TABLE 2. Reading and Spelling Ages for Active Treatment and Placebo-Crossover Groups at Pretreatment Baseline, 3 Months, and 6 Months
|
Mean Age (SD)
|
0- to 3-mo Group Comparisons, Mann-Whitney 2-Tailed Test
|
Mean Age (SD), 6 mo
|
Baseline
|
3 mo
|
Z |
P |
Active LOCF (n = 4) |
Crossover LOCF (n = 7) |
| Active (n = 55) |
Placebo (n = 57) |
Active LOCF (n = 0) |
Placebo LOCF (n = 2) |
|
| Reading age |
93.6 (18.6) |
99.8 (25.5) |
103.2 (28.4) |
103.2 (27.1) |
2.87 |
<.004 |
114.0 (34.1) |
116.0 (34.1) |
| Spelling age |
92.2 (16.3) |
95.5 (17.6) |
98.8 (22.0) |
96.7 (17.9) |
3.36 |
<.001 |
104.1 (25.0) |
102.8 (22.2) |
|
Reading and spelling ages indicate the level of achievement that would be expected by a normal child of a given chronologic age. These scores were derived from single-word reading and spelling tests from the Wechsler Objective Reading Dimensions19 battery. Because analyses were conducted on an intent-to-treat basis, the total number of participants (n) remained constant throughout the duration of the study, but data for children who had dropped out at each time point were imputed as the last observation carried forward (LOCF), and their numbers are shown.
