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Important Clinical Manifestations of SCD During Childhood and Adolescence
↵* Potential cause of mortality.
SCD: Neonatal Screening and Diagnostic Test Results
Table shows typical results—exceptions occur. Rare forms of SCD, such as SD-Punjab, SO-Arab, SC-Harlem, Sδβ-thalassemia, SE, and SLepore, not included.
↵* Hemoglobins reported in order of quantity (eg, FSA = F>S>A).
↵† Normal or reference range of MCV is > 70 fL at age 6–12 mo; lower limits of reference range subsequently increase with age to 80 fL during adolescence.
↵‡ HbA2 results vary somewhat depending on laboratory methodology.
↵§ HbSS with coexistent α-thalassemia may show decreased MCV and HbA2 >3.6%; however, neonatal screening results from such infants usually show Bart’s hemoglobin.
↵‖ NA = not applicable—quantity of HbA2 usually not measured in presence of HbC.
↵¶ Quantity of HbA at birth is sometimes insufficient for detection.
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