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- STATE-OF-THE-ART REVIEW ARTICLES:
Richard H. Haas, Sumit Parikh, Marni J. Falk, Russell P. Saneto, Nicole I. Wolf, Niklas Darin, and Bruce H. Cohen
- Mitochondrial Disease: A Practical Approach for Primary Care Physicians
Pediatrics 2007; 120: 1326-1333
[Abstract]
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eLetters published:
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Mitochondrial pathology
- Heikki Savolainen
(4 December 2007)
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Mitochondrial pathology |
4 December 2007 |
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Heikki Savolainen, Prof. Dept. of Occup. Safety & Hlth., Tampere, Finland
Send letter to journal:
Re: Mitochondrial pathology
heikki.savolainen{at}stm.fi Heikki Savolainen
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Besides the classical aspects of clinical pathology in mitochondrial
energy metabolism so elegantly reviewed in this work, it may be
interesting to regard the additional roles of succinate dehydrogenase
(SDH) at the complex II of the respiratory chain. Its activity can be
inhibited by toxicants, like malonic acid, 3-nitropropionic acid or
alkoxyacetic acids (1) which leads to deranged electron flow in the
respiratory chain. Accumulating succinate also inhibits the inactivation
of hypoxia inducible factor by the proteasome. Acquired and inherited
diminution of SDH has an important role e.g. in the epigenetic malignant
transformation (2). Thus, mitochondria have central roles also in other
acute and chronic diseases in addition to the classical neuromuscular
syndromes.
1 Liesivuori J, Laitinen J, Savolainen H. 1999. Rat model for renal
effects of 2-alkoxyalcohols and their acetates. Arch Toxicol 73: 229-232.
2 Baysal BE. A recurrent stop-codon mutation in succinate
dehydrogenases B gene in normal peripheral blood and childhood T-cell
acute leukemia. 2007. Plos ONE 2: e436.
Conflict of Interest:
None declared |
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