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ARTICLE:
Ernani Miura, Renato S. Procianoy, Cristina Bittar, Clarissa S. Miura, Maurício S. Miura, Cíntia Mello, and Robert D. Christensen
A Randomized, Double-Masked, Placebo-Controlled Trial of Recombinant Granulocyte Colony-Stimulating Factor Administration to Preterm Infants With the Clinical Diagnosis of Early-Onset Sepsis
Pediatrics 2001; 107: 30-35 [Abstract] [Full text] [PDF]
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[Read eLetters] Study blinding
HD Dellagrammaticas   (3 January 2001)

Study blinding 3 January 2001
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HD Dellagrammaticas,
Associate Professor in Neonatal Paediatrics
NICU,2nd Department of Paediatrics University of Athens

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Re: Study blinding

hdellagr{at}ath.forthnet.gr HD Dellagrammaticas

Editor,

We read with interest the study by Miura et al (1). However we were puzzled by a phrase in the 'Treatment protocol' in which 'Partcipants, investigators, and haelth care providers were blinded to the study assignment'.

As the administration of rG-CSF would result in relatively acute rise of neutrophils and other indices, it is difficult for us to comprehend how blinding was achieved, perticularly in the case of health care providers.

We think that some clarification on this matter is warranted.

Dr. H.D. Dellagrammaticas MD, FRCPCH Dr. N. Iacovidou

References

1. Miura E, Procianoy RS, Bittar C, Miura CS, Miura MS, Mello C, Christensen RD A randomized, double masked, placebo-controlled trial of recombinant granulacyte colony-stimulating factor administration to preterm infants with clinical diagnosis of early-onset sepsis