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    Pediatrics
    November 2003, VOLUME 112 / ISSUE 5
    ELECTRONIC ARTICLES

    Increased Prevalence of Familial Autoimmunity in Probands With Pervasive Developmental Disorders

    Thayne L. Sweeten, Suzanne L. Bowyer, David J. Posey, Gary M. Halberstadt, Christopher J. McDougle
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    Tables

    • Table 1.

      Descriptive Data for Probands and Response Rates to the Questionnaire*

      PDDAutoimmuneHealthy
      Mean age (y ± SD)10.2 ± 4.2†10.3 ± 4.8†6.5 ± 4.0
      Sex: male/female83/1831/7060/41
      Race
       White969492
       Black254
       Other325
      Response rates‡101/196 (52%)101/135 (75%)101/182 (55%)
      • ↵* Each group consists of 101 families.

      • ↵† Compared with healthy: t = 7.13, P < .0001.

      • ‡ Response rate indicates the proportion of questionnaires completed of the number distributed to each group.

    • Table 2.

      Mean Number of First- or Second-Degree Family Members With Autoimmune Disorders per Family and Number of Families in Each Group With a Specific Autoimmune Disorder*

      PDDAutoimmuneHealthy
      Mean Number per Family1.87 ± 1.6†‡1.44 ± 1.5§0.93 ± 1.1
      Hypothyroidism/ Hashimoto’s thyroiditis36‖¶1114
      Rheumatic fever23#106
      Multiple sclerosis721
      • ↵* Each group consists of 101 families.

      • ↵† Compared with autoimmune: t = 2.03; P = .03.

      • ↵‡ Compared with healthy: t = 4.90; P = .000003.

      • ↵§ Compared with healthy: t = 2.72; P = .01.

      • ↵‖ Compared with autoimmune: χ2 = 18.06; P = .00002.

      • ↵¶ Compared with healthy: χ2 = 13.21; P = .0003.

      • ↵# Compared with healthy: χ2 = 12.31; P = .0005.

    • Table 3.

      Number of Families That Have at Least One Specified Member With an Autoimmune Disorder*

      PDDAutoimmuneHealthy
      Parent31†2812
      Mother261710
      Father5132
      Sibling862
      Brother520
      Sister342
      Grandparent554835
      Grandmother473528
      Grandfather232214
      Uncle17116
      Aunt252517
      Cousin12108
      • ↵* Each group consists of 101 families.

      • ↵† Compared with healthy: χ2 = 10.97; P = .0009.

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    Increased Prevalence of Familial Autoimmunity in Probands With Pervasive Developmental Disorders
    Thayne L. Sweeten, Suzanne L. Bowyer, David J. Posey, Gary M. Halberstadt, Christopher J. McDougle
    Pediatrics Nov 2003, 112 (5) e420; DOI: 10.1542/peds.112.5.e420

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    Increased Prevalence of Familial Autoimmunity in Probands With Pervasive Developmental Disorders
    Thayne L. Sweeten, Suzanne L. Bowyer, David J. Posey, Gary M. Halberstadt, Christopher J. McDougle
    Pediatrics Nov 2003, 112 (5) e420; DOI: 10.1542/peds.112.5.e420
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