INTRODUCTION: Bronchial provocation tests (BPTs) assist in diagnosing and evaluating the curative effect of asthma.
OBJECTIVE: The objective of this study was to compare the sensitivity, reliability, and safety between 2 tidal breathing methods in BPT.
METHODS: Sixty-five infants, including those with asthma and chronic cough, were divided into groups A and B at random. BPT by the improvement of tidal breathing method was performed in group A (35 infants), and the traditional tidal breathing method was performed in group B (30 infants). In 10 normal infants (control subjects), the traditional tidal breathing method was used. In addition, we observed arterial oxygen saturation, respiratory system resistance, %T-PF, percent of tidal volume of peak tidal expiratory flow, and lung symptoms and monitored the vital sign and adverse effects of the test.
RESULTS: Results of the BPTs for all children with asthma were positive. The positive rates for children with chronic cough were 69.57% and 60.00% in groups A and B, respectively; the results of BPTs in control subjects were completely negative. There was no significant difference in positive rate, and both methods had a similar degree of airway hyperresponsiveness; however, in group A, the effect was of shorter duration and the test was more efficient. During the BPT, 6 infants in group A and 9 in group B had cough, but none exhibited an acute asthma episode.
CONCLUSIONS: The improved tidal breathing method, used as a BPT, outweighs the traditional method in sensitivity, specificity, efficiency of detection, dosage of medicine, and safety.
Submitted by Ying Huang
- Copyright © 2008 by the American Academy of Pediatrics