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ARTICLES:
Ashok Kumar, Roopali Mittal, Hari Dev Khanna, and Sriparna Basu
Free Radical Injury and Blood-Brain Barrier Permeability in Hypoxic-Ischemic Encephalopathy
Pediatrics 2008; 0: peds.2008-0269v1-727 [Abstract] [Full text] [PDF]
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[Read eLetters] Reoxygenation after hypoxia
Heikki Savolainen   (2 September 2008)

Reoxygenation after hypoxia 2 September 2008
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Heikki Savolainen,
Professor
Dept. of Occup. Safety & Hlth., Tampere, Finland

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Re: Reoxygenation after hypoxia

heikki.savolainen{at}stm.fi Heikki Savolainen

Dear Editor,

This very interesting article is entirely biologically plausible. The results can be compared with effects of histotoxic hypoxia (1,2).

This makes the therapeutic options complex as hyperoxia in the reoxygenation period may aggravate the lipid peroxidation in a clinical (3) and experimental setting (4).

1. Savolainen H, Kurppa K, Tenhunen R, et al. Biochemical effects of carbon monoxide poisoning in rat brain with special reference to blood carboxyhemoglobib and cerebral cytochrome oxidase activity. Neurosci Lett, 1980; 19: 319.

2. Rafalowska U, Zitting A, Savolainen H. Metabolic changes in rat brain synaptosomes after exposure to sulfide in vivo. Toxicol Lett, 1986; 34: 193.

3. Scheinkestel Cd, Bailey M, Myles PS, et al. Hyperbaric or normobaric oxygen for acute carbon monoxide poisoning: a randomised controlled clinical trial. Med j Austr, 1999; 170: 203.

4. Nerudova J, Gut I, Savolainen H. Consequences of acrylonitrile metabolism in rat hepatocytes: Effects on lipid peroxidation and viability of cells. Environ Res, 1988; 46: 133.

Conflict of Interest:

None declared