PEDIATRICS Vol. 106 No. 4 October 2000, pp. 828
COMMENTARY:
Commentary on Cerebral Intravascular Oxygenation Correlates With
Mean Arterial Pressure in Critically Ill Premature Infants
| The first 20% of the full text of this article appears below. |
Since the original work of Wigglesworth
and Pape1 and Perlman et al,2 fluctuations in
cerebral perfusion have been recognized as a major causal factor in the
pathogenesis of germinal matrix hemorrhage-intraventricular hemorrhage
(GMH-IVH) in the very preterm infant. Lou and
colleagues,3 in their pioneering studies using the
133Xenon clearance technique, first suggested
that some critically ill infants might have a
pressure-passive cerebral circulation, thus allowing abrupt changes in
arterial blood pressure to be transmitted directly to the brain
microvasculature.
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