TABLE 1. Movement Assessment Battery for Children (Motor Skills) for Active Treatment and Placebo-Crossover Groups at Pretreatment Baseline, 3 Months, and 6 Months
|
Mean Score (SD)
|
0- to 3-mo Group Comparisons, Mann-Whitney 2-Tailed Test
|
Mean Score (SD), 6 mo
|
Baseline
|
3 mo
|
Z |
P |
Active LOCF (n = 10) |
Crossover LOCF (n = 7) |
| Active (n = 60) |
Placebo (n = 57) |
Active LOCF (n = 5) |
Placebo LOCF (n = 2) |
|
| Manual dexterity |
10.0 (2.5) |
9.6 (1.9) |
8.7 (2.8) |
8.7 (1.9) |
0.96 |
.4 |
7.4 (2.3) |
7.6 (2.1) |
| Ball skills |
2.1 (2.5) |
2.5 (2.8) |
1.7 (2.3) |
1.6 (2.2) |
0.57 |
.6 |
1.1 (1.8) |
1.1 (1.8) |
| Static and dynamic balance |
3.5 (3.6) |
3.1 (2.7) |
2.5 (3.3) |
1.8 (2.5) |
1.03 |
.3 |
1.9 (2.8) |
1.3 (2.2) |
| Total impairment |
15.6 (5.7) |
15.2 (5.0) |
13.1 (5.9) |
12.1 (5.1) |
0.42 |
.7 |
10.4 (4.9) |
10.0 (5.0) |
| Percentile |
5.9 (4.6) |
5.8 (4.3) |
12.3 (11.2) |
12.9 (10.1) |
0.58 |
.6 |
19.5 (14.7) |
20.0 (12.6) |
|
The scores shown are derived from 8 different subtests of the Movement Assessment Battery for Children,18 which are grouped into 3 categories, manual dexterity (3 subtests), ball skills (2 subtests), and static and dynamic balance (3 subtests). Each subtest yields a crudely age-standardized impairment score, ranging from 0 (no impairment) to 5 (severe impairment). For the manual dexterity and static and dynamic balance categories, the maximal possible impairment score is 15; for ball skills, the maximal possible impairment score is 10. The total impairment score represents the sum of these 3 categories (maximum of 40). For any of these impairment scores, reductions correspond to improved performance. Percentile scores (relative to general population normative values) are derived from the total impairment scores, with higher percentiles representing better overall motor performance. Because analyses were conducted on an intent-to-treat basis, the total number of participants (n) remained constant throughout the duration of the study, but data for children who had dropped out at each time point were imputed as the last observation carried forward (LOCF), and their numbers are shown.
