Published online July 3, 2006
PEDIATRICS Vol. 118 No. 1 July 2006, pp. 201-206 (doi:10.1542/peds.2005-1856)
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Utility of Childhood Non–High-Density Lipoprotein Cholesterol Levels in Predicting Adult Dyslipidemia and Other Cardiovascular Risks: The Bogalusa Heart Study

Sathanur R. Srinivasan, PhDa, Maria G. Frontini, PhDb, Jihua Xu, MDa and Gerald S. Berenson, MDa

a Tulane Center for Cardiovascular Health and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, Louisiana
b Department of Public Health, Eastern Virginia Medical School, Norfolk, Virginia

OBJECTIVE. This study sought to examine the usefulness of non–high-density lipoprotein cholesterol levels in predicting future dyslipidemia and other cardiovascular risk in adulthood.

METHODS. The study sample consisted of a longitudinal cohort of subjects (n = 1163; 30.1% black and 55.4% female) who participated in the Bogalusa Heart Study both as children at 5 to 14 years of age and as adults 27 years later.

RESULTS. The childhood level of non–high-density lipoprotein cholesterol, like low-density lipoprotein cholesterol, was the best predictor of the adulthood level; the next best predictor for both variables was the change in BMI from childhood to adulthood. Furthermore, those in the age-, race-, and gender-specific top quartile, compared with those in the bottom quartile, of non–high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels in childhood were 4.5 and 3.5 times more likely, respectively, to develop adult dyslipidemia, independent of baseline BMI and BMI change after 27 years. Although, at equivalent cutoff points, childhood high-risk versus acceptable-risk status for both lipid measures was associated significantly with increased prevalence of obesity and adverse levels of low-density lipoprotein cholesterol and triglycerides in adulthood, only childhood non–high-density lipoprotein cholesterol high-risk status was associated with increased prevalence of low high-density lipoprotein cholesterol levels, hyperinsulinemia, and hyperglycemia (marginal).

CONCLUSIONS. Adverse levels of non–high-density lipoprotein cholesterol versus low-density lipoprotein cholesterol in childhood not only equally persist over time and better predict adult dyslipidemia but also are related to nonlipid cardiovascular risk factors in adulthood.

Key Words: non–high-density lipoprotein cholesterol • low-density lipoprotein cholesterol • childhood • adulthood • tracking • coronary artery disease risk

Abbreviations: CAD—coronary artery disease • HDL—high-density lipoprotein • LDL—low-density lipoprotein

Accepted Jan 17, 2006.


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