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ARTICLE:
Jodi K. Jackson, Deborah J. Biondo, Janice M. Jones, Pamala J. Moor, Stephen D. Simon, Robert T. Hall, and Howard W. Kilbride
Can an Alternative Umbilical Arterial Catheter Solution and Flush Regimen Decrease Iatrogenic Hemolysis While Enhancing Nutrition? A Double-Blind, Randomized, Clinical Trial Comparing an Isotonic Amino Acid With a Hypotonic Salt Infusion
Pediatrics 2004; 114: 377-383 [Abstract] [Full text] [PDF]
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[Read eLetters] Hemolysis, free hemogloblin is a scavenger for nitric oxide
Dennis Costakos, Jodi K Jackson, MD   (3 May 2005)

Hemolysis, free hemogloblin is a scavenger for nitric oxide 3 May 2005
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Dennis Costakos,
neonatologist
Mayo Health system,
Jodi K Jackson, MD

Send letter to journal:
Re: Hemolysis, free hemogloblin is a scavenger for nitric oxide

costakos.dennis{at}mayo.edu Dennis Costakos, et al.

I commend Dr. Jackson and colleagues for the important work performed first in vitro studies, and most recently as a clinical study. Free hemoglobin is a scavenger for Nitric Oxide, and this may be a cause of human disease through the consumption of nitric oxide. Dennis T. Costakos, MD Mayo Health System LaCrosse Wisconsin References:

Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA. 2005 Apr 6;293(13):1653-62. Review.

Conflict of Interest:

None declared