Published online January 2, 2007
PEDIATRICS Vol. 119 No. 1 January 2007, pp. 226 (doi:10.1542/peds.2006-3001)
This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnston, C. C.
Right arrow Articles by Boyer, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnston, C. C.
Right arrow Articles by Boyer, K.
Related Collections
Right arrow Therapeutics & Toxicology
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

LETTER TO THE EDITOR

How Much Sucrose Is Too Much Sucrose?

C. Celeste Johnston, DEd, RN
Francoise Filion, MS, RN
School of Nursing

Laurie Snider, PhD, OT
Catherine Limperopoulos, MSc, OT
School of Physical and Occupational Therapy

Annette Majnemer, PhD, OT
Department of Neurology

Ermelinda Pelausa, MD
Department of Pediatrics
McGill University
Montreal, Quebec, Canada H3A 2T5

Heather Cake, MA
Sharon Stone, RN
IWK-Grace Health Sciences Centre
Halifax, Nova Scotia, Canada B3K 6R8

Adam Sherrard, BSc, MSc
University of Ottawa
Ottawa, Ontario, Canada K1N 6N5

Kristina Boyer, MSc(A), RN
Canuck Place Children's Hospice
Vancouver, British Columbia, Canada V6H 3V1

To the Editor.—

Four years ago we published a study that reported negative developmental sequelae after high doses of sucrose in infants <31 weeks' gestational age.1 After numerous inquiries, we decided to return to the raw data set to determine if we could find an answer to the question, "How much sucrose is too much?" We conducted a secondary analysis with this question in mind.

Infants who scored <2 SDs below published normative data of the Neurodevelopmental Assessment of the Preterm Infant (NAPI)2,3 were compared with infants within the reference range on motor development and vigor and alertness and orientation at 32, 36, and 40 weeks on the number of doses of sucrose received over the study week. Severity of illness at birth, based on Clinical Risk Index for Babies (CRIB)4 scores, was controlled for in the analysis. Infants who received ≤10 doses of sucrose over 24 hours were less at risk for poorer neurodevelopmental scores.

REFERENCES

  1. Johnston CC, Filion F, Snider L, et al. Routine sucrose analgesia during the first week of life in neonates younger than 31 weeks' postconceptional age. Pediatrics. 2002;110 :523 –528[Abstract/Free Full Text]
  2. Korner AF, Kraemer HC, Reade EP, Forrest T, Dimiceli S, Thom VA. A methodological approach to developing an assessment procedure for testing the neurobehavioral maturity of preterm infants. Child Dev. 1987;58 :1478 –1487[CrossRef][Web of Science][Medline]
  3. Korner AF, Thom VA. Neurobehavioral Assessment of the Preterm Infant: Manual. San Diego, CA: Brace, Harcourt, Jovanovich, Inc; 1990
  4. The International Neonatal Network. The CRIB (clinical risk index for babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units [published correction appears in Lancet. 1993;342:626]. Lancet. 1993;342 :193 –198[CrossRef][Web of Science][Medline]
PEDIATRICS (ISSN 1098-4275). ©2007 by the American Academy of Pediatrics

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?



This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnston, C. C.
Right arrow Articles by Boyer, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnston, C. C.
Right arrow Articles by Boyer, K.
Related Collections
Right arrow Therapeutics & Toxicology
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?