TABLE 3. Scores on the CTRS-L for Active Treatment and Placebo-Crossover Groups at Pretreatment Baseline, 3 Months, and 6 Months (Age Standardized With Respect to General Population Normative Values, in the Form of
t Scores: Mean: 50; SD: 10)
|
Mean Score (SD)
|
0- to 3-mo Group Comparisons, Mann-Whitney 2-Tailed Test
|
Mean Score (SD), 6 mo
|
Baseline
|
3 mo
|
Z |
P |
Active LOCF (n = 2) |
Crossover LOCF (n = 3) |
| Active (n = 50) |
Placebo (n = 52) |
Active LOCF (n = 6) |
Placebo LOCF (n = 7) |
|
| Subscales |
|
|
|
|
|
|
|
|
| Opposition |
59.5 (13.0) |
59.2 (13.6) |
56.2 (12.2) |
59.7 (13.8) |
2.42 |
<.02 |
54.9 (13.1) |
56.6 (13.5) |
| Cognitive problems |
65.9 (9.2) |
63.9 (9.8) |
61.2 (10.0) |
63.0 (10.3) |
4.13 |
<.0001 |
59.4 (10.4) |
60.4 (10.1) |
| Hyperactivity |
61.9 (12.7) |
61.0 (13.5) |
57.3 (11.8) |
61.3 (12.6) |
5.08 |
<.00001 |
55.5 (11.0) |
58.2 (13.3) |
| Anxious/shy |
62.8 (12.1) |
61.3 (13.9) |
59.3 (10.3) |
61.3 (13.1) |
3.03 |
<.002 |
56.5 (10.8) |
56.9 (12.8) |
| Perfectionism |
53.6 (9.8) |
51.8 (9.0) |
52.4 (9.1) |
52.0 (9.8) |
1.37 |
.2 |
52.4 (9.8) |
50.3 (9.6) |
| Social problems |
56.8 (12.9) |
58.1 (11.9) |
54.9 (11.2) |
57.8 (11.4) |
1.72 |
<.09 |
53.9 (11.1) |
55.6 (10.9) |
| Global scales |
|
|
|
|
|
|
|
|
| Conners' index |
66.2 (10.7) |
64.0 (12.0) |
59.9 (10.6) |
63.8 (12.1) |
5.78 |
<.00001 |
58.3 (11.6) |
61.1 (13.5) |
| Conners' global restless-impulsive |
66.3 (10.7) |
64.2 (12.2) |
60.4 (11.0) |
64.3 (11.9) |
5.56 |
<.00001 |
58.0 (11.9) |
61.5 (13.9) |
| Conners' global emotional lability |
61.7 (15.2) |
59.1 (12.2) |
58.5 (14.1) |
59.9 (13.1) |
2.34 |
<.02 |
55.4 (13.7) |
54.8 (11.4) |
| Conners' global index |
66.9 (12.2) |
64.1 (12.5) |
60.8 (11.9) |
64.4 (12.9) |
5.62 |
<.00001 |
58.1 (12.8) |
60.7 (13.8) |
| DSM-IV inattention |
65.2 (9.9) |
64.3 (9.8) |
60.1 (10.2) |
62.7 (10.1) |
3.92 |
<.0001 |
57.9 (11.1) |
59.5 (11.3) |
| DSM-IV hyperactivity |
61.1 (13.0) |
60.4 (13.9) |
57.1 (12.6) |
60.2 (13.9) |
4.87 |
<.00001 |
55.7 (12.3) |
58.0 (13.8) |
| DSM-IV Total ADHD |
64.6 (10.9) |
63.7 (11.5) |
59.5 (10.8) |
62.7 (11.9) |
5.00 |
<.00001 |
57.5 (11.6) |
59.6 (12.7) |
|
The CTRS-L20 consists of 59 items describing different aspects of child behavior, each endorsed with a 4-point scale. Item scores are combined in different ways to yield raw scores for the 6 subscales and 7 global scales shown, each of which then yields an age-standardized score for comparability with general population normative values. Because analyses were conducted on an intent-to-treat basis, the total number of participants (n) remained constant throughout the duration of the study, but data for children who had dropped out at each time point were imputed as the last observation carried forward (LOCF), and their numbers are shown.
