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ELECTRONIC ARTICLE:
Richard C. Redman, IV, John Bernard Miller, Margaret Hood, and James DeMaio
Trimethoprim-Induced Aseptic Meningitis in an Adolescent Male
Pediatrics 2002; 110: e26 [Abstract] [Full text] [PDF]
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[Read eLetters] (TMP-SMX) CNS disease
leslie l barton   (21 August 2002)

(TMP-SMX) CNS disease 21 August 2002
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leslie l barton,
prof peds
Univ AZ Schl Med

Send letter to journal:
Re: (TMP-SMX) CNS disease

llb{at}peds.arizona.edu leslie l barton

Your publication regarding the association of drugs with CNS disease, specifically trimethoprim (as well as TMP-SMX), is an timely reminder of an entity infrequently considered by pediatricians. Too often, when causative agents are sought but not found, the etiology of a central nervous system or even a systemic illness, is ascribed to 'a virus.' Adverse drug reactions may have many presentations. We previously reported the association of TMP-SMX with central nervous system and systemic inflammatory response, a report we wish to call to your attention (Pediatr Infect Dis J 14:76,1995).