ELECTRONIC ARTICLE |

* Center for Autism and Developmental Disabilities Epidemiology, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
Divisions of Epidemiology and Clinical Research, University of Minnesota, Minneapolis, Minnesota
| ABSTRACT |
|---|
|
|
|---|
Design. Comparison of birth cohort curves constructed from administrative data.
Setting and Population. US children 6 to 17 years of age between 1992 and 2001.
Main Outcome Measures. A disability category classification of autism, mental retardation, speech and language impairment, traumatic brain injury, or other health impairment, as documented by state departments of education and reported to the Office of Special Education Programs, US Department of Education.
Results. Prevalences of disability category classifications for annual birth cohorts from 1975 to 1995 were calculated by using denominators from US Census Bureau estimates. For the autism classification, there were birth cohort differences, with prevalences increasing among successive (younger) cohorts. The increases were greatest for annual cohorts born from 1987 to 1992. For cohorts born after 1992, the prevalence increased with each successive year but the increases did not appear to be as great, although there were fewer data points available within cohorts. No concomitant decreases in categories of mental retardation or speech/language impairment were seen. Curves for other health impairments, the category including children with attention-deficit/hyperactivity disorder, also showed strong cohort differences.
Conclusions. Cohort curves suggest that autism prevalence has been increasing with time, as evidenced by higher prevalences among younger birth cohorts. The narrowing in vertical separation of the cohort curves in recent years may mark a slowing in the autism prevalence increase.
Key Words: autism prevalence trends
Abbreviations: ASD, autism spectrum disorder OSEP, Office of Special Education Programs IDEA, Individuals with Disabilities Education Act ADHD, attention-deficit/hyperactivity disorder TBI, traumatic brain injury MADDSP, Metropolitan Atlanta Developmental Disabilities Surveillance Program
In recent years, concern has increased markedly about the magnitude and causes of the apparent increase in the prevalence of autism spectrum disorder (ASD) in the United States and other countries.1 Administrative data, ie, information collected for the purposes of program management, as opposed to scientific research, from several states have been cited in scientific reports2,3 and media stories.4,5 Although there are challenges in interpreting trends in administrative data, this information at least indicates the real public health burden, in that it reflects the numbers of individuals receiving services in a given setting. A national source of administrative data on children with ASD is the United States Department of Education, Office of Special Education Programs (OSEP). OSEP maintains standardized compilations of state counts of children receiving free, appropriate, public education services, classified into 13 primary disability categories defined under the Individuals with Disabilities Education Act (IDEA). One of these categories is autism. This brief report uses OSEP administrative data to assess secular trends in ASD prevalence among US school-aged children and to compare these trends with those for selected other IDEA disability categories.
| METHODS |
|---|
|
|
|---|
Prevalence estimates were stratified according to birth cohort and displayed visually as a plot of prevalence (ordinate) versus age (abscissa). The ordinate uses a logarithmic scale, and the vertical distance between curves represents the percentage change, not the absolute difference, in prevalence estimates. For example, a 25% increase in prevalence at age 10 between a younger birth cohort and an older birth cohort would be evident as the same vertical distance regardless of the baseline prevalence for the older birth cohort. Also, to ensure visual comparability among graphs, ordinates are scaled as 2 log-units in length. Separation of the cohort curves (with younger cohorts having higher age-specific prevalence) indicates an increase in prevalence with time. It should be noted that the use of the logarithmic scale, while making differences comparable in percentage change terms, understates absolute differences. We also include a table displaying the prevalence estimates, percentage changes, and absolute differences with time for 3 of the 5 classifications for which we created graphs.
| RESULTS |
|---|
|
|
|---|
|
|
Similarly, the curves for speech/language impairment indicate no cohort differences. The patterns with respect to age are as expected. At young ages, speech/language impairment prevalence is many times higher than that of autism; however, prevalence decreases dramatically from age 7 to age 17 years. The decrease in the prevalence of speech and language impairment is likely a result of children losing this disability category classification, which is expected to occur to a greater extent for this category (ie, in cases of articulation disorders and dysfluency that resolve with time), compared with the other categories.
The curves for other health impairments are notable for 2 reasons, ie, because this is the disability classification that typically includes children with attention-deficit/hyperactivity disorder (ADHD) and because there are strong cohort differences. Prevalence is higher for successive birth cohorts, with the greatest annual increases occurring between the 1980 and 1984 birth cohorts. Within cohorts, the prevalence of other health impairments increases sharply through 11 years of age, with the rate of increase gradually decreasing in successive years.
| DISCUSSION |
|---|
|
|
|---|
Because the autism classification was first introduced in 1992, some of the increase in prevalence should be attributable merely to local education agencies incorporating the new category into their special education classification practices. As mentioned, the TBI classification was introduced at the same time as the autism classification. Initial percentage increases observed for TBI were on the same order of magnitude as those for autism but these increases, which we can assume were largely introductory effects, had generally subsided by the mid-1990s (an exception being the increases in 2001, which likely represented a period effect, as noted above).
Prevalence trends for the mental retardation and speech/language categories have not increased over time. This is of particular interest because it has been speculated that children who in past years might have been classified in one or another of these categories are now being classified in the autism category and this "diagnostic shifting" could be responsible for prevalence increases. Because there was no indication of decreases in one or another of these categories concomitant with, and of similar magnitude to, increases in autism classification prevalence, these data do not support the hypothesis of diagnostic shifting.
Like autism, other health impairment classification prevalence has increased dramatically in successive birth cohorts during the past decade. In submitting count data to OSEP, several state departments of education commented that increases in other health impairment counts are being driven primarily by increasing numbers of children with ADHD.615 At least since 1991, when an OSEP policy memo was released clarifying the potential eligibility of children with ADHD under the other health impairment classification,28 increasing numbers of children in this category have an ADHD diagnosis. Like ASD, ADHD is a complex, behavior-based diagnosis. The diagnoses underlying other special education classifications are not always straightforward, but in most instances they can be made on the basis of documented impairment in functional domains more easily measured than those of social interaction and attentiveness. This observation is, of course, not empirical evidence supporting the hypothesis that the increases in ADHD and ASD prevalences are attributable to changing patterns in diagnosis and classification, rather than changes in the real risk of the conditions. However, there is value in noting the similarities in the patterns of the curves for the autism and other health impairments categories and the contrast between these categories and the other categories. Whether the narrowing in vertical separation of the cohort curves, beginning for other health impairments with the 1987 birth cohort and for autism only with the most recent cohorts, marks the waning of increases in prevalence remains to be seen. Recent data have generally continued to suggest ASD prevalence growth,29,30 with one exception. Lingham et al31 used administrative data on autism cases identified in east London in the year 2000 to predict expected numbers of cases according to birth cohort, correcting for underascertainment among younger children with a statistical model. The data suggested prevalence leveling beginning with the 1993 birth cohort.
The data presented here, although derived from the only available source for national prevalence estimates, do have several limitations. Numerators are incomplete because some US school-aged children with ASD and/or the other conditions considered here do not acquire special education classifications and/or are educated outside of public school. Because educational classifications are intended only to match individuals with the most appropriate service delivery approach available, administrative data are more susceptible to diagnosis/classification bias than are data from research studies incorporating rigorous case definitions and case-confirmation criteria. IDEA does provide a standard definition for each disability category, but individual states develop their own eligibility criteria. The IDEA definition for autism is general enough to encompass all ASDs, but state eligibility criteria and the way in which they are implemented can limit, for example, the extent to which higher-functioning children on the autism spectrum receive autism special education classifications.
Since 1997, federal law has allowed state and local education agencies to extend use of the less-specific disability category "developmental delay" to children as old as age 9 at their discretion (it was limited previously to children
5 years of age). Children in the cohort born in 1991 were the first to have turned 6 years of age after this change went into effect. It is possible that increasing proportions of children in younger cohorts who would have been classified previously as having autism as they transitioned out of preschool special education retain developmental delay classifications. This could explain the observed narrowing of the distance between autism cohort curves beginning with the 1992 cohort and could mean that, contrary to what was conjectured earlier about an increasing prevalence of autism classification at younger ages leading to a flattening of the trend at older ages, there may actually be more children receiving autism classifications at older ages. In this case, the newest cohort curves, between which the distance appeared to be decreasing, may actually separate more at older ages.
One final classification issue to consider is that children with multiple impairments still receive only 1 special education classification. There could be variations with time in the single category to which children with autism and another impairment are assigned. IDEA includes an explicit category called "multiple disabilities," which is intended for children whose combination of impairments creates educational needs that cannot be met in programs designed for 1 impairment alone. Examination of the data for this category showed no strong overall cohort effect (data not shown); however, there could be cohort effects in the extent to which the subgroup of children with autism are assigned to this category.
Finally, because estimates displayed here are for prevalence rather than incidence, the patterns seen are potentially a function of both incidence and duration. In these data, duration represents the period of time during which children retain their classification in a particular disability category. Some children who lose a classification retain the underlying disability, although such children no longer contribute to the observed prevalence of their original classification. This is likely a far less frequent occurrence for autism, mental retardation, and other health impairments, compared with speech/language impairment.
Most of the limitations discussed decrease the utility of the special education data for generating accurate estimates of absolute condition frequencies. Data from the Metropolitan Atlanta Developmental Disabilities Surveillance Program (MADDSP) indicated that, although 91% of the 6- to 10-year-old children with identified autism in 1996 received special education services, only 48% of those who received special education services had autism as a primary special education classification (K. Van Naarden-Braun, personal communication, August 2004). At the same time, virtually all of the age-eligible children with a special education classification of autism met the case-definition criteria for autism in the MADDSP.29 This indicates that, in general, autism prevalence estimates based on special education data alone will be underestimates.
The drastic increase in the prevalence of the autism classification presents a major challenge to the nations special education service systems and is one that has already triggered responses from federal, state, and local agencies.32 These trends also present an epidemiologic challenge, by raising the question of how much of this increase can be attributed to real changes in risk, as opposed to changes in diagnostic and classification practices. An alliance of 16 sites, some working with the cooperation of their states education departments, has been funded by the Centers for Disease Control and Prevention to develop public health surveillance approaches for ASD and other developmental disabilities.33 These approaches are being modeled largely on the MADDSP experience. It is hoped that this effort will establish a stronger national information base with which ASD prevalence trends can be monitored and other important epidemiologic questions about ASD can be addressed.
| ACKNOWLEDGMENTS |
|---|
We thank Angeline B. David for her assistance in formatting the figures.
| FOOTNOTES |
|---|
Reprint requests to (C.J.N.) Center for Autism and Developmental Disabilities Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Suite E6030, Baltimore, MD 21205. E-mail: cnewscha{at}jhsph.edu
No conflict of interest declared.
| REFERENCES |
|---|
|
|
|---|
This article has been cited by other articles:
![]() |
J. M Stachnik and C. Nunn-Thompson Use of Atypical Antipsychotics in the Treatment of Autistic Disorder Ann. Pharmacother., April 1, 2007; 41(4): 626 - 634. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. O. Atladottir, E. T. Parner, D. Schendel, S. Dalsgaard, P. H. Thomsen, and P. Thorsen Time Trends in Reported Diagnoses of Childhood Neuropsychiatric Disorders: A Danish Cohort Study Arch Pediatr Adolesc Med, February 1, 2007; 161(2): 193 - 198. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. J. Barbaresi, S. K. Katusic, and R. G. Voigt Autism: A Review of the State of the Science for Pediatric Primary Health Care Clinicians. Arch Pediatr Adolesc Med, November 1, 2006; 160(11): 1167 - 1175. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. G. Gurney, M. L. McPheeters, and M. M. Davis Parental Report of Health Conditions and Health Care Use Among Children With and Without Autism: National Survey of Children's Health Arch Pediatr Adolesc Med, August 1, 2006; 160(8): 825 - 830. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. M ElChaar, N. M Maisch, L. M G. Augusto, and H. J Wehring Efficacy and Safety of Naltrexone Use in Pediatric Patients with Autistic Disorder Ann. Pharmacother., June 1, 2006; 40(6): 1086 - 1095. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. R. Herbert Large Brains in Autism: The Challenge of Pervasive Abnormality Neuroscientist, October 1, 2005; 11(5): 417 - 440. [Abstract] [PDF] |
||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||