Table 5.
Drugs That Have Been Associated With Significant Effects on Some Nursing Infants and Should Be Given to Nursing Mothers With Caution*
| Drug | Reported Effect | Reference No. |
|---|---|---|
| Acebutolol | Hypotension; bradycardia; tachypnea | 116 |
| 5-Aminosalicylic acid | Diarrhea (1 case) | 117–119 |
| Atenolol | Cyanosis; bradycardia | 120–124 |
| Bromocriptine | Suppresses lactation; may be hazardous to the mother | 125, 126 |
| Aspirin (salicylates) | Metabolic acidosis (1 case) | 127–129 |
| Clemastine | Drowsiness, irritability, refusal to feed, high-pitched cry, neck stiffness (1 case) | 130 |
| Ergotamine | Vomiting, diarrhea, convulsions (doses used in migraine medications) | 131 |
| Lithium | One-third to one-half therapeutic blood concentration in infants | 132–134 |
| Phenindione | Anticoagulant: increased prothrombin and partial thromboplastin time in 1 infant; not used in United States | 135 |
| Phenobarbital | Sedation; infantile spasms after weaning from milk containing phenobarbital, methemoglobinemia (1 case) | 136–140 |
| Primidone | Sedation, feeding problems | 136, 137 |
| Sulfasalazine (salicylazosulfapyridine) | Bloody diarrhea (1 case) | 141 |
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↵* Blood concentration in the infant may be of clinical importance.
