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PEDIATRICS Vol. 106 No. 4 October 2000, pp. 828

COMMENTARY:
Commentary on Cerebral Intravascular Oxygenation Correlates With Mean Arterial Pressure in Critically Ill Premature Infants

The first 20% of the full text of this article appears below.

Since the original work of Wigglesworth and Pape1 and Perlman et al,2 fluctuations in cerebral perfusion have been recognized as a major causal factor in the pathogenesis of germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) in the very preterm infant. Lou and colleagues,3 in their pioneering studies using the 133Xenon clearance technique, first suggested that some critically ill infants might have a pressure-passive cerebral circulation, thus allowing abrupt changes in arterial blood pressure to be transmitted directly to the brain microvasculature. . . . [Full Text of this Article]


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