammerman
    Pediatrics Sep 2013, 132 (3) 502-516; DOI: 10.1542/peds.2013-0077
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