INTRODUCTION: Various pathways, such as person-person, fecal-oral, and oral-oral transmission, play a role in transmission of Helicobacter pylori infection. It can be transferred from mother to infant in either the perinatal or postnatal periods.
OBJECTIVE: The aim of this prospective study was to determine the course of H pylori infection in mother-infant pairs in early years of life.
METHODS: Forty-eight mother-child pairs were followed for 12 months. H pylori and hepatitis A virus immunoglobulin G levels were measured in maternal sera, infant sera, and breast-milk samples at birth and in breast-milk samples and infant sera at follow-up visits.
RESULTS: At birth, the seropositivity for H pylori was 81.25% and hepatitis A was 68.75% in breast milk and 95.8% in maternal and infant sera for both microorganisms. Although there was a decrease in seropositivities for both agents in both infant sera and breast milk at the age of 9 months, an increase was observed in the twelfth month.
CONCLUSIONS: High seroprevalence rates of H pylori and hepatitis A virus and similar monthly changes in seroprevalence could be indicators of the same transmission routes.
Submitted by Selda Fatma Hizel Bulbul
- Copyright © 2008 by the American Academy of Pediatrics