Get Involved: The Pediatrics editorial board is seeking candidates for three general board positions and one fellowship position. See the 2017 Nominations Application to apply by Friday, February 24, 2017.
TABLE 2.

Number of Immunogenic Proteins and Polysaccharides Contained in Vaccines Over the Past 100 Years

1900196019802000
VaccineProteinsVaccineProteinsVaccineProteinsVaccineProteins/Polysaccharides
Smallpox*∼200Smallpox∼200Diphtheria1Diphtheria1
Total∼200Diphtheria1Tetanus1Tetanus1
Tetanus1WC-Pertussis∼3000AC-Pertussis¶¶2–5
WC-Pertussis§∼3000Polio15Polio15
Polio15Measles10Measles10
Total∼3217Mumps#9Mumps9
Rubella**5Rubella5
Total∼3041Hib††2
Varicella‡‡69
Pneumococcus§ §8
Hepatitis B‖Verbar;1
Total123–126
  • * Vaccinia vaccine: Goebel SJ, Johnson GP, Perkus ME, et al. Virology. 1990;179:247–266.

  • Diphtheria toxoid: MMWR Morb Mortal Wkly Rep. 1991 (August);40:1–28.

  • Tetanus toxoid: MMWR Morb Mortal Wkly Rep. 1991 (August);40:1–28.

  • § Whole cell pertussis vaccine: Number estimated from genome size. The sequence of Bordetella pertussis Tohama I strain will soon be completed at the Sanger Center in Great Britain.

  • Polio vaccine: Wimmer E, Nomoto A. Biologicals. 1993;21:349–356; Kitamura N, Semler BL, Rothberg PG, et al. Nature. 1981;291:547–553; Five proteins per poliovirus virion and 3 poliovirus strains in the inactivated poliovirus vaccine (IPV).

  • Measles vaccine: Griffen D, Bellini WL. Measles virus. In: Fields BN, ed. Knipe DM, Howley PM, et al, eds. Philadelphia, PA: Lipincott-Raven Publishers; 1996.

  • # Mumps vaccine: Elango N, Varsanyi TM, Kovamees J, Norrby E. J Gen Virol. 1988;69:2893–2900.

  • ** Rubella vaccine. Hofmann J, Gerstenberger S, Lachmann I, et al. Virus Res. 2000;68:155–160.

  • †† Conjugate Haemophilus influenzae type b vaccine: MMWR Morb Mortal Wkly Rep. 1991 (January);40:1–7.

  • ‡Dagger; Varicella vaccine: Cohen JI. Infect Dis Clin North Am. 1996;10:457–468.

  • §§ Streptococcus pneumoniae vaccine: MMWR Morb Mortal Wkly Rep. 2000;49:1–29.

  • ‖‖ Hepatitis B vaccine: MMWR Morb Mortal Wkly Rep. 1991 (November);40:1–25.

  • ¶¶ Acellular pertussis vaccine: MMWR Morb Mortal Wkly Rep. 1997 (March);46:1–25.