Published online November 1, 2005
PEDIATRICS Vol. 116 No. 5 November 2005, pp. e694-e701 (doi:10.1542/peds.2005-0568)
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jea, A.
Right arrow Articles by Scott, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jea, A.
Right arrow Articles by Scott, R. M.
Related Collections
Right arrow Surgery

ELECTRONIC ARTICLE

Moyamoya Syndrome Associated With Down Syndrome: Outcome After Surgical Revascularization

Andrew Jea, MD*, Edward R. Smith, MD*, Richard Robertson, MD{ddagger} and R. Michael Scott, MD*

* Departments of Neurosurgery
{ddagger} Radiology, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts


   ABSTRACT
TOP
 ABSTRACT
METHODS
 RESULTS
 DISCUSSION
 CONCLUSIONS
 REFERENCES
 
Objectives. This study was undertaken to describe the clinical, radiologic, and angiographic features of moyamoya syndrome in a surgical series of children and adults with Down syndrome. We wished to define the features of moyamoya syndrome associated with Down syndrome and to determine the results of surgical revascularization among these patients at early and late follow-up times.

Methods. We reviewed the clinical, radiologic, and angiographic records of all patients with moyamoya syndrome associated with Down syndrome, as a subset of a previously reported, consecutive series of patients who underwent cerebral revascularization surgery with a standardized surgical procedure, pial synangiosis, between January 1, 1985, and June 30, 2004.

Results. Of 181 patients with moyamoya syndrome from the initial series who were treated surgically during the study period, 16 patients had Down syndrome (10 female patients and 6 male patients). The average age at onset was 9.3 years (range: 1–29 years); the average age at the time of surgery was 9.8 years (range: 2–29 years). Although the presenting symptoms were transient ischemic attacks for 10 patients and strokes for 6 patients, computed tomographic and/or MRI scans demonstrated bilateral infarctions for 9 patients and unilateral infarctions for 6, with only 1 patient having no imaging evidence of a previous stroke. No cases presented with intracerebral hemorrhage. Preoperative angiography showed the presence of bilateral moyamoya syndrome changes for all patients, including posterior circulation involvement for 8 patients. Surgical treatment included pial synangiosis for all patients, although 1 patient underwent a superficial temporal artery-middle cerebral artery bypass in the contralateral hemisphere. Surgical complications included symptomatic subdural hematomas requiring evacuation, at 48 days and 54 days postoperatively (2 cases), seizures (2 cases), and strokes within 30 days after surgery, at 1 day and 7 days postoperatively (2 cases). Late clinical and radiologic follow-up data (average: 67.6 months; range: 6–146 months) demonstrated no worsening in neurologic status for any patient except for 1 patient who developed a seizure disorder with associated chronic hypocalcemia; she was totally dependent at the 10-year follow-up evaluation, despite no evidence of new infarction since her surgery. There was no clinical or radiologic evidence of new infarction for any patient in late follow-up evaluations. Postoperative angiography, conducted 1 year after surgery for 11 patients, revealed radiologic evidence of good to excellent cerebral revascularization in 85% of the surgically treated hemispheres. Patients were maintained on lifetime aspirin therapy.

Conclusions. The clinical, radiologic, and angiographic features of moyamoya syndrome associated with Down syndrome seem comparable to those of primary moyamoya disease. Cerebral revascularization surgery with the pial synangiosis technique seems to confer long-lasting protection against additional strokes in this patient population. The presence of moyamoya syndrome should be considered in the evaluation of patients with Down syndrome who present with transient ischemic attack-like symptoms.

Key Words: moyamoya disease • moyamoya syndrome • Down syndrome • stroke • pial synangiosis • surgery

Abbreviations: ADL, activities of daily living • MRA, magnetic resonance angiography

Moyamoya syndrome is a chronic, occlusive, cerebrovascular disorder of unknown pathogenesis that is characterized by progressive stenosis of the bilateral supraclinoid internal carotid arteries, with concomitant formation of tortuous arterial collateral vessels at the base of the brain, which reconstitute distal branches of the cerebral circulation. In this study, we sought to compare the clinical, radiologic, and angiographic features of the moyamoya phenomenon associated with Down syndrome with those of primary moyamoya disease and to explore possible reasons for the high frequency of moyamoya syndrome in the Down syndrome population. We wished to determine the efficacy of a specific revascularization technique, pial synangiosis, in preventing additional episodes of cerebral ischemia and progressive disability among these patients.


   METHODS
TOP
 ABSTRACT
 METHODS
RESULTS
 DISCUSSION
 CONCLUSIONS
 REFERENCES
 
We reviewed a previously reported, consecutive, surgical series of patients with moyamoya syndrome who underwent pial synangiosis between January 1, 1985, and June 30, 2004, to identify patients with Down syndrome.1 The charts of these patients were reviewed retrospectively, to determine gender and age at presentation, symptoms, results of radiologic studies (including computed tomography, MRI/magnetic resonance angiography [MRA], and cerebral arteriography), perioperative and late complications, length of follow-up period, and long-term clinical and radiologic outcomes. The functional status of each patient was graded with a modified Rankin outcome scale (0 = no symptoms; 1 = minor symptoms not affecting lifestyle; 2 = minor handicap but independent in activities of daily living [ADL]; 3 = requiring some help with ADL; 4 = requiring substantial help with ADL; 5 = totally dependent).


   RESULTS
TOP
 ABSTRACT
 METHODS
 RESULTS
DISCUSSION
 CONCLUSIONS
 REFERENCES
 
Patients
Sixteen patients with moyamoya syndrome associated with Down syndrome were treated surgically during the study period. Their clinical features are listed in Table 1. The average age at presentation was 9.3 years (range: 1–29 years), with a median of 7.8 years; the average age at the time of surgical treatment was 9.8 years (range: 2–29 years), with a median of 8.0 years. There were 6 male patients and 10 female patients.


View this table:
[in this window]
[in a new window]
  		TABLE 1. Clinical and Radiologic Summary of 16 Patients With Moyamoya Syndrome and Associated Down Syndrome

 
Associated Systemic Manifestations
The most common associated systemic abnormalities were congenital cardiac anomalies (11 cases), gastrointestinal anomalies (4 cases), and endocrine disturbances (3 cases). Other significant associated abnormalities included acute lymphocytic leukemia (2 cases) and atlantoaxial instability (1 cases).

Clinical Features
All patients presented with symptoms consistent with cerebral ischemia, with chief complaints of transient ischemic episodes for 10 patients (62.5%) and stroke for 6 patients (37.5%).

Preoperative Radiologic and Angiographic Features
Despite the clinical presentations noted above, all except 1 patient demonstrated the presence of infarction on preoperative computed tomographic and/or MRI scans. Preoperative angiograms were available for review for 12 patients (24 hemispheres) and showed typical bilateral involvement of the supraclinoid internal carotid artery and its major branches for all patients; in addition, 8 patients demonstrated posterior circulation involvement (Fig 1). Because of severe behavioral disturbances, 1 patient was treated surgically on the basis of MRI/MRA findings only and did not undergo formal angiography.


Figure 1
View larger version (178K):
[in this window]
[in a new window]
  		Fig 1. Preoperative angiogram, demonstrating an injection of the right external carotid artery. The long posterior branch of the superficial temporal artery (arrow) should be noted.

 
Surgical Treatment
All patients in this series underwent pial synangiosis to revascularize the affected hemisphere, although 1 adult patient also underwent a superficial temporal artery-middle cerebral artery anastomosis in 1 of her surgically treated hemispheres. Pial synangiosis is a modification of the encephaloduroarteriosynangiosis described originally by Matsushima and Inaha.2 A branch of the superficial temporal artery is dissected intact from the scalp, and this healthy vessel is then sutured to the pial surface of the brain after a craniotomy is performed. The vessel is left intact; once the bone is replaced, the vessel passes under the skull proximally to contact the brain and then comes back out to the scalp distally. Subsequent ingrowth of blood vessels from the donor vessel and dural margins occurs over several months after the operation and results in collateral blood flow to the ischemic brain tissue.3 The average follow-up period was 67.6 months (range: 6–146 months).

Complications
Complications from surgical treatment in the series (Table 2) included delayed subdural hematoma formation that required evacuation for patients 4 and 7 (at 48 and 54 days after surgery, respectively), postoperative seizures for patients 11 and 13, and new infarctions within 30 days after surgery for patients 9 and 16.


View this table:
[in this window]
[in a new window]
  		TABLE 2. Complications Related to Surgical Revascularization for 16 Patients With Moyamoya Syndrome and Down Syndrome

 
Clinical Outcomes
Clinical outcomes were available for 15 patients (Table 3). Fourteen patients showed no worsening in neurologic function. Eight of these patients were thought to have demonstrated improvement in their neurologic examination results and/or recovery from preexisting deficits (Rankin scale scores of 0 or 1); 6 demonstrated no changes in their preexisting deficits and were graded in Rankin categories 2 or 3. One patient who developed a chronic seizure disorder in the setting of chronic hypocalcemia exhibited deterioration during the follow-up period, despite no evidence of new infarction on MRI scans, and was given a Rankin scale score of 4. All patients were maintained on chronic aspirin therapy (81 mg daily).


View this table:
[in this window]
[in a new window]
  		TABLE 3. Clinical Outcomes After Surgery for 15 Patients With Moyamoya Syndrome and Down Syndrome

 
Radiologic and Angiographic Outcomes
One-year follow-up angiograms were available for 11 of 16 patients (21 hemispheres); 20 of the 21 hemispheres (95%) developed new collateral circulation via the synangiosis (Figs 1 and 2). Annual postoperative MRI/MRA scans were available for 10 patients; none of the patients demonstrated evidence of new infarction.


Figure 2
View larger version (162K):
[in this window]
[in a new window]
  		Fig 2. Postoperative angiogram, demonstrating an injection of the same right external carotid artery as seen in Fig 1, 1 year after surgery. The site of pial synangiosis, with a hypertrophied superficial temporal artery and abundant collateral vessel development (large arrow), should be noted. In addition, enlarged middle meningeal branches, also supplying collateral branches to the cortex (small arrows), can be seen.

 

   DISCUSSION
TOP
 ABSTRACT
 METHODS
 RESULTS
 DISCUSSION
CONCLUSIONS
 REFERENCES
 
Reports of Moyamoya Syndrome
The moyamoya arteriopathy was first described in a case report from Japan by Takeuchi and Shimizu4 in 1957. The typical angiographic appearance of the small, fragile, basal, collateral vessels prompted Suzuki and Takaku5 to use the Japanese word "moyamoya," meaning "hazy, cloudy, or puff of smoke," to define the vasculopathy. The disease is usually bilateral, although unilateral presentations of the disorder have been described.6,7 In much of the Japanese literature, the primary idiopathic form, "moyamoya disease," has been distinguished from an "associated" form, "moyamoya syndrome," in which the arterial changes are seen among patients with various syndromes or other disease processes.8–46 However, the clinical and radiologic features of the associated and idiopathic forms seem identical.1,32

The pathogenesis of moyamoya syndrome is unknown. The age at onset of symptoms of moyamoya syndrome shows a bimodal distribution, peaking in the first decade at age 5 and in the fourth decade at age 34. The majority of children with moyamoya syndrome present with ischemic symptoms, whereas adults present with intraparenchymal, intraventricular, or subarachnoid hemorrhage, as well as stroke and transient ischemic attacks. A fixed, unilateral, neurologic deficit is the most common initial finding,47 although alternating hemiplegia may be seen for some patients.48 Seizures and involuntary movement disorders may also occur in the pediatric population.49

There are relatively few reports of the occurrence of moyamoya syndrome in association with Down syndrome, although moyamoya syndrome has been reported to occur with a higher frequency in Down syndrome than in the general pediatric population.16 There have been 47 previous cases of moyamoya syndrome in association with Down syndrome reported in the world literature, including cases from Japan, the United States, Brazil, and Italy; there have been 26 cases reported in the English-language literature to date.

The prognosis of patients with moyamoya syndrome seems to depend on neurologic status at the time of diagnosis and surgical therapy.49 It seems that untreated children experience continued, progressive, neurologic decline secondary to increasing stroke burden. Children with large unilateral or bilateral infarctions involving the dominant hemisphere, suffered at an early age, frequently are severely developmentally delayed and may have chronic seizure disorders. In contrast, patients with multiple small infarctions or a single large infarction in the nondominant hemisphere may have a satisfactory long-term prognosis if additional strokes can be prevented. For this reason, for our own patients we have recommended that revascularization surgery be performed early in the course of the disease, before the development of multiple infarctions.50 Given the relentless progressive nature of moyamoya syndrome, we think that early intervention is justified.

Clinical Features of Our Patient Series
The usual peak of onset of moyamoya syndrome in childhood is during the first decade of life.7 Our larger clinical series had an average age of onset of 7.1 years,1 and the average age of onset of this series was 2 years older, ie, 9.3 years, with a range from 1 year to 29 years. The slightly older age of onset may reflect the greater difficulty of detecting symptoms in the Down syndrome population; in addition, transient neurologic symptoms among patients with Down syndrome may not be evaluated aggressively. We found that such symptoms were attributed frequently to sequelae of congenital cardiac anomalies or to a possible seizure disorder. Unilateral weakness has been reported as the most common clinical presentation for moyamoya disease,5,51 and 13 of our 16 patients presented with hemiparesis or hemiplegia, with 6 of those 13 patients presenting with alternating hemiparesis or hemiplegia. The youngest patient in our series with moyamoya syndrome and Down syndrome was 2.5 years; the age at onset of his first ischemic episode, which was thought at the time to be secondary to complications from previous surgery for a congenital cardiac anomaly, was 1 year. The youngest reported patient with moyamoya syndrome and Down syndrome was 20 months of age.14 The preponderance of female patients (10 patients) over male patients (6 patients) in this Down syndrome series, with a ratio of 1.7:1, is comparable to a reported incidence ratio in the general moyamoya syndrome population of 1.4:1.51 The overall long-term mortality rate for moyamoya disease has been reported variably as 4.3% to 13%.7,52 The surgical mortality rate in our series was 0%, and no patients died during the follow-up period, which ranged from 6 months to 12 years.

Surgical Treatment
The most widely used procedure for the surgical treatment of moyamoya syndrome among children is probably encephaloduroarteriosynangiosis,41 which was first described by Matsushima et al.53 Every patient in our series underwent pial synangiosis (described above), but one 29-year-old patient had sufficiently large superficial temporal artery and middle cerebral artery branches that an anastomosis between the 2 could be conducted in one of the surgically treated hemispheres. The postoperative arteriograms obtained after the 2 procedures indicated excellent hemispheric collateral vessels on each side, which suggests that the observable collateral vessels resulting from the procedures are comparable.

Complications
Throughout the follow-up period, ranging from 6 months to 12 years, no strokes occurred outside a 30-day perioperative period for any of our patients. Two patients experienced early postoperative infarctions, with significant neurologic deficits; however, at the time of the most recent follow-up evaluations, the patients had recovered completely from their deficits. Other complications included formation of subdural hematomas for 2 patients (1 spontaneous and 1 posttraumatic) and new seizures for 2 patients. Both subdural hematomas required surgical evacuation, but neither patient experienced long-term sequelae from the hematomas. This patient population is particularly susceptible to this complication, because of the prior craniotomy, preexisting cortical atrophy, and chronic aspirin therapy.

Clinical Outcomes
Motor recovery in moyamoya syndrome associated with Down syndrome was good despite multiple and/or bilateral infarctions, consistent with the prognosis reported for primary moyamoya disease after surgical revascularization. Recovery among patients with primary moyamoya disease treated surgically was found to be good for 57%, fair for 22%, and poor for 20%.54 In our previously reported series of 143 patients treated surgically with pial synangiosis,1 nearly 75% of patients were leading independent and normal lives. In this Down syndrome series, good recovery was seen for 53%, fair recovery with persistent neurologic deficits was seen for 40%, and poor recovery with worsening neurologic status was seen for 7%. The good recovery from stroke among patients with moyamoya syndrome associated with Down syndrome is remarkable. Stroke recovery mechanisms seem to rely on neuronal adaptation, including synaptogenesis, axonal and dendritic growth, and changes in neurotransmitters; the neuronal abnormalities found in Down syndrome, including atrophy of cortical dendrites and reduced synaptogenesis,13 would be anticipated to inhibit such recovery.

Radiologic and Angiographic Outcomes
Striking development of collateral circulation from synangiosis was seen in 95% of surgically treated hemispheres on 1-year postoperative angiograms. All patients remained clinically and radiologically stroke-free during long-term follow-up monitoring, despite evidence of angiographic progression of moyamoya syndrome in 42% of surgically treated hemispheres. The revascularization surgery for these patients seemed to be the major factor in preventing cerebral infarctions in the presence of worsening stenosis of major cerebral arteries.

Mechanisms of Pathogenesis
The association of Down syndrome with moyamoya syndrome is still not understood. The fact that so many children with Down syndrome have cardiac structural anomalies suggests that the genetic defect in Down syndrome may also lead to disturbances in the formation or growth of vascular structures elsewhere the body. Patients with Down syndrome have been noted to have an increased number of retinal vessels, compared with gender- and age-matched normal control subjects. These vessel are said to have a "spoke-like" pattern, with frequent early branching, and this observation lends support to the postulate that there is a general vascular dysplasia in Down syndrome.55 Other vascular abnormalities described in Down syndrome include abnormal nail-bed capillary loops and renovascular hypertension.56 Neuropathologic investigation of a child with Down syndrome who did not have moyamoya syndrome revealed significant structural abnormalities in vessels of the circle of Willis, ie, irregular internal elastic membrane surrounding regions of marked endothelial hyperplasia, which again suggests a possible underlying structural change in the cerebral arteries of children with moyamoya syndrome and Down syndrome.30

One report suggests that protein C deficiency among children with Down syndrome leads to thromboembolism and recurrent strokes.57 Protein C deficiencies were not investigated systematically in our patient series, however. One patient in our series (patient 16) became symptomatic after starting treatment with an oral contraceptive, a known risk factor for stroke in many patient populations and a medication specifically contraindicated for patients with moyamoya syndrome.

The presence of autoimmune processes and autoantibodies among patients with trisomy 21 suggests the postulate that the presence of moyamoya syndrome in Down syndrome might result from an immunologic disturbance of some type. Idiopathic moyamoya syndrome has been associated with antiphospholipid antibodies,29 and our series included 3 patients with endocrine abnormalities, including 1 patient with both autoimmune hypothyroidism (Hashimoto’s thyroiditis) and non–insulin-dependent (type 2) diabetes mellitus and 2 patients with hyperthyroidism (Graves’ disease).

Down syndrome may, through its constellation of associated systemic manifestations, expose patients to the cumulative effects of other associated risk factors for moyamoya syndrome and thereby increase the patients’ susceptibility to the disease. It has already been noted that certain clinical conditions are associated with moyamoya syndrome independent of Down syndrome, including congenital heart defects,21 autoimmune disorders of the thyroid,23,27,28,46 and head and neck irradiation.11,25,33,37 Two of our patients with Down syndrome developed acute lymphocytic leukemia before the onset of clinical symptoms attributable to moyamoya syndrome; the incidence of leukemia in Down syndrome is 10- to 20-fold that in the general population.58,59 Both patients received systemic and intrathecal chemotherapy as part of their treatment protocol, and 1 patient received a course of cranial radiotherapy. How these clinical associations independently affect the risk for developing moyamoya syndrome among children with Down syndrome is unknown. However, given the risk of significant strokes among patients with moyamoya syndrome, coupled with the effectiveness of treatment if it is instituted before debilitating strokes occur, we suggest that prophylactic screening of patients with Down syndrome for moyamoya syndrome with MRI/MRA may be useful. A similar strategy to screen for moyamoya syndrome among patients with sickle cell disease has been advocated by some. Additional study of the cost-effectiveness of this strategy may be warranted.

Previous data from our institution1 support the practice of treating patients with moyamoya syndrome as soon as possible. Timelines of patient strokes document that moyamoya syndrome is a progressive disease with cumulative morbidity and that this progression can be arrested with surgical treatment.1 The patients do require long-term aspirin therapy postoperatively. Although information regarding the potential complications of long-term aspirin therapy in this patient population is limited, a recent study comparing the use of aspirin versus warfarin among adult patients with intracranial arterial stenosis suggests that the long-term use of aspirin is relatively safe.60


   CONCLUSIONS
TOP
 ABSTRACT
 METHODS
 RESULTS
 DISCUSSION
 CONCLUSIONS
REFERENCES
 
Moyamoya syndrome in association with Down syndrome causes progressive neurologic disability resulting from cerebral infarction. The presence of moyamoya syndrome should be considered in the evaluation of patients with Down syndrome who present with transient ischemic attack-like symptoms. The clinical course and radiologic features of the moyamoya syndrome seen among these patients seem to mirror those of idiopathic moyamoya disease, and the patients with Down syndrome respond well to cerebral revascularization procedures such as pial synangiosis, just as the general population with moyamoya syndrome does. After surgery, additional strokes do not occur, and good functional outcomes can be anticipated for >50% of surgically treated patients. Given the treatable nature of this disease and its potentially severe consequences, we support the prophylactic screening of patients with Down syndrome for moyamoya syndrome with MRI/MRA.


   FOOTNOTES
 
Accepted May 11, 2005.

Address correspondence to R. Michael Scott, MD, Department of Neurosurgery, Children’s Hospital Boston, 300 Longwood Ave, Boston, MA 02115. E-mail: michael.scott{at}childrens.harvard.edu

No conflict of interest declared.


   REFERENCES
TOP
 ABSTRACT
 METHODS
 RESULTS
 DISCUSSION
 CONCLUSIONS
 REFERENCES
 

  1. Scott RM, Smith JL, Robertson RL, Madsen JR, Soriano SG, Rockoff MA. Long-term outcome in children with moyamoya syndrome after cranial revascularization by pial syangiosis. J Neurosurg. 2004;100 :142 –149[ISI][Medline]
  2. Matsushima Y, Inaha Y. Moyamoya disease in children and its surgical treatment: the introduction of a new surgical procedure and its follow-up angiograms. Childs Brain. 1984;11 :155 –170[ISI][Medline]
  3. Adelson PD, Scott RM. Pial synangiosis for moyamoya syndrome in children. Pediatr Neurosurg. 1995;23 :26 –33[ISI][Medline]
  4. Takeuchi K, Shimizu K. Hypoplasia of the bilateral internal carotid arteries. Brain Nerve. 1957;9 :37 –43
  5. Suzuki J, Takaku A. Cerebrovascular "moyamoya" disease: a disease showing abnormal net-like vessels in base of brain. Arch Neurol. 1969;20 :288 –299[ISI][Medline]
  6. Matsushima T, Inoue T, Natori Y. Children with unilateral occlusion or stenosis of the ICA associated with surrounding moyamoya vessels: "unilateral" moyamoya disease. Acta Neurochir (Wien). 1994;131 :196 –202[CrossRef][Medline]
  7. Olds MV, Griebel RW, Hoffman HJ, Craven M, Chuang S, Schutz H. The surgical treatment of childhood moyamoya disease. J Neurosurg. 1987;66 :675 –680[Medline]
  8. Arevalo CE, Marchezzotti A, Haessler A, Lanosa R. Moyamoya disease and Down syndrome [in Spanish]. Medicina (B Aires). 1993;53 :473
  9. Aylett SE, Britton JA, De Sousa CM. Down syndrome and moyamoya disease: presentation with subarachnoid hemorrhage. Pediatr Neurol. 1996;14 :259 –261[CrossRef][ISI][Medline]
  10. Berg JM, Armstrong D. On the association of moyamoya disease with Down syndrome. J Ment Defic Res. 1991;35 :398 –403
  11. Bitzer M, Topka H. Progressive cerebral occlusive disease after radiation therapy. Stroke. 1995;26 :131 –136[Abstract/Free Full Text]
  12. Cornelio-Nieto JO, Davila-Gutierrez G, Ferreyro-Irigoyen R, Alcala H. Acute hemiplegia in childhood and alternating hemiconvulsions secondary to moya-moya disease: report of a case associated with Down’s syndrome [in Spanish]. Bol Med Hosp Infant Mex. 1990;47 :39 –42[Medline]
  13. Cramer SC, Robertson RL, Dooling EC, Scott RM. Moyamoya and Down syndrome: clinical and radiological features. Stroke. 1996;27 :2131 –2135[Abstract/Free Full Text]
  14. Dai AI, Shaikh ZA, Cohen ME. Early-onset moyamoya syndrome in a patient with Down syndrome: case report and review of the literature. J Child Neurol. 2000;15 :696 –699[Abstract/Free Full Text]
  15. de Borchgrave V, Saussu F, Depre A, de Barsy T. Moyamoya disease and Down syndrome: case report and review of the literature. Acta Neurol Belg. 2002;102 :63 –66[Medline]
  16. Fukushima Y, Kondo Y, Kuroki Y. Are Down syndrome patients predisposed to moyamoya disease? Eur J Pediatr. 1986;144 :516 –517[CrossRef][ISI][Medline]
  17. Fukuyama Y, Osawa M, Kanai N. Moyamoya disease (syndrome) and the Down syndrome. Brain Dev. 1992;14 :254 –256[ISI][Medline]
  18. Fung CW, Kwong KL, Tsui EY, Wong SN. Moyamoya syndrome in a child with Down syndrome. Hong Kong Med J. 2003;9 :63 –66[Medline]
  19. Gaggero R, Donati PT, Curia R, De Negri M. Occlusion of unilateral carotid artery in Down syndrome. Brain Dev. 1996;18 :81 –83[CrossRef][ISI][Medline]
  20. Goldstein EM, Singer HM. Moyamoya-like disease in Down’s syndrome. Pediatr Neurosurg. 1990-1991;16 :14 –16[ISI][Medline]
  21. Gordon N, Isler W. Childhood moyamoya disease. Dev Med Child Neurol. 1989;31 :103 –107[ISI][Medline]
  22. Ichiba N, Murakawa S, Ohtahara S. A case of Down syndrome with "moyamoya" disease: a consideration on fibromuscular dysplasia [in Japanese]. No To Hattatsu. 1984;16 :487 –491[Medline]
  23. Inoue R, Katayama S, Kasai N, Hori S. Middle cerebral artery occlusion with unilateral moyamoya like vessels and with ruptured anterior cerebral artery aneurysm: its relationship to the antiphospholipid syndrome [in Japanese]. No To Shinkei. 1994;46 :995 –998[Medline]
  24. Inoue T, Matsushima T, Fujii K, Fukui M, Hasuo K, Matsuo H. Akin moyamoya disease in children [in Japanese]. No Shinkei Geka. 1993;21 :59 –65[Medline]
  25. Junqueira PA, Moura-Ribeiro MV. Moyamoya and Down syndrome: study conducted by meta-analysis [in Portuguese]. Arq Neuropsiquiatr. 2002;60 :274 –280[Medline]
  26. Kestle J, Hoffman H, Mock A. Moyamoya phenomenon after radiation for optic glioma. J Neurosurg. 1993;72 :32 –35
  27. Kitahara T, Okumura K, Semba A, Yamaura A, Makino H. Genetic and immunologic analysis on moya-moya. J Neurol Neurosurg Psychiatry. 1982;45 :1048 –1052[Abstract]
  28. Kushima K, Satoh Y, Ban Y, et al. Graves thyrotoxicosis and moyamoya disease. Can J Neurol Sci. 1991;18 :140 –142[ISI][Medline]
  29. Leno C, Mateo I, Cid C, Berciano J, Sedano C. Autoimmunity in Down syndrome: another possible mechanism of moyamoya disease. Stroke. 1998;29 :868 –869[Free Full Text]
  30. Mito T, Becker LE. Vascular dysplasia in Down syndrome: a possible relationship to moyamoya disease. Brain Dev. 1992;14 :248 –251[Medline]
  31. Nagaska T, Shiozawa Z, Kobayashi M, Shindo K, Tsunoda S, Amino A. Autopsy findings in Down syndrome with cerebrovascular disorder. Clin Neuropathol. 1996;15 :145 –149[ISI][Medline]
  32. Nishimura M, Takakura H, Ieshima A, Eda I, Ohno K, Takashima S. A case of Down syndrome with moyamoya disease [in Japanese]. No To Hattatsu. 1985;17 :71 –75[Medline]
  33. Okuno T, Prensky A, Gado M. The moyamoya syndrome association with irradiation of an optic glioma in children: report of two cases and review of the literature. Pediatr Neurol. 1985;1 :311 –316[CrossRef][Medline]
  34. Outwater EK, Platenberg RC, Wolpert SM. Moyamoya disease in Down syndrome. AJNR Am J Neuroradiol. 1989;10(suppl) :S23 –S24
  35. Park M, Raila FA, Russell WF. Moyamoya disease in an adult with Down syndrome: comparison of magnetic resonance angiography and conventional angiography. South Med J. 1996;89 :89 –92[ISI][Medline]
  36. Pearson E, Lenn NJ, Cail WS. Moyamoya and other causes of stroke in patients with Down syndrome. Pediatr Neurol. 1985;1 :174 –179[CrossRef][Medline]
  37. Rajakulasingam K, Cerullo L, Raimondi A. Childhood moyamoya syndrome: postirradiation pathogenesis. Childs Brain. 1975;5 :467 –475
  38. Schulz IS, Jahara F, Pompeu F, Figueira F, de Oliveira MI. Progressive occlusive disease of the cerebral arteries associated with Down syndrome: considerations on the etiopathogenesis [in Portuguese]. Arq Neuropsiquiatr. 1981;39 :237 –243[Medline]
  39. Soto-Ares G, Hamon-Kerautret M, Leclerc X, Vallee L, Pruvo JP. Moyamoya associated with Down syndrome. J Radiol. 1996;77 :441 –444[Medline]
  40. Suzuki J. Moyamoya Disease. New York, NY: Springer; 1983:131–143
  41. Takanashi J, Sugita K, Honda A, Niimi H. Moyamoya syndrome in a patient with Down syndrome presenting with chorea. Pediatr Neurol. 1993;9 :396 –398[CrossRef][ISI][Medline]
  42. Takanashi J, Sugita K, Ishii M. A girl with Down syndrome complicated by moyamoya disease and symptomatic atlanto-axial instability [in Japanese]. No To Hattatsu. 1993;25 :248 –252[Medline]
  43. Takasugi H, Maemoto T, Kitazawa K, Honda A. A case of Down syndrome with moyamoya syndrome presenting extensive multiple cerebral infarction during measles infection [in Japanese]. No To Hattatsu. 2000;32 :39 –43[Medline]
  44. van Erven PM, Gabreels FJ, Thijssen HO, Renier WO. The moya-moya syndrome: a report of two children. Clin Neurol Neurosurg. 1982;84 :179 –184[CrossRef][ISI][Medline]
  45. Vicari S, Albertini G. Moyamoya disease in Down syndrome: a report of two cases. J Ment Defic Res. 1991;35 :392 –397
  46. Wanifuchi H, Kagawa M, Takeshita M, et al. Autoimmune antibody in moyamoya disease [in Japanese]. No Shinkei Geka. 1986;14 :31 –35[Medline]
  47. Matsushima Y, Aoyagi M, Niimi Y, et al. Symptoms and their pattern of progression in childhood moyamoya disease. Brain Dev. 1990;12 :784 –789[Medline]
  48. Gordon N. Alternating hemiplegia of childhood. Dev Med Child Neurol. 1995;37 :464 –468[Medline]
  49. Ohaegbulam C, Magge S, Scott RM. Moyamoya syndrome. In: McLone DG, ed. Pediatric Neurosurgery: Surgery of the Developing Nervous System. New York, NY: WB Saunders; 2001:1077–1092
  50. Imaizumi F, Hayashi K, Saito K, Osawa M, Fukuyama Y. Long-term outcomes of pediatric moyamoya disease monitored to adulthood. Pediatr Neurol. 1998;18 :321 –325[Medline]
  51. Yonekawa Y, Goto Y, Ogata N. Moyamoya disease: diagnosis, treatment, and recent achievement. In: Barnett HJM, Mohr JP, Stein BM, Yatsu FM, eds. Stroke: Pathophysiology, Diagnosis, and Management. New York, NY: Churchill Livingstone; 1992:721–748
  52. Nishimoto A. Moyamoya disease. Neurol Med Chir. 1979;19 :221 –228
  53. Matsushima Y, Fukai N, Tanaka K. A new surgical treatment of moyamoya disease in children: a preliminary report. Surg Neurol. 1981;15 :313[CrossRef][Medline]
  54. Moritake K, Handa H, Yonekawa Y, Taki W, Okuno T. Follow-up study on the relationship between age at onset of illness and outcome in patients with "moyamoya disease." Neurol Surg. 1986;14 :957 –963
  55. Gadoth N. On the problem of essential and secondary moyamoya and vascular dysplasia in Down syndrome. Brain Dev. 1993;15 :317 –318[Medline]
  56. Jansen JN, Donker AJ, Luth WJ, Smit LM. Moyamoya disease associated with renovascular hypertension. Neuropediatrics. 1990;21 :44 –47[Medline]
  57. Gururaj A, Hardy D, Al-Gazali LI, Sztriha L, Roos A, Nork M. Are the strokes in moyamoya syndrome associated with Down syndrome due to protein C deficiency? Brain Dev. 2002;24 :719 –722[Medline]
  58. Fong CT, Brodeur GM. Down’s syndrome and leukemia: epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis. Cancer Genet Cytogenet. 1987;28 :55 –76[CrossRef][ISI][Medline]
  59. Zipursky A, Poon A, Doyle J. Leukemia in Down syndrome: a review. Pediatr Hematol Oncol. 1992;9 :139 –149[ISI][Medline]
  60. Chimowitz MI, Lynn MJ, Howlett-Smith H, et al. Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis. N Engl J Med. 2005;352 :1305 –1316[Abstract/Free Full Text]
PEDIATRICS (ISSN 1098-4275). ©2005 by the American Academy of Pediatrics



This article has been cited by other articles:


Home page
 StrokeHome page
E. S. Roach, M. R. Golomb, R. Adams, J. Biller, S. Daniels, G. deVeber, D. Ferriero, B. V. Jones, F. J. Kirkham, R. M. Scott, et al.
Management of Stroke in Infants and Children: A Scientific Statement From a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young
Stroke, September 1, 2008; 39(9): 2644 - 2691.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jea, A.
Right arrow Articles by Scott, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jea, A.
Right arrow Articles by Scott, R. M.
Related Collections
Right arrow Surgery