Published online December 31, 2007
PEDIATRICS Vol. 121 No. 1 January 2008, pp. 223-224 (doi:10.1542/peds.2007-3069)

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LETTER TO THE EDITOR

Efficacy of the Pentavalent Rotavirus Vaccine in Subjects After 1 or 2 Doses in the Rotavirus Efficacy and Safety Trial: In Reply

American Academy of Pediatrics Committee on Infectious Diseases
Joseph A. Bocchini, Jr, MD, Chairperson We thank Dr Bernstein for his letter regarding clarification of data discrepancies between the policy statement "Prevention of Rotavirus Disease: Guidelines for Use of Rotavirus Vaccine"¹ by the American Academy of Pediatrics (AAP) Committee on Infectious Diseases and an Infectious Disease Society of America abstract² on the same subject.

We concur that the post–dose-1 efficacy estimates in the abstract are quite different from those quoted in the AAP guideline. However, the data presented in the AAP guideline are accurate. They are the result of further posthoc analysis of data from Merck & Co's Rotavirus Efficacy and Safety Trial, which was completed after submission of the abstract. These updated data were presented at the 2006 Infectious Disease Society of America meeting and were included in the policy statement to best provide pediatricians with an estimate of efficacy should a child receive fewer than 3 doses of vaccine. A manuscript is currently in preparation that will detail the methodology and the results of the data analysis.

REFERENCES

1. American Academy of Pediatrics, Committee on Infectious Diseases. Prevention of rotavirus disease: guidelines for use of rotavirus vaccine. Pediatrics. 2007;119 :171 –182[Abstract/Free Full Text]
2. Vesikari T, Matson D, Dennehy P, et al. Efficacy of the pentavalent rotavirus vaccine in subjects after 1 or 2 doses in the Rotavirus Efficacy & Safety Trial (REST) [abstract]. Presented at: the 44th annual meeting of the Infectious Disease Society of America; October 12–15, 2006; Toronto, Ontario, Canada

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PEDIATRICS (ISSN 1098-4275). ©2008 by the American Academy of Pediatrics

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This Article Extract Full Text (PDF) Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services E-mail this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to My File Cabinet Download to citation manager Request Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bocchini, J. A. Search for Related Content PubMed Articles by Bocchini, J. A., Jr Related Collections Infectious Disease & Immunity Social Bookmarking                         What's this?