SIDS and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment
- Task Force on Sudden Infant Death Syndrome
Despite a major decrease in the incidence of sudden infant death syndrome (SIDS) since the American Academy of Pediatrics (AAP) released its recommendation in 1992 that infants be placed for sleep in a nonprone position, this decline has plateaued in recent years. Concurrently, other causes of sudden unexpected infant death occurring during sleep (sleep-related deaths), including suffocation, asphyxia, and entrapment, and ill-defined or unspecified causes of death have increased in incidence, particularly since the AAP published its last statement on SIDS in 2005. It has become increasingly important to address these other causes of sleep-related infant death. Many of the modifiable and nonmodifiable risk factors for SIDS and suffocation are strikingly similar. The AAP, therefore, is expanding its recommendations from being only SIDS-focused to focusing on a safe sleep environment that can reduce the risk of all sleep-related infant deaths including SIDS. The recommendations described in this report include supine positioning, use of a firm sleep surface, breastfeeding, room-sharing without bed-sharing, routine immunization, consideration of a pacifier, and avoidance of soft bedding, overheating, and exposure to tobacco smoke, alcohol, and illicit drugs. The rationale for these recommendations is discussed in detail in this technical report. The recommendations are published in the accompanying “Policy Statement—Sudden Infant Death Syndrome and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment,” which is included in this issue (www.pediatrics.org/cgi/doi/10.1542/peds.2011-2220).
- sudden infant death
- infant mortality
- sleep position
- sleep surface
Literature searches using PubMed were conducted for each of the topics in this technical report and concentrated on articles published since 2005 (when the last policy statement1 was published). In addition, to provide additional information regarding sleep-environment hazards, a white paper was solicited from the US Consumer Product Safety Commission (CPSC).2 Strength of evidence for recommendations3 was determined by the task force members. Draft versions of the policy statement4 and technical report were submitted to relevant committees and sections of the American Academy of Pediatrics (AAP) for review and comment. After the appropriate revisions were made, a final version was submitted to the AAP Executive Committee and Board of Directors for final approval.
SUDDEN INFANT DEATH SYNDROME AND SUDDEN UNEXPECTED INFANT DEATH: DEFINITIONS AND DIAGNOSTIC ISSUES
Sudden Infant Death Syndrome and Sudden Unexpected Infant Death
Sudden infant death syndrome (SIDS) is a cause assigned to infant deaths that cannot be explained after a thorough case investigation that includes a scene investigation, autopsy, and review of the clinical history.5 Sudden unexpected infant death (SUID), also known as sudden unexpected death in infancy (SUDI), is a term used to describe any sudden and unexpected death, whether explained or unexplained (including SIDS), that occurs during infancy. After case investigation, SUIDs can be attributed to suffocation, asphyxia, entrapment, infection, ingestions, metabolic diseases, and trauma (accidental or nonaccidental). The distinction between SIDS and other SUIDs, particularly those that occur during an observed or unobserved sleep period (sleep-related infant deaths), such as accidental suffocation, is challenging and cannot usually be determined by autopsy alone. Scene investigation and review of the clinical history are also required. A few deaths that are diagnosed as SIDS are found, after further specialized investigations, to be attributable to metabolic disorders or arrhythmia-associated cardiac channelopathies.
Although standardized guidelines for conducting thorough case investigations have been developed,6 these guidelines have not been uniformly adopted across the more than 2000 US medical examiner and coroner jurisdictions.7 Information from emergency responders, scene investigators, and caregiver interviews can provide additional evidence to assist death certifiers (ie, medical examiners and coroners) in accurately determining the cause of death. However, death certifiers represent a diverse group with varying levels of skills and education as well as diagnostic preferences. Recently, much attention has been focused on reporting differences among death certifiers. At one extreme, some certifiers have abandoned using SIDS as a cause-of-death explanation.7 At the other extreme, some certifiers will not classify a death as suffocation in the absence of a pathologic marker of asphyxia at autopsy (ie, pathologic findings diagnostic of oronasal occlusion or chest compression8), even with strong evidence from the scene investigation that suggests a probable accidental suffocation.
US Trends in SIDS, Other SUIDs, and Postneonatal Mortality
To monitor trends in SIDS and other SUIDs nationally, the United States classifies diseases and injuries according to the International Classification of Diseases (ICD) diagnostic codes. This classification system is designed to promote national and international comparability in the assignment of cause-of-death determinations; however, this system might not provide the optimal precision in classification desired by clinicians and researchers. In the United States, the National Center for Health Statistics assigns a SIDS diagnostic code (ICD-10 R95) if the death is classified with terminology such as SIDS (including presumed, probable, or consistent with SIDS), sudden infant death, sudden unexplained death in infancy, sudden unexpected death in infancy, or sudden unexplained infant death on the certified death certificate. A death will be coded as “other ill-defined and unspecified causes of mortality” (ICD-10 R99) if the cause of the death is reported as unknown or unspecified. A death is coded as “accidental suffocation and strangulation in bed” (ASSB) (ICD-10 W75) when the terms “asphyxia,” “asphyxiated,” “asphyxiation,” “strangled,” “strangulated,” “strangulation,” “suffocated,” or “suffocation” are reported, along with the terms “bed” or “crib.” This code also includes deaths while sleeping on couches and armchairs.
Although SIDS was defined somewhat loosely until the mid-1980s, there was minimal change in the incidence of SIDS in the United States until the early 1990s. In 1992, in response to epidemiologic reports from Europe and Australia, the AAP recommended that infants be placed for sleep in a nonprone position as a strategy for reducing the risk of SIDS.9 The “Back to Sleep” campaign was initiated in 1994 under the leadership of the National Institute of Child Health and Human Development as a joint effort of the Maternal and Child Health Bureau of the Health Resources and Services Administration, the AAP, the SIDS Alliance (now First Candle), and the Association of SIDS and Infant Mortality Programs.10 The Eunice Kennedy Shriver National Institute of Child Health and Human Development began conducting national surveys of infant care practices to evaluate the implementation of the AAP recommendation. Between 1992 and 2001, the SIDS rate declined, and the most dramatic declines occurred in the years immediately after the first nonprone recommendations, consistent with the steady increase in the prevalence of supine sleeping (Fig 1).11 The US SIDS rate declined from 120 deaths per 100 000 live births in 1992 to 56 deaths per 100 000 live births in 2001, representing a decrease of 53% over 10 years. However, from 2001 to 2006 (the latest year from which data are available), the rate has remained constant (Fig 1). In 2006, 2327 infants died from SIDS. Although SIDS rates have declined by more than 50% since the early 1990s, SIDS remains the third-leading cause of infant mortality and the leading cause of postneonatal mortality (28 days to 1 year of age).
The all-cause postneonatal death rate has followed a trend similar to the SIDS rate: there was a 29% decline from 1992 to 2001 (from 314 to 231 per 100 000 live births). From 2001 until 2006, postneonatal mortality rates have also remained fairly unchanged (from 231 to 224 per 100 000 live births); the average decline is 3%.12
Several recent studies have revealed that some deaths previously classified as SIDS are now being classified as other causes of infant death (eg, accidental suffocation and other ill-defined or unspecified causes).13,14 Since 1999, much of the decline in SIDS rates might be explained by increasing rates of these other causes of SUID, particularly over the years 1999–2001.13,15 A notable change is in deaths attributable to ASSB. Between 1984 and 2004, ASSB infant mortality rates more than quadrupled, from 2.8 to 12.5 deaths per 100 000 live births,15 which represents 513 infant deaths attributed to ASSB in 2004 compared with 103 in 1984.
The apparent leveling of the previously declining SIDS rate is occurring coincident with a slowing in the reduction of the prevalence of prone positioning. The prevalence of supine sleep positioning, as assessed from an ongoing national sampling, increased from 13% in 1992 to 72% in 2001. From 2001 until 2010, the prevalence of supine sleep positioning has been fairly stagnant (prevalence in 2010: 75%).11
The 1998 and 2005 AAP policy statements and the Back to Sleep campaign not only addressed the importance of back sleeping but also provided recommendations for other infant care practices that may reduce the risk of SIDS and other sleep-related infant deaths.1,9 Unfortunately, the ability to measure the prevalence of these other risk factors is limited by lack of data. Death certificates are useful for monitoring trends in SIDS mortality, but the circumstances and events that lead to death are not captured in vital statistics data.16 The Centers for Disease Control and Prevention recently began to pilot a SUID case registry that will provide supplemental surveillance information about the sleep environment at the time of death, infant health history, and the comprehensiveness of the death scene investigation and autopsy. These factors will better describe the circumstances surrounding SIDS and other sleep-related infant deaths and assist researchers in determining the similarities and differences between these deaths.
Racial and Ethnic Disparities
SIDS mortality rates, similar to other causes of infant mortality, have notable racial and ethnic disparities (Fig 2).17 Despite the decline in SIDS in all races and ethnicities, the rate of SIDS in non-Hispanic black (99 per 100 000 live births) and American Indian/Alaska Native (112 per 100 000 live births) infants was double that of non-Hispanic white infants (55 per 100 000 live births) in 2005 (Fig 2). SIDS rates for Asian/Pacific Islander and Hispanic infants were nearly half the rate for non-Hispanic white infants. Furthermore, similar racial and ethnic disparities have been seen with deaths attributed to both ASSB (Fig 3) and ill-defined or unspecified deaths (Fig 4). Differences in the prevalence of supine positioning and other sleep-environment conditions among racial and ethnic populations might contribute to these disparities.17 The prevalence of supine positioning in 2010 among white infants was 75%, compared with 53% among black infants (Fig 5). The prevalence of supine sleep positioning among Hispanic and Asian infants was 73% and 80%, respectively.11 Parent-infant bed-sharing18,–,20 and use of soft bedding are also more common among black families than among other racial/ethnic groups.21,22 Additional work in promoting appropriate infant sleep position and sleep-environment conditions is necessary to resume the previous rate of decline (observed during the 1990s) for SIDS and all-cause postneonatal mortality.
Age at Death
Ninety percent of SIDS cases occur before an infant reaches the age of 6 months. The rate of SIDS peaks between 1 and 4 months of age. Although SIDS was once considered a rare event during the first month of life, in 2004–2006, nearly 10% of cases coded as SIDS occurred during the first month. SIDS is uncommon after 8 months of age (Fig 6).14 A similar age distribution is seen for ASSB (Fig 7).
Seasonality of SIDS
A pattern in seasonality of SIDS is no longer apparent. SIDS deaths have historically been observed more frequently in the colder months, and the fewest SIDS deaths occurred in the warmest months.23 In 1992, SIDS rates had an average seasonal change of 16.3%, compared with only 7.6% in 1999,24 which is consistent with reports from other countries.25
PATHOPHYSIOLOGY AND GENETICS OF SIDS
A working model of SIDS pathogenesis includes a convergence of exogenous triggers or “stressors” (eg, prone sleep position, overbundling, airway obstruction), a critical period of development, and dysfunctional and/or immature cardiorespiratory and/or arousal systems (intrinsic vulnerability) that lead to a failure of protective responses (see Fig 8).26 Convergence of these factors ultimately results in a combination of progressive asphyxia, bradycardia, hypotension, metabolic acidosis, and ineffectual gasping, leading to death.27 The mechanisms responsible for dysfunctional cardiorespiratory and/or arousal protective responses remain unclear but might be the result of in utero environmental conditions and/or genetically determined maldevelopment or delay in maturation. Infants who die from SIDS are more likely to be born at low birth weight or growth restricted, which suggests an adverse intrauterine environment. Other adverse in utero environmental conditions include exposure to nicotine or other components of cigarette smoke and alcohol.
Recent studies have explored how prenatal exposure to cigarette smoke may result in an increased risk of SIDS. In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function,28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration),29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants,32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater-than-expected increase in blood pressure and heart rate in response to breathing 4% carbon dioxide or a 60° head-up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.
Brainstem abnormalities that involve the medullary serotonergic (5-hydroxytryptamine [5-HT]) system in up to 70% of infants who die from SIDS are the most robust and specific neuropathologic findings associated with SIDS and have been confirmed in several independent data sets and laboratories.37,–,40 This area of the brainstem plays a key role in coordinating many respiratory, arousal, and autonomic functions and, when dysfunctional, might prevent normal protective responses to stressors that commonly occur during sleep. Since the Task Force on Sudden Infant Death Syndrome report in 2005, more specific abnormalities have been described, including decreased 5-HT1A receptor binding, a relative decrease in binding to the serotonin transporter, and increased numbers of immature 5-HT neurons in regions of the brainstem that are important for autonomic function.41 These findings are not confined to nuclei containing 5-HT neurons but also include relevant projection sites. The most recent study report described in these same regions decreased tissue levels of 5-HT and tryptophan hydroxylase, the synthesizing enzyme for serotonin, and no evidence of excessive serotonin degradation as assessed by levels of 5-hydroxyindoleacetic acid (the main metabolite of serotonin) or ratios of 5-hydroxyindoleacetic acid to serotonin.30 A recent article described a significant association between a decrease in medullary 5-HT1A receptor immunoreactivity and specific SIDS risk factors, including tobacco smoking.40 These data confirm results from earlier studies in humans39,41 and are also consistent with studies in piglets that revealed that postnatal exposure to nicotine decreases medullary 5-HT1A receptor immunoreactivity.42 Animal studies have revealed that serotonergic neurons located in the medullary raphe and adjacent paragigantocellularis lateralis play important roles in many autonomic functions including the control of respiration, blood pressure, heart rate, thermoregulation, sleep and arousal, and upper airway patency. Engineered mice with decreased numbers of 5-HT neurons and rats or piglets with decreased activity secondary to 5-HT1A autoreceptor stimulation have diminished ventilator responses to carbon dioxide, dysfunctional heat production and heat-loss mechanisms, and altered sleep architecture.43 These studies linked SIDS risk factors with possible pathophysiology.
There is no evidence of a strong heritable contribution for SIDS. However, genetic alterations have been observed that may increase the vulnerability to SIDS. Genetic variation can take the form of common base changes (polymorphisms) that alter gene function or rare base changes (mutations) that often have highly deleterious effects. Several categories of physiologic functions relevant to SIDS have been examined for altered genetic makeup. Genes related to the serotonin transporter, cardiac channelopathies, and the development of the autonomic nervous system are the subject of current investigation.44 The serotonin transporter recovers serotonin from the extracellular space and largely serves to regulate overall serotonin neuronal activity. Results of a recent study support those in previous reports that polymorphisms in the promoter region that enhance the efficacy of the transporter (L) allele seem to be more prevalent in infants who die from SIDS compared with those reducing efficacy (S)45; however, at least 1 study did not confirm this association.46 It has also been reported that a polymorphism (12-repeat intron 2) of the promoter region of the serotonin transporter, which also enhances serotonin transporter efficiency, was increased in black infants who died from SIDS44 but not in a Norwegian population.45
It has been estimated that 5% to 10% of infants who die from SIDS have novel mutations in the cardiac sodium or potassium channel genes that result in long QT syndrome as well as in other genes that regulate channel function.44 A recent report described important new molecular and functional evidence that implicates specific SCN5A (sodium channel gene) β subunits in SIDS pathogenesis.47 The identification of polymorphisms in genes pertinent to the embryologic origin of the autonomic nervous system in SIDS cases also lends support to the hypothesis that a genetic predisposition contributes to the etiology of SIDS. There have also been a number of reports of polymorphisms or mutations in genes that regulate inflammation,48,49 energy production,50,–,52 and hypoglycemia53 in infants who died from SIDS, but these associations require more study to determine their importance.
ISSUES RELATED TO SLEEP POSITION
The Supine Sleep Position Is Recommended for Infants to Reduce the Risk of SIDS; Side Sleeping Is Not Safe and Is Not Advised
The prone or side sleep position can increase the risk of rebreathing expired gases, resulting in hypercapnia and hypoxia.54,–,57 The prone position also increases the risk of overheating by decreasing the rate of heat loss and increasing body temperature compared with infants sleeping supine.58,59 Recent evidence suggests that prone sleeping alters the autonomic control of the infant cardiovascular system during sleep, particularly at 2 to 3 months of age,60 and can result in decreased cerebral oxygenation.61 The prone position places infants at high risk of SIDS (odds ratio [OR]: 2.3–13.1).62,–,66 However, recent studies have demonstrated that the SIDS risks associated with side and prone position are similar in magnitude (OR: 2.0 and 2.6, respectively)63 and that the population-attributable risk reported for side sleep position is higher than that for prone position.65,67 Furthermore, the risk of SIDS is exceptionally high for infants who are placed on their side and found on their stomach (OR: 8.7).63 The side sleep position is inherently unstable, and the probability of an infant rolling to the prone position from the side sleep position is significantly greater than rolling prone from the back.65,68 Infants who are unaccustomed to the prone position and are placed prone for sleep are also at greater risk than those usually placed prone (adjusted OR: 8.7–45.4).63,69,70 Therefore, it is critically important that every caregiver use the supine sleep position for every sleep period.
Despite these recommendations, the prevalence of supine positioning has remained stagnant for the last decade.71 One of the most common reasons that parents and caregivers cite for not placing infants supine is fear of choking or aspiration in the supine position.72,–,80 Parents often misconstrue coughing or gagging, which is evidence of a normal protective gag reflex, for choking or aspiration. Multiple studies in different countries have not found an increased incidence of aspiration since the change to supine sleeping.81,–,83 There is often particular concern for aspiration when the infant has been diagnosed with gastroesophageal reflux. The AAP supports the recommendations of the North American Society for Pediatric Gastroenterology and Nutrition, which state that infants with gastroesophageal reflux should be placed for sleep in the supine position, with the rare exception of infants for whom the risk of death from gastroesophageal reflux is greater than the risk of SIDS84—specifically, infants with upper airway disorders for whom airway protective mechanisms are impaired, which may include infants with anatomic abnormalities, such as type 3 or 4 laryngeal clefts, who have not undergone antireflux surgery. Elevating the head of the infant's crib while the infant is supine is not effective in reducing gastroesophageal reflux85,86; in addition, this elevation can result in the infant sliding to the foot of the crib into a position that might compromise respiration and, therefore, is not recommended.
The other reason often cited by parents for not using the supine sleep position is the perception that the infant is uncomfortable or does not sleep well.72,–,80 An infant who wakes frequently is normal and should not be perceived as a poor sleeper. Physiologic studies have found that infants are less likely to arouse when they are sleeping in the prone position.87,–,95 The ability to arouse from sleep is an important protective physiologic response to stressors during sleep,96,–,100 and the infant's ability to sleep for sustained periods might not be physiologically advantageous.
Preterm Infants Should Be Placed Supine as Soon as Possible
Infants born prematurely have an increased risk of SIDS,101,102 and the association between prone sleep position and SIDS among low birth weight infants is equal to, or perhaps even stronger than, the association among those born at term.69 Therefore, preterm infants should be placed supine for sleep as soon as their clinical status has stabilized. The task force supports the recommendations of the AAP Committee on Fetus and Newborn, which state that hospitalized preterm infants should be placed in the supine position for sleep by 32 weeks' postmenstrual age to allow them to become accustomed to sleeping in that position before hospital discharge.103 Unfortunately, preterm and very low birth weight infants continue to be more likely to be placed prone for sleep after hospital discharge.104,105 Preterm infants are placed prone initially to improve respiratory mechanics106,107; although respiratory parameters are no different in the supine or prone positions in preterm infants who are close to discharge,108 both infants and their caregivers likely become accustomed to using the prone position, which makes it more difficult to change. One study of NICU nurses found that only 50% of nurses place preterm infants supine during the transition to an open crib, and more than 20% never place preterm infants supine or will only place them supine 1 to 2 days before discharge.109 Moreover, very prematurely born infants studied before hospital discharge have longer sleep duration, fewer arousals from sleep, and increased central apneas while in the prone position.88 The task force believes that neonatologists, neonatal nurses, and other health care professionals responsible for organizing the hospital discharge of infants from NICUs should be vigilant about endorsing SIDS risk-reduction recommendations from birth. They should model the recommendations as soon as the infant is medically stable and significantly before the infant's anticipated discharge. In addition, NICUs are encouraged to develop and implement policies to ensure that supine sleeping and other safe sleep practices are modeled for parents before discharge from the hospital.
Newborn Infants Should Be Placed Supine Within the First Few Hours After Birth
Practitioners who place infants on their sides after birth in newborn nurseries continue to be a concern. The practice likely occurs because nursery staff believe that newborn infants need to clear their airways of amniotic fluid and may be less likely to aspirate while on their sides. No evidence that such fluid will be cleared more readily while in the side position exists. Finally, and perhaps most importantly, if parents observe health care professionals placing infants in the side or prone position, they are likely to infer that supine positioning is not important110 and, therefore, might be more likely to copy this practice and use the side or prone position at home.77,80,111 The AAP recommends that infants be placed on their backs as soon as they are ready to be placed in a bassinet.
Once an Infant Can Roll From the Supine to Prone and From the Prone to Supine Position, the Infant Can Be Allowed to Remain in the Sleep Position That He or She Assumes
Parents and caregivers are frequently concerned about the appropriate strategy for infants who have learned to roll over, which generally occurs at 4 to 6 months of age. As infants mature, it is more likely that they will roll. In 1 study, 6% and 12% of 16- to 23-week-old infants placed on their backs or sides, respectively, were found in the prone position; among infants aged 24 weeks or older, 14% of those placed on their backs and 18% of those placed on their sides were found in the prone position.112 Repositioning the sleeping infant to the supine position can be disruptive and might discourage the use of supine position altogether. Although data to make specific recommendations as to when it is safe for infants to sleep in the prone position are lacking, the AAP recommends that these infants continue to be placed supine until 1 year of age. If the infant can roll from supine to prone and from prone to supine, the infant can then be allowed to remain in the sleep position that he or she assumes. To prevent suffocation or entrapment if the infant rolls, soft or loose bedding should continue to be removed from the infant's sleep environment. Some caregivers use such bedding to prevent an infant from rolling, but this bedding could cause suffocation and entrapment. Parents can be reassured by the information that the incidence of SIDS begins to decline after 4 months of age (Fig 6).
Supervised, Awake Tummy Time on a Daily Basis Can Promote Motor Development and Minimize the Risk of Positional Plagiocephaly
Positional plagiocephaly, or plagiocephaly without synostosis (PWS), can be associated with supine sleeping position (OR: 2.5).113 It is most likely to result if the infant's head position is not varied when placed for sleep, if the infant spends little or no time in awake, supervised tummy time, and if the infant is not held in the upright position when not sleeping.113,–,115 Children with developmental delay and/or neurologic injury have increased rates of PWS, although a causal relationship has not been demonstrated.113,116,–,119 In healthy normal children, the incidence of PWS decreases spontaneously from 20% at 8 months to 3% at 24 months of age.114 Although data to make specific recommendations as to how often and how long tummy time should be undertaken are lacking, supervised tummy time while the infant is awake is recommended on a daily basis. Tummy time should begin as early as possible to promote motor development, facilitate development of the upper body muscles, and minimize the risk of positional plagiocephaly. The AAP clinical report on positional skull deformities120 provides additional detail on the prevention, diagnosis, and management of positional plagiocephaly.
Infants Should Sleep in a Safety-Approved Crib, Portable Crib, Play Yard, or Bassinet
Cribs should meet safety standards of the CPSC, Juvenile Product Manufacturers Association, and the ASTM International (formerly the American Society for Testing and Materials), including those for slat spacing, snugly fitting and firm mattresses, and no drop sides.121 The AAP recommends the use of new cribs, because older cribs might no longer meet current safety standards, might have missing parts, or might be incorrectly assembled. If an older crib is to be used, care must be taken to ensure that there have been no recalls on the crib model, that all of the hardware is intact, and that the assembly instructions are available.
For some families, use of a crib might not be possible for financial reasons or space considerations. In addition, parents might be reluctant to place the infant in the crib because of concerns that the crib is too large for the infant or that “crib death” (ie, SIDS) only occurs in cribs. Alternate sleep surfaces, such as portable cribs/play yards and bassinets might be more acceptable for some families, because they are smaller and more portable. Local organizations throughout the United States can help to provide low-cost or free cribs or play yards. If a portable crib/play yard or bassinet is to be used, it should meet the following CPSC guidelines: (1) sturdy bottom and wide base; (2) smooth surfaces without protruding hardware; (3) legs with locks to prevent folding while in use; and (4) firm, snugly fitting mattress.121 In addition, other AAP guidelines for safe sleep, including supine positioning and avoidance of soft objects and loose bedding, should be followed. Mattresses should be firm and should maintain their shape even when the fitted sheet designated for that model is used, such that there are no gaps between the mattress and the side of the bassinet, playpen, portable crib, or play yard. Only mattresses designed for the specific product should be used. Pillows or cushions should not be used as substitutes for mattresses or in addition to a mattress. Any fabric on the sides or a canopy should be taut and firmly attached to the frame so as not to create a suffocation risk for the infant. Portable cribs, play yards, and bassinets with vertical sides made of air-permeable material may be preferable to those with air-impermeable sides.122 Finally, parents and caregivers should adhere to the manufacturer's guidelines regarding maximum weight of infants using these products.122,123 If the product is a combination product (eg, crib/toddler bed), the manual should be consulted when the mode of use is changed.
There are no data regarding the safety of sleepers that attach to the side of an adult bed. However, there are potential safety concerns if the sleeper is not attached properly to the side of the adult bed or if the infant moves into the adult bed. Therefore, the task force cannot make a recommendation for or against the use of bedside sleepers. In addition, infants should not be placed for sleep on adult-sized beds because of the risk of entrapment and suffocation.124 Portable bed rails (railings installed on the side of the bed that are intended to prevent a child from falling off of the bed) should not be used with infants because of the risk of entrapment and strangulation.125
Car Seats and Other Sitting Devices Are not Recommended for Routine Sleep at Home or in the Hospital, Particularly for Young Infants
Some parents let their infants sleep in a car seat or other sitting device. Sitting devices include but are not restricted to car seats, strollers, swings, infant carriers, and infant slings. Parents and caregivers often use these devices, even when not traveling, because they are convenient. One study found that the average young infant spends 5.7 hours/day in a car seat or similar sitting device.126 However, there are multiple concerns about using sitting devices as a usual infant sleep location. Placing an infant in such devices can potentiate gastroesophageal reflux127 and positional plagiocephaly. Because they still have poor head control and often experience flexion of the head while in a sitting position, infants younger than 1 month in sitting devices might be at increased risk of upper airway obstruction and oxygen desaturation.128,–,132 In addition, there is increasing concern about injuries from falls resulting from car seats being placed on elevated surfaces.133,–,137 An analysis of CPSC data revealed 15 suffocation deaths between 1990 and 1997 resulting from car seats overturning after being placed on a bed, mattress, or couch.136 The CPSC also warns about the suffocation hazard to infants, particularly those who are younger than 4 months, who are carried in infant sling carriers.138 When infant slings are used for carrying, it is important to ensure that the infant's head is up and above the fabric, the face is visible, and that the nose and mouth are clear of obstructions. After nursing, the infant should be repositioned in the sling so that the head is up and is clear of fabric and the adult's body.
Room-Sharing Without Bed-Sharing Is Recommended
The terms “bed-sharing” and “cosleeping” are often used interchangeably, but they are not synonymous. Cosleeping is when parent and infant sleep in close proximity (on the same surface or different surfaces) so as to be able to see, hear, and/or touch each other.139,140 Cosleeping arrangements can include bed-sharing or sleeping in the same room in close proximity.140,141 Bed-sharing refers to a specific type of cosleeping when the infant is sleeping on the same surface with another person.140 Because the term cosleeping can be misconstrued and does not precisely describe sleep arrangements, the AAP recommends use of the terms “room-sharing” and “bed-sharing.”
The AAP recommends the arrangement of room-sharing without bed-sharing, or having the infant sleep in the parents' room but on a separate sleep surface (crib or similar surface) close to the parents' bed. There is evidence that this arrangement decreases the risk of SIDS by as much as 50%64,66,142,143 and is safer than bed-sharing64,66,142,143 or solitary sleeping (when the infant is in a separate room).53,64 In addition, this arrangement is most likely to prevent suffocation, strangulation, and entrapment, which may occur when the infant is sleeping in the adult bed. Furthermore, room-sharing without bed-sharing allows close proximity to the infant, which facilitates feeding, comforting, and monitoring of the infant.
Parent-infant bed-sharing is common. In 1 national survey, 45% of parents responded that they had shared a bed with their infant (8 months of age or younger) at some point in the preceding 2 weeks.19 In some racial/ethnic groups, the rate of routine bed-sharing might be higher.18,–,20 There are often cultural and personal reasons why parents choose to bed-share, including convenience for feeding (breastfeeding or with formula) and bonding. In addition, many parents might believe that their own vigilance is the only way that they can keep their infant safe and that the close proximity of bed-sharing allows them to maintain vigilance, even while sleeping.144 Some parents will use bed-sharing specifically as a safety strategy if the infant sleeps in the prone position21,144 or if there is concern about environmental dangers such as vermin and stray gunfire.144
Parent-infant bed-sharing continues to be highly controversial. Although electrophysiologic and behavioral studies have offered a strong case for its effect in facilitating breastfeeding145,146 and although many parents believe that they can maintain vigilance of the infant while they are asleep and bed-sharing,144 epidemiologic studies have shown that bed-sharing can be hazardous under certain conditions.147,–,150 Bed-sharing might increase the risk of overheating,151 rebreathing152 or airway obstruction,153 head covering,152,154,–,156 and exposure to tobacco smoke,157 which are all risk factors for SIDS. A recent meta-analysis of 11 studies that investigated the association of bed-sharing and SIDS revealed a summary OR of 2.88 (95% confidence interval [CI]: 1.99–4.18) with bed-sharing.158 Furthermore, bed-sharing in an adult bed not designed for infant safety exposes the infant to additional risks for accidental injury and death, such as suffocation, asphyxia, entrapment, falls, and strangulation.159,160 Infants, particularly those in the first 3 months of life and those born prematurely and/or with low birth weight, are at highest risk,161 possibly because immature motor skills and muscle strength make it difficult to escape potential threats.158 In recent years, the concern among public health officials about bed-sharing has increased, because there have been increased reports of SUIDs occurring in high-risk sleep environments, particularly bed-sharing and/or sleeping on a couch or armchair.162,–,165
There Is Insufficient Evidence to Recommend Any Bed-Sharing Situation in the Hospital or at Home as Safe; Devices Promoted to Make Bed-Sharing “Safe” Are Not Recommended
Epidemiologic studies have not found bed-sharing to be protective against SIDS and accidental suffocation for any subgroups of the population. It is acknowledged that there are some cultures for which bed-sharing is the norm and SIDS rates are low, but there are other cultures for which bed-sharing is the norm and SIDS rates are high. In general, the bed-sharing practiced in cultures with low SIDS rates is often different from that in the United States and other Western countries (eg, with firm mats on the floor, separate mat for the infant, and/or absence of soft bedding). It is statistically much more difficult to demonstrate safety (ie, no risk) in small subgroups. Breastfeeding mothers who do not smoke and have not consumed alcohol or arousal-altering medications or drugs are 1 such subgroup. Furthermore, not all risks associated with bed-sharing (eg, parental fatigue) can be controlled. The task force, therefore, believes that there is insufficient evidence to recommend any bed-sharing situation in the hospital or at home as safe. In addition, there is no evidence that devices marketed to make bed-sharing “safe” (eg, in-bed cosleepers) reduce the risk of SIDS or suffocation or are safe. Such devices, therefore, are not recommended.
There Are Specific Circumstances in Which Bed-Sharing Is Particularly Hazardous, and It Should Be Stressed to Parents That They Avoid the Following Situations at All Times
The task force emphasizes that certain circumstances greatly increase the risk with bed-sharing. Bed-sharing is especially dangerous when 1 or both parents are smokers (OR: 2.3–17.7)64,65,158,166,167; when the infant is younger than 3 months (OR: 4.7–10.4), regardless of parental smoking status64,66,143,158,168,169; when the infant is placed on excessively soft surfaces such as waterbeds, sofas, and armchairs (OR: 5.1–66.9)62,64,65,143,169; when soft bedding accessories such as pillows or blankets are used (OR: 2.8–4.1)62,170; when there are multiple bed-sharers (OR: 5.4)62; and when the parent has consumed alcohol (OR: 1.66).66,171 There is also a higher risk of SIDS when the infant is bed-sharing with someone who is not a parent (OR: 5.4).62
A retrospective series of SIDS cases indicated that mean maternal body weight was higher for bed-sharing mothers than for non–bed-sharing mothers.172 The only case-control study to investigate the relationship between maternal body weight and bed-sharing did not find an increased risk of bed-sharing with increased maternal weight.173
Infants May Be Brought Into the Bed for Feeding or Comforting but Should Be Returned to Their Own Crib or Bassinet When the Parent Is Ready to Return to Sleep
The risk of bed-sharing is higher the longer the duration of bed-sharing during the night.64,65,167,169 Returning the infant to the crib after bringing him or her into the bed for a short period of time is not associated with increased risk.65,169 Therefore, if the infant is brought into the bed for feeding, comforting, and bonding, the infant should be returned to the crib when the parent is ready for sleep. Because of the extremely high risk of SIDS, accidental suffocation, and entrapment on couches and armchairs,62,64,65,143,169 infants should not be fed on a couch or armchair when there is high risk that the parent may fall asleep.
It Is Prudent to Provide Separate Sleep Areas and Avoid Cobedding for Twins and Higher-Order Multiples in the Hospital and at Home
Cobedding of twins and other infants of multiple gestation is a frequent practice, both in the hospital setting and at home.174 However, the benefits of cobedding twins and higher-order multiples have not been established.175,–,177 Twins and higher-order multiples are often born prematurely and with low birth weight, so they are at increased risk of SIDS.101,102 Furthermore, there is increased potential for overheating and rebreathing while cobedding, and size discordance might increase the risk of accidental suffocation.176 Most cobedded twins are placed on their sides rather than supine.174 Finally, cobedding of twins and higher-order multiples in the hospital setting might encourage parents to continue this practice at home.176 Because the evidence for the benefits of cobedding twins and higher-order multiples is not compelling and because of the increased risk of SIDS and suffocation, the AAP believes that it is prudent to provide separate sleep areas for these infants to decrease the risk of SIDS and accidental suffocation.
Pillows, Quilts, Comforters, Sheepskins, and Other Soft Surfaces Are Hazardous When Placed Under the Infant or Loose in the Sleep Environment
Bedding is used in infant sleep environments for comfort and safety.178 Parents and caregivers who perceive that infants are uncomfortable on firm surfaces will often attempt to soften the surface with blankets and pillows. Parents and caregivers will also use pillows and blankets to create barriers to prevent the infant from falling off the sleep surface (usually an adult bed or couch) or to prevent injury if the infant hits the crib side. However, such soft bedding can increase the potential of suffocation and rebreathing.54,56,57,179,–,181 Pillows, quilts, comforters, sheepskins, and other soft surfaces are hazardous when placed under the infant62,147,182,–,187 or left loose in the infant's sleep area62,65,184,185,188,–,191 and can increase SIDS risk up to fivefold independent of sleep position.62,147 Several reports have also described that in many SIDS cases, the heads of the infants, including some infants who slept supine, were covered by loose bedding.65,186,187,191 It should be noted that the risk of SIDS increases 21-fold when the infant is placed prone with soft bedding.62 In addition, soft and loose bedding have both been associated with accidental suffocation deaths.149 The CPSC has reported that the majority of sleep-related infant deaths in its database are attributable to suffocation involving pillows, quilts, and extra bedding.192,193 The AAP recommends that infants sleep on a firm surface without any soft or loose bedding. Pillows, quilts, and comforters should never be in the infant's sleep environment. Specifically, these items should not be placed loose near the infant, between the mattress and the sheet, or under the infant. Infant sleep clothing that is designed to keep the infant warm without the possible hazard of head covering or entrapment can be used in place of blankets; however, care must be taken to select appropriately sized clothing and to avoid overheating. If a blanket is used, it should be thin and tucked under the mattress so as to avoid head or face covering. These practices should also be modeled in hospital settings.
Wedges and Positioning Devices Are not Recommended
Wedges and positioning devices are often used by parents to maintain the infant in the side or supine position because of claims that these products reduce the risk for SIDS, suffocation, or gastroesophageal reflux. However, these products are frequently made with soft, compressible materials, which might increase the risk of suffocation. The CPSC has reports of deaths attributable to suffocation and entrapment associated with wedges and positioning devices. Most of these deaths occurred when infants were placed in the prone or side position with these devices; other incidents have occurred when infants have slipped out of the restraints or rolled into a prone position while using the device.2,194 Because of the lack of evidence that they are effective against SIDS, suffocation, or gastroesophageal reflux and because there is potential for suffocation and entrapment, the AAP concurs with the CPSC and the US Food and Drug Administration in warning against the use of these products. If positioning devices are used in the hospital as part of physical therapy, they should be removed from the infant sleep area well before discharge from the hospital.
Bumper Pads and Similar Products Are not Recommended
Bumper pads and similar products that attach to crib slats or sides are frequently used with the thought of protecting infants from injury. Initially, bumper pads were developed to prevent head entrapment between crib slats.195 However, newer crib standards that require crib slat spacing to be less than 2⅜ inches have obviated the need for crib bumpers. In addition, infant deaths have occurred because of bumper pads. A recent report by Thach et al,196 who used CPSC data, found that deaths attributed to bumper pads were from 3 mechanisms: (1) suffocation against soft, pillow-like bumper pads; (2) entrapment between the mattress or crib and firm bumper pads; and (3) strangulation from bumper pad ties. However, the CPSC believes that there were other confounding factors, such as the presence of pillows and/or blankets, that might have contributed to many of the deaths in this report.2 Thach et al196 also analyzed crib injuries that might have been prevented by bumper pad use and concluded that the use of bumper pads only prevents minor injuries. A more recent study of crib injuries that used data from the CPSC National Electronic Injury Surveillance System concluded that the potential benefits of preventing minor injury with bumper pad use were far outweighed by the risk of serious injury such as suffocation or strangulation.197 In addition, most bumper pads obscure infant and parent visibility, which might increase parental anxiety.195 There are other products that attach to crib sides or crib slats that claim to protect infants from injury. However, there are no published data that support these claims. Because of the potential for suffocation, entrapment, and strangulation and lack of evidence to support that bumper pads or similar products that attach to crib slats or sides prevent injury in young infants, the AAP does not recommend their use.
PRENATAL AND POSTNATAL EXPOSURES (INCLUDING SMOKING AND ALCOHOL)
Pregnant Women Should Seek and Obtain Regular Prenatal Care
There is substantial epidemiologic evidence that links a lower risk of SIDS for infants whose mothers obtain regular prenatal care.198,–,200 Women should seek prenatal care early in the pregnancy and continue to obtain regular prenatal care during the entire pregnancy.
Smoking During Pregnancy, in the Pregnant Woman's Environment, and in the Infant's Environment Should Be Avoided
Maternal smoking during pregnancy is a major risk factor in almost every epidemiologic study of SIDS.201,–,204 Smoke in the infant's environment after birth is a separate major risk factor in a few studies,202,205 although separating this variable from maternal smoking before birth is problematic. Thirdhand smoke refers to residual contamination from tobacco smoke after the cigarette has been extinguished206; there is no research to date on the significance of thirdhand smoke with regards to SIDS risk. Smoke exposure adversely affects infant arousal207,–,213; in addition, smoke exposure increases risk of preterm birth and low birth weight, both of which are risk factors for SIDS. The effect of tobacco smoke exposure on SIDS risk is dose-dependent. Aside from sleep position, smoke exposure is the largest contributing risk factor for SIDS.149 It is estimated that one-third of SIDS deaths could be prevented if all maternal smoking during pregnancy were eliminated.214,215 The AAP supports the elimination of all tobacco smoke exposure, both prenatally and environmentally.216,217
Avoid Alcohol and Illicit Drug Use During Pregnancy and After the Infant's Birth
Several studies have specifically investigated the association of SIDS with prenatal and postnatal exposure to alcohol or illicit drug use, although substance abuse often involves more than 1 substance and it is difficult to separate these variables from each other and from smoking. However, 1 study of Northern Plains American Indians found that periconceptional maternal alcohol use (adjusted OR: 6.2 [95% CI: 1.6–23.3]) and maternal first-trimester binge drinking (adjusted OR: 8.2 [95% CI: 1.9–35.3])218 were associated with increased SIDS risk independent of prenatal cigarette smoking exposure. Another study from Denmark, which was based on prospective data about maternal alcohol use, also found a significant relationship between maternal binge drinking and postneonatal infant mortality, including SIDS.219
Postmortem studies of Northern Plains American Indian infants revealed that prenatal cigarette smoking was significantly associated with decreased serotonin receptor binding in the brainstem. In this study, the association of maternal alcohol drinking in the 3 months before or during pregnancy was of borderline significance on univariate analysis but was not significant when prenatal smoking and case-versus-control status were in the model.39 However, this study had limited power for multivariate analysis because of its small sample size. One study found an association of SIDS with heavy alcohol consumption in the 2 days before the death.220 Although some studies have found a particularly strong association when alcohol consumption occurs in combination with bed-sharing,64,–,66,221 other studies have not found interaction between bed-sharing and alcohol to be significant.167,222
Studies investigating the relationship of illicit drug use and SIDS have focused on specific drugs or illicit drug use in general. In utero exposure to opiates (primarily methadone and heroin) has been shown in retrospective studies to be associated with an increased risk of SIDS.223,224 With the exception of 1 study that did not show increased risk,225 population-based studies have generally shown an increased risk with in utero cocaine exposure.226,–,228 However, these studies did not control for confounding factors. A prospective cohort study found the SIDS rate to be significantly increased for infants exposed in utero to methadone (OR: 3.6 [95% CI: 2.5–5.1]), heroin (OR: 2.3 [95% CI: 1.3–4.0]), methadone and heroin (OR: 3.2 [95% CI: 1.2–8.6]), and cocaine (OR: 1.6 [95% CI: 1.2–2.2]), even after controlling for race/ethnicity, maternal age, parity, birth weight, year of birth, and maternal smoking.229 In addition, a meta-analysis of studies that investigated an association between in utero cocaine exposure and SIDS found an increased risk of SIDS to be associated with prenatal exposure to cocaine and illicit drugs in general.230
Breastfeeding Is Recommended
Earlier epidemiologic studies were not consistent in demonstrating a protective effect of breastfeeding on SIDS*; some studies found a protective effect,67,239,240 and others did not.† Because many of the case-control studies demonstrated a protective effect of breastfeeding against SIDS in univariate analysis but not when confounding factors were taken into account,62,184,198,231,238 these results suggested that factors associated with breastfeeding, rather than breastfeeding itself, are protective. However, newer published reports support the protective role of breastfeeding on SIDS when taking into account potential confounding factors.243,–,245 Studies do not distinguish between nursing and expressed human milk. In the Agency for Healthcare Research and Quality's “Evidence Report on Breastfeeding in Developed Countries,”243 multiple outcomes, including SIDS, were examined. Six studies were included in the SIDS-breastfeeding meta-analysis, and in both unadjusted and adjusted analysis, ever breastfeeding was associated with a lower risk of SIDS (summary OR: 0.41 [95% CI: 0.28–0.58]; adjusted summary OR: 0.64 [95% CI: 0.51–0.81]). The German Study of Sudden Infant Death, the largest and most recent case-control study of SIDS, found that exclusive breastfeeding at 1 month of age halved the risk of SIDS (adjusted OR: 0.48 [95% CI: 0.28–0.82]). At all ages, control infants were breastfed at higher rates than SIDS victims, and the protective effect of partial or exclusive breastfeeding remained statistically significant after adjustment for confounders.244 A recent meta-analysis that included 18 case-control studies revealed an unadjusted summary OR for any breastfeeding of 0.40 (95% CI: 0.35–0.44). Seven of these studies provided adjusted ORs, and on the basis of these studies, the pooled adjusted OR remained statistically significant at 0.55 (95% CI: 0.44–0.69) (Fig 9).245 The protective effect of breastfeeding increased with exclusivity, with a univariable summary OR of 0.27 (95% CI: 0.24–0.31) for exclusive breastfeeding of any duration.245
Currently in the United States, 73% of mothers initiate breastfeeding, and 42% and 21% are still breastfeeding at 6 and 12 months, respectively.246 Non-Hispanic black mothers are least likely to initiate or to still be breastfeeding at 6 and 12 months (54%, 27%, and 12%, respectively), whereas Asian/Pacific Islander mothers initiate and continue breastfeeding more than other groups (81%, 52%, and 30%, respectively). Rates for initiating and continuing breastfeeding at 6 and 12 months for non-Hispanic white mothers are 74%, 43%, and 21%; rates for Hispanic mothers are 80%, 45%, and 24%; and rates for American Indian/Alaskan Native mothers are 70%, 37%, and 19%, respectively.
Physiologic sleep studies have found that breastfed infants are more easily aroused from sleep than their formula-fed counterparts.247,248 In addition, breastfeeding results in a decreased incidence of diarrhea, upper and lower respiratory infections, and other infectious diseases249 that are associated with an increased vulnerability to SIDS and provides overall immune system benefits from maternal antibodies and micronutrients in human milk.250,251 Exclusive breastfeeding for 6 months has been found to be more protective against infectious diseases compared with exclusive breastfeeding to 4 months of age and partial breastfeeding thereafter.249
If a Breastfeeding Mother Brings the Infant Into the Adult Bed for Nursing, the Infant Should Be Returned to a Separate Sleep Surface When the Mother Is Ready for Sleep
Several organizations promote the practice of mother-infant bed-sharing (ie, sleeping in the same bed) as a way of facilitating breastfeeding.142,252,253 Breastfeeding is a common reason given by mothers for bed-sharing with their infants.254 Studies have found an association between bed-sharing and longer duration of breastfeeding, but their data cannot determine a temporal relationship (ie, it is not known whether bed-sharing promotes breastfeeding or if breastfeeding promotes bed-sharing, or if women who prefer 1 practice are also likely to prefer the other).255 Although bed-sharing may facilitate breastfeeding, it is not essential for successful breastfeeding.256,257 Furthermore, 1 case-control study found that the risk of SIDS while bed-sharing was similar regardless of breastfeeding status, which indicates that the benefits of breastfeeding do not outweigh the increased risk associated with bed-sharing.258
Consider Offering a Pacifier at Nap Time And Bedtime
Several studies62,66,167,231,259,–,262 have found a protective effect of pacifiers on the incidence of SIDS, particularly when used at the time of last sleep. Two meta-analyses revealed that pacifier use decreased the risk of SIDS by 50% to 60% (summary adjusted OR: 0.39 [95% CI: 0.31–0.50]263; summary unadjusted OR: 0.48 [95% CI: 0.43–0.54]264). Two later studies not included in these meta-analyses reported equivalent or even larger protective associations.265,266 The mechanism for this apparent strong protective effect is still unclear, but lowered arousal thresholds, favorable modification of autonomic control during sleep, and maintaining airway patency during sleep have been proposed.247,267,–,270 It is common for the pacifier to fall from the mouth soon after the infant falls asleep; even so, the protective effect persists throughout that sleep period.247,271 Two studies have shown that pacifier use is most protective when used for all sleep periods.169,266 However, these studies also showed increased risk of SIDS when the pacifier was usually used but not used the last time the infant was placed for sleep; the significance of these findings is yet unclear.
Although some SIDS experts and policy-makers endorse pacifier use recommendations that are similar to those of the AAP,272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275,–,277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well-designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278,279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2–5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration. In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier. At 3 months, there were no differences in breastfeeding rates between the 2 groups; 85.8% of infants in the offer-pacifier group were exclusively breastfeeding compared with 86.2% in the not-offered group.282 The AAP policy statement on breastfeeding and the use of human milk includes a recommendation that pacifiers can be used during breastfeeding, but implementation should be delayed until breastfeeding is well established.283
Some dental malocclusions have been found more commonly among pacifier users than nonusers, but the differences generally disappeared after pacifier cessation.284 In its policy statement on oral habits, the American Academy of Pediatric Dentistry states that nonnutritive sucking behaviors (ie, fingers or pacifiers) are considered normal for infants and young children and that, in general, sucking habits in children to the age of 3 years are unlikely to cause any long-term problems.285 There is an approximate 1.2- to 2-fold increased risk of otitis media associated with pacifier use, particularly between 2 and 3 years of age.286,287 The incidence of otitis media is generally lower in the first year of life, especially the first 6 months, when the risk of SIDS is the highest.288,–,293 However, pacifier use, once established, may persist beyond 6 months, thus increasing the risk of otitis media. Gastrointestinal infections and oral colonization with Candida species were also found to be more common among pacifier users than nonusers.289,–,291
The literature on infant digit-sucking and SIDS is extremely limited. Only 1 case-control study from the Netherlands has reported results.262 This study did not find an association between usual digit-sucking (reported as “thumb-sucking”) and SIDS risk (OR: 1.38 [95% CI: 0.35–1.51]), but the wide CI suggests that there was insufficient power to detect a significant association.
OVERHEATING, FANS, AND ROOM VENTILATION
Avoid Overheating and Head Covering in Infants
There is clear evidence that the risk of SIDS is associated with the amount of clothing or blankets on an infant and the room temperature.182,218,294,295 Infants who sleep in the prone position have a higher risk of overheating than do supine sleeping infants.182 It is unclear whether the relationship to overheating is an independent factor or merely a reflection of the increased risk of SIDS and suffocation with blankets and other potentially asphyxiating objects in the sleeping environment. Head covering during sleep is of particular concern. In a recent systematic review, the pooled mean prevalence of head covering among SIDS victims was 24.6% compared with 3.2% among control infants.154 It is not known whether the risk associated with head covering is attributable to overheating, hypoxia, or rebreathing.
There has been some suggestion that room ventilation may be important. One study found that bedroom heating, compared with no bedroom heating, increases SIDS risk (OR: 4.5),235 and another study has also demonstrated a decreased risk of SIDS in a well-ventilated bedroom (windows and doors open) (OR: 0.4).296 In 1 study, the use of a fan seemed to reduce the risk of SIDS (adjusted OR: 0.28 [95% CI: 0.10–0.77]).297 However, because of the possibility of recall bias, the small sample size of controls using fans (n = 36), a lack of detail about the location and types of fans used, and the weak link to a mechanism, this study's results should be interpreted with caution. On the basis of available data, the task force cannot make a recommendation on the use of a fan as a SIDS risk-reduction strategy.
Although Swaddling May Be Used as a Strategy to Calm the Infant and Encourage Use of Supine Position, There Is Not Enough Evidence to Recommend It as a Strategy for Reducing the Risk of SIDS
Many cultures and newborn nurseries have traditionally used swaddling, or wrapping the infant in a light blanket, as a strategy to soothe infants and, in some cases, encourage sleep in the supine position. Swaddling, when done correctly, can be an effective technique to help calm infants and promote sleep.298 Some have argued that swaddling can alter certain risk factors for SIDS, thus reducing the risk of SIDS. For instance, it has been suggested that the physical restraint associated with swaddling may prevent infants placed supine from rolling to the prone position.299 One study's results suggested a decrease in SIDS rate with swaddling if the infant was supine,182 but it was notable that there was an increased risk of SIDS if the infant was swaddled and placed in the prone position.182 Although a recent study found a 31-fold increase in SIDS risk with swaddling, the analysis was not stratified according to sleep position.171 Although it may be more likely that parents will initially place a swaddled infant supine, this protective effect may be offset by the 12-fold increased risk of SIDS if the infant is either placed or rolls to the prone position when swaddled.182,300 Moreover, there is no evidence that swaddling reduces bed-sharing or use of unsafe sleep surfaces, promotes breastfeeding, or reduces maternal cigarette smoking.
There is some evidence that swaddling might cause detrimental physiologic consequences. For example, it can cause an increase in respiratory rate,301 and tight swaddling can reduce the infant's functional residual lung capacity.299,302,303 Tight swaddling can also exacerbate hip dysplasia if the hips are kept in extension and adduction.304,–,307 This is particularly important, because some have advocated that the calming effects of swaddling are related to the “tightness” of the swaddling. In contrast, “loose” or incorrectly applied swaddling could result in head covering and, in some cases, strangulation if the blankets become loose in the bed. Swaddling may also possibly increase the risk of overheating in some situations, especially when the head is covered or the infant has an infection.308,309 However, a recent study found no increase in abdominal skin temperature when infants were swaddled in a light cotton blanket from the shoulders down.302
Impaired arousal has often been postulated as a mechanism that contributes to SIDS, and several studies have investigated the relationship between swaddling, arousal, and sleep patterns in infants. Physiologic studies have demonstrated that, in general, swaddling decreases startling,301 increases sleep duration, and decreases spontaneous awakenings.310 Swaddling also decreases arousability (ie, increases cortical arousal thresholds) to a nasal pulsatile air-jet stimulus, especially in infants who are easily arousable when not swaddled but less so in infants who have high arousal thresholds when not swaddled.301 One study found decreased arousability in infants at 3 months of age who were not usually swaddled and then were swaddled but found no effect on arousability in routinely swaddled infants.301 In contrast, another group of investigators showed decreased arousal thresholds310 and increases in autonomic (subcortical) responses311 to an auditory stimulus when swaddled. Thus, although swaddling clearly promotes sleep and decreases the number of awakenings, the effects on arousability to an external stimulus remain unclear. There is accumulating evidence, however, that there are only minimal effects of routine swaddling on arousal. In addition, there have been no studies investigating the effects of swaddling on arousal to more relevant stimuli such as hypoxia or hypercapnia.
In summary, it is recognized that swaddling is one of many child care practices that can be used to calm infants and promote sleep. However, there is insufficient evidence to recommend routine swaddling as a strategy for reducing the incidence of SIDS. Moreover, as many have advocated, swaddling must be correctly applied to avoid possible hazards such as hip dysplasia, head covering, and strangulation. It is important to note that swaddling does not reduce the necessity to follow recommended safe sleep practices.
IMMUNIZATIONS AND SIDS
Infants Should Be Immunized in Accordance With Recommendations of the AAP and Centers for Disease Control and Prevention
The incidence of SIDS peaks at a time when infants are receiving numerous immunizations. Case reports of a cluster of deaths shortly after immunization with diphtheria-tetanus-pertussis in the late 1970s created concern of a possible causal relationship between vaccinations and SIDS.312,–,315 Case-control studies were performed to evaluate this temporal association. Four of the 6 studies found no relationship between diphtheria-tetanus-pertussis vaccination and subsequent SIDS,316,–,319 and results of the other 2 studies suggested a temporal relationship but only in specific subgroup analysis.320,321 In 2003, the Institute of Medicine of the National Academy of Sciences reviewed available data and concluded that “[t]he evidence favors rejection of a causal relationship between exposure to multiple vaccinations and SIDS.”322 Additional subsequent large population case-control trials consistently have found vaccines to be protective against SIDS323,–,325; however, confounding factors (social, maternal, birth, and infant medical history) might account for this protective effect.326 It also has been theorized that the decreased SIDS rate immediately after vaccination was attributable to infants being healthier at time of immunization, or “the healthy vaccinee effect.”327 Recent illness would both place infants at higher risk of SIDS and make them more likely to have immunizations deferred.328
Recent studies have attempted to control for confounding by social, maternal, birth, and infant medical history.323,325,328 In a meta-analysis, Vennemann et al328 found a multivariate summary OR for immunizations and SIDS to be 0.54 (95% CI: 0.39–0.76), which indicates that the risk of SIDS is halved by immunization. The evidence continues to show no causal relationship between immunizations and SIDS and suggests that vaccination may have a protective effect against SIDS.
HOME MONITORS, SIDS, AND APPARENT LIFE-THREATENING EVENTS
There Is no Evidence That Apparent Life-Threatening Events Are Precursors to SIDS, and Infant Home Monitors Should Not Be Used as a Strategy for Preventing SIDS
For many years it was believed that apparent life-threatening events were the predecessors of SIDS, and home apnea monitors were used as a strategy for preventing SIDS.329 However, there is no evidence that home monitors are effective for this purpose.330,–,333 The task force concurs with the AAP Committee on Fetus and Newborn, which has recommended that infant home monitoring not be used as a strategy to prevent SIDS, although it can be useful for some infants who have had an apparent life-threatening event.334
POTENTIAL TOXICANTS AND SIDS
There Is no Evidence Linking Various Toxicants to SIDS
Many theories link various toxicants and SIDS. Currently, no studies have substantiated a causal relationship between metals, such as silver, cadmium, cobalt, lead, or mercury, and SIDS.335,–,337 Although an ecological study found correlation of the maximal recorded nitrate levels of drinking water with local SIDS rates in Sweden,338 no case-control study has demonstrated a relationship between nitrates in drinking water and SIDS. Furthermore, an expert group in the United Kingdom analyzed data pertaining to a hypothesis that SIDS is related to toxic gases, such as antimony, phosphorus, or arsenic, being released from mattresses339,340 and found the toxic-gas hypothesis to be unsubstantiated.341 Finally, 2 case-control studies found that wrapping mattresses in plastic to reduce toxic gas emission did not protect against SIDS.191,342
Newborn Hearing Screens Should Not Be Used as a Screening Test for SIDS
A single, small, retrospective case-control study examined the use of newborn transient evoked otoacoustic emission hearing screening tests as a tool for identifying infants at subsequent risk of SIDS.343 Infants who subsequently died from SIDS did not fail their hearing tests but, compared with controls, showed a decreased signal-to-noise ratio score in the right ear only (at frequencies of 2000, 3000, and 4000 Hz). Methodologic concerns have been raised about the validity of the study methods used in this study,344,345 and these results have not been substantiated by others. A larger but non–peer-reviewed report of hearing screening data in Michigan revealed no relationship between hearing screening test results and SIDS cases.346 Until additional data are available, hearing screening should not be considered as a valid screening tool for determining which infants might be at subsequent risk of SIDS. Furthermore, an increased risk of SIDS should not be inferred from an abnormal hearing screen result.
Educational and Intervention Campaigns Are Often Effective in Altering Practice
Intervention campaigns for SIDS have been extremely effective, especially with regard to avoidance of prone positioning.347 Furthermore, there is evidence that primary care–based educational interventions, particularly those that address caregiver concerns and misconceptions about safe sleep recommendations, can be effective in altering practice. For instance, addressing concerns about infant comfort, choking, and aspiration while the infant is sleeping prone is helpful.348,349 Similar interventions for improving behavior of medical and nursing staff and child care providers have shown that these professionals have similar concerns about the supine sleep position.350,–,353 Primary care providers should be encouraged to develop quality improvement initiatives to improve adherence with safe sleep recommendations among their patients.
Media and Manufacturers Should Follow Safe Sleep Guidelines in Their Messaging and Advertising
A recent study found that, in magazines targeted toward childbearing women, more than one-third of pictures of sleeping infants and two-thirds of pictures of infant sleep environments portrayed unsafe sleep positions and sleep environments.354 Media exposures (including movie, television, magazines, newspapers, and Web sites), manufacturer advertisements, and store displays affect individual behavior by influencing beliefs and attitudes. Frequent exposure to health-related media messages can affect individual health decisions,355,356 and media messages have been quite influential in decisions regarding sleep position.77,80 Media and advertising messages contrary to safe sleep recommendations may create misinformation about safe sleep practices. Safe sleep messages should be reviewed, revised, and reissued at least every 5 years to address the next generation of new parents and products on the market.
The AAP's recommendations for a safe infant sleeping environment to reduce the risk of both SIDS and other sleep-related infant deaths are specified in the accompanying policy statement.4
Task Force on Sudden Infant Death Syndrome, 2010–2011
Rachel Y. Moon, MD, Chairperson
Robert A. Darnall, MD
Michael H. Goodstein, MD
Fern R. Hauck, MD, MS
Marian Willinger, PhD
Eunice Kennedy Shriver National Institute for Child Health and Human Development
Carrie K. Shapiro-Mendoza, PhD, MPH
Centers for Disease Control and Prevention
The task force acknowledges the contributions provided by others to the collection and interpretation of data examined in preparation of this report. The task force is particularly grateful for the report submitted by Dr Suad Wanna-Nakamura (CPSC) and for the assistance of Sarah McKinnon, PhD, MPH, and Cristina Rodriguez-Hart, MPH, with the statistics and graphs.
The guidance in this report does not indicate an exclusive course of treatment or serve as a standard of medical care. Variations, taking into account individual circumstances, may be appropriate.
All technical reports from the American Academy of Pediatrics automatically expire 5 years after publication unless reaffirmed, revised, or retired at or before that time.
- CPSC —
- Consumer Product Safety Commission
- AAP —
- American Academy of Pediatrics
- SIDS —
- sudden infant death syndrome
- SUID —
- sudden unexpected infant death
- ICD —
- International Classification of Diseases
- ASSB —
- accidental suffocation and strangulation in bed
- 5-HT —
- OR —
- odds ratio
- CI —
- confidence interval
- Copyright © 2011 by the American Academy of Pediatrics