Published online May 1, 2006
PEDIATRICS Vol. 117 No. 5 May 2006, pp. 1857 (doi:10.1542/peds.2006-0067)
This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Related articles in Pediatrics
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lee, P.-I.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lee, P.-I.
Related Collections
Right arrow Infectious Disease & Immunity

Ampicillin and Cefotaxime as a Risk Factor of Neonatal Death

Ping-Ing Lee, MD, PhD
Department of Pediatrics
National Taiwan University Hospital
Taipei 10002, Taiwan

To the Editor.

By a retrospective review of 128914 records of inborn neonates, Clark et al1 concluded that for neonates receiving ampicillin, the concurrent use of cefotaxime during the first 3 days of life is an independent risk factor of neonatal death. The authors pointed out the limitations of such a retrospective review. In addition, for both univariate and multivariate analyses, patients with either sepsis or meningitis were put into a single category, which may create an important confounding factor. Table 2 of their article showed that patients having received cefotaxime therapy were more likely to have some severe complications, including liver dysfunction, renal failure, cardiac arrest, etc. These important confounding variables were not included in the multivariate analysis. If the study results are to be convincing, these confounding variables should be added to the model.

REFERENCE

  1. Clark RH, Bloom BT, Spitzer AR, Gerstmann DR. Empiric use of ampicillin and cefotaxime, compared with ampicillin and gentamicin, for neonates at risk for sepsis is associated with an increased risk of neonatal death. Pediatrics. 2006;117 :67 –74[CrossRef][ISI][Medline]
PEDIATRICS (ISSN 1098-4275). ©2006 by the American Academy of Pediatrics

Related articles in Pediatrics:

Ampicillin and Cefotaxime as a Risk Factor of Neonatal Death: In Reply
Reese H. Clark, Barry T. Bloom, Dale R. Gerstmann, and Alan R. Spitzer
Pediatrics 2006 117: 1857-1858. [Extract] [Full Text]  




This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Related articles in Pediatrics
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lee, P.-I.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lee, P.-I.
Related Collections
Right arrow Infectious Disease & Immunity