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PEDIATRICS Vol. 114 No. 1 July 2004, pp. e85-e90

ELECTRONIC ARTICLE

Effect of Dextromethorphan, Diphenhydramine, and Placebo on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents

Ian M. Paul, MD, MSc*,{ddagger}, Katharine E. Yoder§, Kathryn R. Crowell, MD*, Michele L. Shaffer, PhD{ddagger}, Heidi S. McMillan, MD*, Lisa C. Carlson, MD*, Deborah A. Dilworth, RN* and Cheston M. Berlin, Jr., MD*

* Department of Pediatrics, Division of General Pediatrics
{ddagger} Department of Health Evaluation Sciences
§ Pennsylvania State College of Medicine, Hershey, Pennsylvania


   ABSTRACT
TOP
 ABSTRACT
METHODS
 RESULTS
 DISCUSSION
 REFERENCES
 
Objectives. To determine whether the commonly used over-the-counter medications dextromethorphan and diphenhydramine are superior to placebo for the treatment of nocturnal cough and sleep difficulty associated with upper respiratory infections and to determine whether parents have improved sleep quality when their children receive the medications when compared with placebo.

Methods. Parents of 100 children with upper respiratory infections were questioned to assess the frequency, severity, and bothersome nature of the nocturnal cough. Their answers were recorded on 2 consecutive days, initially on the day of presentation, when no medication had been given the previous evening, and then again on the subsequent day, when either medication or placebo was given before bedtime. Sleep quality for both the child and the parent were also assessed for both nights.

Results. For the entire cohort, all outcomes were significantly improved on the second night of the study when either medication or placebo was given. However, neither diphenhydramine nor dextromethorphan produced a superior benefit when compared with placebo for any of the outcomes studied. Insomnia was reported more frequently in those who were given dextromethorphan, and drowsiness was reported more commonly in those who were given diphenhydramine.

Conclusions. Diphenhydramine and dextromethorphan are not superior to placebo in providing nocturnal symptom relief for children with cough and sleep difficulty as a result of an upper respiratory infection. Furthermore, the medications given to children do not result in improved quality of sleep for their parents when compared with placebo. Each clinician should consider these findings, the potential for adverse effects, and the individual and cumulative costs of the drugs before recommending them to families.

Key Words: cough • upper respiratory infection • dextromethorphan • diphenhydramine • placebo

Abbreviations: URI, upper respiratory tract infection • DM, dextromethorphan • OTC, over-the-counter • DPH, diphenhydramine • PL, placebo

Cough may be the most bothersome symptom for children with upper respiratory tract infections (URIs), and each year results in more ambulatory health care visits than any other symptom in the United States.1 The use of codeine or dextromethorphan (DM), the most common over-the-counter (OTC) antitussive, for treatment of cough is not supported by the American Academy of Pediatrics, largely because there is a lack of proven benefit and some potential for toxicity and overdose.2,3 Diphenhydramine (DPH), an OTC antihistamine, is also commonly administered for symptomatic relief in children with URIs.

Cough is particularly vexing at night because it often adversely affects sleep for both ill children and their parents with impact on subsequent daytime activities. Thus, giving their children medications that contain either DM or DPH before bed is often an attempt by parents to improve their own sleep and functioning during the subsequent day.

In this era when health care expenses continue to escalate, consumers spend billions of dollars per year on OTC medications for cough.4,5 The desire to give or take a medicine commonly outweighs the paucity of sound research on the effect of these drugs or the conditions that require them. Unfortunately, there are no clearly proven therapeutic alternatives.

Although 2 older subjective investigations found DM to be an effective antitussive medication for children with URIs,6,7 more recent studies have shown it to be no better than placebo (PL) in controlling acute cough.8–13 Objective assessments of DM in adults with URI also have had conflicting results.14–16 DPH is generally thought to be ineffective when compared with PL for the treatment of acute cough as a result of URIs,17–19 but some reports contradict this belief.20,21 DPH is widely accepted as an effective sedative.18,22–28 This antihistamine was found to be significantly more sedating than PL in children with the common cold.18

The current lack of clarity regarding symptomatic care in children with cough as a result of URIs has created an environment in which many pediatricians prescribe,29 many Internet sites recommend,30 and therefore many parents administer cough suppressants or antihistamines to relieve these symptoms.31 The objective of this trial was to determine whether DM or DPH administered to children with acute cough as a result of URIs subjectively improves nocturnal cough when compared with PL. The quality of sleep for both the child and the administering parent were also important outcomes of interest. It was hypothesized that parents would report a greater improvement in symptoms for those who received the active medications than those whose children received PL.


   METHODS
TOP
 ABSTRACT
 METHODS
RESULTS
 DISCUSSION
 REFERENCES
 
From June 2002 through May 2003, patients were recruited from 2 university-affiliated pediatric practices in the Hershey, Pennsylvania, vicinity on presentation for an acute-care visit. Eligible patients were 2 through 18 years of age with cough attributed to URIs. URIs were characterized by the presence of rhinorrhea and cough for ≤7 days’ duration. Other symptoms may have included but were not limited to congestion, fever, sore throat, myalgias, and headache. Patients were excluded when they had signs or symptoms of a more treatable disease (eg, asthma, pneumonia, laryngotracheobronchitis, sinusitis) or allergic rhinitis (sneezing, itchy and watery eyes). They also were ineligible when they had a history of reactive airway disease, asthma, chronic lung disease, or allergic rhinitis. Patients also were excluded when they had taken a medication that included an antihistamine or DM on the evening before enrollment or within 8 hours of bedtime on the day of enrollment. Concurrent use of drugs that are known to inhibit cytochrome P450 2D6, such as serotonin-selective reuptake inhibitors, was also a contraindication to enrollment. Children who had comorbid diagnoses of otitis media or streptococcal pharyngitis and were prescribed antibiotics were not excluded from the investigation. Patients were not excluded when analgesic medications such as acetaminophen or ibuprofen were administered on either night of the study.

Subjective parental assessments of cough and sleep difficulty were assessed after informed consent was obtained through questions using a 7-point Likert scale (Fig 1). Three trained study coordinators and the principal investigator were responsible for survey administration. The range of cough frequency ranged from "constant" (equal to 6 points) to "not at all" (equal to 0 points); questions related to impact on ability to sleep, severity of cough, and bothersome nature of the cough ranged from "extremely" (6 points) to "not at all" (0 points). In an effort to administer medication to a population that was likely to receive a therapeutic intervention by parents, minimum symptom severity criteria for enrollment were established. Only parents who answered at least "somewhat" (3 points) for a minimum of 2 of 3 questions related to nocturnal cough frequency, impact on the child’s sleep, and impact on parental sleep were eligible.


Figure 1
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  		Fig 1. Survey questions to assess nocturnal cough and sleep difficulty.

 
After stratification for age (2–5 years, 6–11 years, 12–18 years), each child was randomly assigned in a double-masked manner to receive DM (Benylin; Parke Davis, Morris Plains, NJ), DPH (Diphen AF; Morton Grove Pharmaceuticals, Morton Grove, IL), or PL (Simple syrup NF; Humco, Texarkana, TX). Dosage for DM was based on the label recommendations with children 2 to 5 years of age receiving 7.5 mg/dose, children 6 to 11 years of age receiving 15 mg/dose, and children aged 12 to 18 years of age receiving 30 mg/dose. DPH was dosed by weight at 1.25 mg/kg/dose (maximum 50 mg/dose) as described by a standard pediatric reference.32 The medications were distributed by the pharmacy in a brown paper bag to mask the investigators to the volume of medication. Parents were instructed to administer the medication 30 minutes before the child was to go to sleep. A second survey asking the same questions was then administered the following day to assess symptom severity for the night when treatment was given.

Sample size calculations indicated that a total of 105 subjects (35 in each treatment arm) would have 80% power to detect a 1-point difference between any 2 treatment groups based on a 2-sided Mann-Whitney test with {alpha} = .05. The principle outcome measure of interest was frequency of cough. Change in cough severity, the impact of the cough on sleep for both child and parent, and the bothersome nature of the cough for the child and the parent all were secondary outcome measures of importance.

As distributional assumptions were satisfied, outcome measures were treated as interval data, providing a modest increase in power. Treatment group comparisons were conducted by 1-way analysis of variance. Fisher exact tests were used to compare adverse reaction rates between treatments. The between-night change in individual outcomes and the combined symptom score were evaluated using paired t tests for the entire cohort. The study was approved by the Penn State Milton S. Hershey Medical Center’s Institutional Review Board.


   RESULTS
TOP
 ABSTRACT
 METHODS
 RESULTS
DISCUSSION
 REFERENCES
 
One hundred children with URIs were enrolled and completed the single-night study. The median age of the patients was 4.50 years (range: 2.00–16.50 years) with no significant difference between treatment groups (Table 1). Thirty-three patients received diphenhydramine, 33 received dextromethorphan, and 34 received placebo. Fifty-eight percent of the children were female. The children were ill an average of 4.21 ± 1.57 days before participation without significant differences between the assigned treatment. In addition, there were no differences between measures of symptom severity at baseline.


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  		TABLE 1. Demographics and Baseline Characteristics

 
Symptom scores were obtained for the night before enrollment when no medications were given and then compared with scores from the subsequent night when either medication or PL was given before bed (Table 2). All outcomes showed dramatic improvement. The scores for cough frequency, impact on child and parent sleep, "bothersome" nature of cough, and severity of cough all were scored significantly lower on the second night (P < .0001). The mean combined symptom score was reduced from 19.83 to 8.93 (95% confidence interval for reduction: 9.38–12.42; P < .0001).


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  		TABLE 2. Comparison Between First and Second Nights of the Study for the Entire Cohort (N = 100)

 
However, when separated by treatment group, no significant differences were found for any of the outcome measures when comparing the effects of DPH, DM, and PL (Fig 2). For cough frequency, those who received DPH and DM had a mean 1.97-point improvement as rated by their parents compared with a mean 2.24-point change for the better in those who received PL (P = .56). Parents did rate their child’s sleep quality as better for those who received DPH with a mean improvement of 2.64 points compared with 1.88 points for DM and 2.18 points for PL, but this result did not achieve statistical significance (P = .28). This trend did not have an impact on the quality of parental sleep as reflected by changes of 2.67 points for the DPH arm and 2.45 and 2.59 points for DM and PL, respectively (P = .85). In all treatment arms, parents believed that the cough was less bothersome to their children, with improvements of 2.45 points for those who took DPH, 1.91 points for those who got DM, and 1.97 points for those in the PL arm (P = .29). Parents also noted similar improvements in the severity of their child’s cough regardless of treatment: 2.06 points with DPH, 1.85 points with DM, and 1.88 points with PL (P = .70). When the results for these 5 outcomes were combined, there was no significant difference between treatments. The children in the DPH treatment group improved by an average of 11.79 points compared with 10.06 for DM and 10.85 for PL (P = .62).


Figure 2
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  		Fig 2. Comparison of the impact of DPH, DM, and PL on cough frequency (a), child’s sleep (b), parent’s sleep (c), cough "bothersome" to child (d), cough severity (e), and combined symptom score (f).

 
Adverse effects were limited in this investigation (Table 3). The most commonly reported reaction was hyperactivity, which was reported for 14 children (14%), but there was no significant difference between the treatment arms, including placebo. The only 2 adverse reactions that approached statistical significance were insomnia in the DM arm (P = .07) and drowsiness in the DPH group (P = .07). One patient in each of the DPH and DM arms subsequently received a diagnosis and treatment for bacterial pneumonia; 1 patient in the placebo arm was subsequently treated for bacterial sinusitis.


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  		TABLE 3. Adverse Reactions

 

   DISCUSSION
TOP
 ABSTRACT
 METHODS
 RESULTS
 DISCUSSION
REFERENCES
 
This investigation sought to determine whether 2 common OTC medications were superior to placebo for the treatment of nocturnal cough as a result of URI. Because sleep difficulty for children and their parents is also an important source of morbidity with a URI, the effect of the medications on these outcomes was also examined. Disappointing was that neither DM nor DPH was superior to PL for any of the outcomes studied in this trial. The medications failed to produce an improvement in the frequency, severity, or bothersome nature of the cough to a greater degree than PL. Important for parents, neither their child’s sleep nor their own sleep was significantly better when their child received medication compared with PL. For the cohort as a whole, however, it should be noted that there was a significant improvement for all symptoms over the previous night. This should reassure clinicians and parents that regardless of treatment, the natural history of a URI favors resolution of symptoms with time.

The questionnaire used in this study was designed in a manner that would be easily reproducible and takes into account the symptoms that generally cause parents to bring their children to medical attention with a URI. Because the severity of these complaints is subjectively assessed in clinical practice, objective criteria were not mandatory to determine the answers to these clinical questions, as has been stated previously.9,18

That noted, subjective reporting of cough by children and their parents has been shown to be imprecise.33–38 These studies, however, were performed on children with chronic cough, asthma, or cystic fibrosis as opposed to the acute cough that was evaluated in this study. In addition, in this investigation, each parent served as his or her own control, because their answers were compared with their own responses from the previous night. Another limitation of the study was that compliance with medication administration could not be guaranteed. The only assurance available was that by the parent during the follow-up telephone interview.

It is important to note that this study evaluated the effect of the medications versus placebo using 1 dose administered on a single evening. It is possible that an effect could have been demonstrated with DPH or DM if children were given either multiple doses throughout the day or repeated nocturnal doses for several consecutive evenings. Finally, a no-treatment arm was not included in this study. Eccles39 detailed the placebo effect in studies that evaluated antitussives that may have been present in the current investigation.

We were interested in performing this study because cough can be an extremely frustrating symptom for children, parents, and physicians. Cough is the most common acute cause for an ambulatory health care visit in the United States and the second most common reason for visits during childhood.1 Nocturnal cough can be particularly annoying because of its adverse impact on the ability of children and their parents to sleep. Schools and child care facilities often do not tolerate a significant cough, and therefore cough leads to missed school for children and/or missed work for parents. It is because of these factors that parents come to clinicians for assistance, seeking treatment for this common symptom. Despite the American Academy of Pediatrics policy statement,2 the desire to lessen the symptoms for children and ease the frustration of parents leads clinicians to recommend OTC treatments for cough such as antitussives and antihistamines.

Given the results of this investigation and the results of other related investigations,8,9 it is important to evaluate whether the OTC availability of these substances is benign. For example, whereas the efficacy of DM has been uncertain, its potential for toxicity has not. Described reactions and associations using standard doses include dystonia,40 anaphylaxis,41 and bullous mastocytosis.42 Accidental ingestions and overdoses are not uncommon,3,43 and dependence,44 psychosis,45 mania,46,47 hallucinations,48 ataxia,49,50 somnolence,50 insulin-dependent diabetes,51 and death52 have been reported from high doses, particularly when DM is combined with other OTC medications.53,54 DM is also a drug of abuse among adolescents.55–60

First-generation antihistamines—DPH in particular—have also been shown to have adverse effects. This class of medications is known to produce somnolence but occasionally causes restlessness, nervousness, and insomnia with therapeutic doses.61–63 Standard doses of DPH have also been associated with acute dystonia,64 impaired driving ability,65,66 and an increased risk of serious injury.67 Chronic ingestion and overdose have been linked to dependence,68 psychosis,62,69,70 cardiac dysrhythmias and a prolonged QT interval,62,71–74 rhabdomyolysis,75,76 seizures,62,70 and death.77,78

The desire to ease symptoms is strong for both parents and clinicians. This investigation supports the concept that URIs are self-limited illnesses that improve with time. It also questions whether common OTC medications have a place in the treatment of these illnesses for children. Each clinician should consider these findings, the potential for adverse effects, and the individual and cumulative costs of the drugs before recommending them to families.


   ACKNOWLEDGMENTS
 
This investigation was supported by funds from the Children’s Miracle Network. The study used the facility of the Pennsylvania State College of Medicine General Clinical Research Center, NIH C06 RR016499, M01 RR010732.

We acknowledge Susan LaTournous, RN, and Sarah Sturgis, RN, CRNP, for study coordination; Christine Arnold, RN, CRNP, Mark Baker, MD, Maryellen Gusic, MD, Mary Jo Hall, MD, Jennifer Hubbell, MD, Sarah Iriana, MD, Jason Lerner, MD, Benjamin Levi, MD, PhD, Jody Ross, MD, Alawia Suliman, MD, Denise Telford-Wren, DO, Mark Widome, MD, MPH, and Ana Maria Temple, MD, for patient recruitment; Rosemary Polomano, RN, PhD, and Marsha Haak, MSN, RN, for help with survey and data collection form design; the Investigational and Outpatient Pharmacies at the Hershey Medical Center for assistance with medication distribution; and Vernon Chinchilli, PhD, for statistical support.


   FOOTNOTES
 
Received for publication Nov 6, 2003; Accepted Jan 28, 2004.

Reprint requests to (I.M.P.) Pennsylvania State College of Medicine, Department of Pediatrics, H085, PO Box 850, Hershey, PA 17033-0850. E-mail: ipaul{at}psu.edu


   REFERENCES
TOP
 ABSTRACT
 METHODS
 RESULTS
 DISCUSSION
 REFERENCES
 

  1. Cherry DK, Woodwell DA. National ambulatory medical care survey: 2000 summary. Adv Data. 2002;328 :1 –32
  2. Use of codeine- and dextromethorphan-containing cough remedies in children. American Academy of Pediatrics. Committee on Drugs. Pediatrics. 1997;99 :918 –920[Abstract/Free Full Text]
  3. Litovitz T, Manoguerra A. Comparison of pediatric poisoning hazards: an analysis of 3.8 million exposure incidents. A report from the American Association of Poison Control Centers. Pediatrics. 1992;89 :999 –1006[Abstract/Free Full Text]
  4. Rosendahl I. Expense of physician care spurs OTC, self-care market. Drug Topics. 1988;132 :62 –63
  5. Morice AH. Epidemiology of cough. Pulm Pharmacol Ther. 2002;15 :253 –259[CrossRef][ISI][Medline]
  6. Gruber CM, Carter CH. A measure of the effectiveness of propoxyphene antitussives in children. Am J Med Sci. 1961;242 :443 –446[ISI][Medline]
  7. Carter CH. A clinical evaluation of the effectiveness of novrad and acetylsalicylic acid in children with cough. Am J Med Sci. 1963;245 :713 –717[ISI][Medline]
  8. Korppi M, Laurikainen K, Pietikainen M, Silvasti M. Antitussives in the treatment of acute transient cough in children. Acta Paediatr Scand. 1991;80 :969 –971[ISI][Medline]
  9. Taylor JA, Novack AH, Almquist JR, Rogers JE. Efficacy of cough suppressants in children. J Pediatr. 1993;122 :799 –802[ISI][Medline]
  10. Smith MB, Feldman W. Over-the-counter cold medications. A critical review of clinical trials between 1950 and 1991. JAMA. 1993;269 :2258 –2263[Abstract]
  11. Schroeder K, Fahey T. Over-the-counter medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev. 2001:CD001831
  12. Schroeder K, Fahey T. Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults. BMJ. 2002;324 :329 –331[Abstract/Free Full Text]
  13. Schroeder K, Fahey T. Should we advise parents to administer over the counter cough medicines for acute cough? Systematic review of randomised controlled trials. Arch Dis Child. 2002;86 :170 –175[Abstract/Free Full Text]
  14. Parvez L, Vaidya M, Sakhardande A, Subburaj S, Rajagopalan TG. Evaluation of antitussive agents in man. Pulm Pharmacol. 1996;9 :299 –308[CrossRef][ISI][Medline]
  15. Lee PCL, Jawad MS, Eccles R. Antitussive efficacy of dextromethorphan in cough associated with acute upper respiratory tract infection. J Pharm Pharmacol. 2000;52 :1137 –1142[CrossRef][ISI][Medline]
  16. Pavesi L, Subburaj S, Porter-Shaw K. Application and validation of a computerized cough acquisition system for objective monitoring of acute cough: a meta-analysis. Chest. 2001;120 :1121 –1128[Abstract/Free Full Text]
  17. West S, Brandon B, Stolley P, Rumrill R. A review of antihistamines and the common cold. Pediatrics. 1975;56 :100 –107[Abstract/Free Full Text]
  18. Hutton N, Wilson MH, Mellits ED, et al. Effectiveness of an antihistamine-decongestant combination for young children with the common cold: a randomized, controlled clinical trial. J Pediatr. 1991;118 :125 –130[CrossRef][ISI][Medline]
  19. Clemens CJ, Taylor JA, Almquist JR, Quinn HC, Mehta A, Naylor GS. Is an antihistamine-decongestant combination effective in temporarily relieving symptoms of the common cold in preschool children? J Pediatr. 1997;130 :463 –466[CrossRef][ISI][Medline]
  20. Jaffe GV, Grimshaw JJ. Benylin expectorant versus actifed expectorant in the treatment of acute cough. Br J Clin Pract. 1985;39 :238 –242[ISI][Medline]
  21. Curley FJ, Irwin RS, Pratter MR, et al. Cough and the common cold. Am Rev Respir Dis. 1988;138 :305 –311[ISI][Medline]
  22. Russo RM, Gururaj VJ, Allen JE. The effectiveness of diphenhydramine HCI in pediatric sleep disorders. J Clin Pharmacol. 1976;16 :284 –288[Abstract]
  23. Rickels K, Morris RJ, Newman H, Rosenfeld H, Schiller H, Weinstock R. Diphenhydramine in insomniac family practice patients: a double-blind study. J Clin Pharmacol. 1983;23 :234 –242[Abstract]
  24. Roth T, Roehrs T, Koshorek G, Sicklesteel J, Zorick F. Sedative effects of antihistamines. J Allergy Clin Immunol. 1987;80 :94 –98[ISI][Medline]
  25. Gengo F, Gabos C, Miller JK. The pharmacodynamics of diphenhydramine-induced drowsiness and changes in mental performance. Clin Pharmacol Ther. 1989;45 :15 –21[ISI][Medline]
  26. Roehrs T, Zwyghuizen-Doorenbos A, Roth T. Sedative effects and plasma concentrations following single doses of triazolam, diphenhydramine, ethanol and placebo. Sleep. 1993;16 :301 –305[ISI][Medline]
  27. Witek TJ Jr, Canestrari DA, Miller RD, Yang JY, Riker DK. Characterization of daytime sleepiness and psychomotor performance following H1 receptor antagonists. Ann Allergy Asthma Immunol. 1995;74 :419 –426[ISI][Medline]
  28. Saitou K, Kaneko Y, Sugimoto Y, Chen Z, Kamei C. Slow wave sleep-inducing effects of first generation H1-antagonists. Biol Pharm Bull. 1999;22 :1079 –1082[ISI][Medline]
  29. Gadomski AM, Rubin JD. Cough and cold medicine use in young children: a survey of Maryland pediatricians. Md Med J. 1993;42 :647 –650[Medline]
  30. Pandolfini C, Impicciatore P, Bonati M. Parents on the web: risks for quality management of cough in children. Pediatrics. 2000;105 (1). Available at: pediatrics.org/cgi/content/full/105/1/e1
  31. Kogan MD, Pappas G, Yu SM, Kotelchuck M. Over-the-counter medication use among US preschool-age children. JAMA. 1994;272 :1025 –1030[Abstract]
  32. Lee C, Nechyba C, Gunn VL. Drug doses. In: Gunn VL, Nechyba C, eds. The Harriet Lane Handbook. 16th ed. Philadelphia, PA: Mosby; 2002:571–890
  33. Archer LN, Simpson H. Night cough counts and diary card scores in asthma. Arch Dis Child. 1985;60 :473 –474[Abstract]
  34. Falconer A, Oldman C, Helms P. Poor agreement between reported and recorded nocturnal cough in asthma. Pediatr Pulmonol. 1993;15 :209 –211[ISI][Medline]
  35. Brooke AM, Lambert PC, Burton PR, Clarke C, Luyt DK, Simpson H. Night cough in a population-based sample of children: characteristics, relation to symptoms and associations with measures of asthma severity. Eur Respir J. 1996;9 :65 –71[Abstract]
  36. Dales RE, White J, Bhumgara C, McMullen E. Parental reporting of children’s’ coughing is biased. Eur J Epidemiol. 1997;13 :541 –545[CrossRef][ISI][Medline]
  37. Chang AB, Newman RG, Carlin JB, Phelan PD, Robertson CF. Subjective scoring of cough in children: parent-completed vs child-completed diary cards vs an objective method. Eur Respir J. 1998;11 :462 –466[Abstract]
  38. Hamutcu R, Francis J, Karakoc F, Bush A. Objective monitoring of cough in children with cystic fibrosis. Pediatr Pulmonol. 2002;34 :331 –335[CrossRef][ISI][Medline]
  39. Eccles R. The powerful placebo in cough studies? Pulm Pharmacol Ther. 2002;15 :303 –308[CrossRef][ISI][Medline]
  40. Graudins A, Fern RP. Acute dystonia in a child associated with therapeutic ingestion of a dextromethorphan containing cough and cold syrup. J Toxicol Clin Toxicol. 1996;34 :351 –352[ISI][Medline]
  41. Knowles SR, Weber E. Dextromethorphan anaphylaxis. J Allergy Clin Immunol. 1998;102 :316 –317[CrossRef][ISI][Medline]
  42. Cook J, Stith M, Sahn EE. Bullous mastocytosis in an infant associated with the use of a nonprescription cough suppressant. Pediatr Dermatol. 1996;13 :410 –414[ISI][Medline]
  43. Chien C, Marriott JL, Ashby K, Ozanne-Smith J. Unintentional ingestion of over the counter medications in children less than 5 years old. J Paediatr Child Health. 2003;39 :264 –269[CrossRef][ISI][Medline]
  44. Fleming PM. Dependence on dextromethorphan hydrobromide. Br Med J (Clin Res Ed). 1986;293 :597
  45. Dodds A, Revai E. Toxic psychosis due to dextromethorphan hydrobromide. Med J Aust 1967;2
  46. Walker J, Lakshmi N. Benylin (dextromethorphan) abuse and mania. BMJ. 1993;306 :896
  47. Polles A, Griffith JL. Dextromethorphan-induced mania. Psychosomatics. 1996;37 :71 –74[Free Full Text]
  48. Nairn SJ, Diaz JE. Cold-syrup induced movement disorder. Pediatr Emerg Care. 2001;17 :191 –192[CrossRef][ISI][Medline]
  49. Shaul WL, Wandell M, Robertson WO. Dextromethorphan toxicity: reversal by naloxone. Pediatrics. 1977;59 :117 –118[Abstract/Free Full Text]
  50. Katona B, Wason S. Dextromethorphan danger. N Engl J Med. 1986;314 :993[ISI][Medline]
  51. Konrad D, Sobetzko D, Schmitt B, Schoenle EJ. Insulin-dependent diabetes mellitus induced by the antitussive agent dextromethorphan. Diabetologia. 2000;43 :261 –262[CrossRef][ISI][Medline]
  52. Rammer L, Holmgren P, Sandler H. Fatal intoxication by dextromethorphan: a report on two cases. Forensic Sci Int. 1988;37 :233 –236[CrossRef][ISI][Medline]
  53. Gadomski A, Horton L. The need for rational therapeutics in the use of cough and cold medicine in infants. Pediatrics. 1992;89 :774 –776[Abstract/Free Full Text]
  54. Gunn VL, Taha SH, Liebelt EL, Serwint JR. Toxicity of over-the-counter cough and cold medications. Pediatrics. 2001;108 (3). Available at: pediatrics.org/cgi/content/full/108/3/e52
  55. McCarthy JP. Some less familiar drugs of abuse. Med J Aust. 1971;2 :1078 –1081[ISI][Medline]
  56. Murray S, Brewerton T. Abuse of over-the-counter dextromethorphan by teenagers. South Med J. 1993;86 :1151 –1153[CrossRef][ISI][Medline]
  57. Darboe MN, Keenan GR Jr, Richards TK. The abuse of dextromethorphan-based cough syrup: a pilot study of the community of Waynesboro, Pennsylvania. Adolescence. 1996;31 :633 –644[ISI][Medline]
  58. Cranston JW, Yoast R. Abuse of dextromethorphan. Arch Fam Med. 1999;8 :99 –100[Free Full Text]
  59. McFee RB, Mofenson HC, Caraccio TR. Dextromethorphan: another "ecstasy"? Arch Fam Med. 2000;9 :123[Free Full Text]
  60. Noonan WC, Miller WR, Feeney DM. Dextromethorphan abuse among youth. Arch Fam Med. 2000;9 :791 –792[Free Full Text]
  61. Michelson AL, Francis FC. Antihistaminic drugs. N Engl J Med. 1958;258 :994 –1000
  62. Radovanovic D, Meier PJ, Guirguis M, Lorent JP, Kupferschmidt H. Dose-dependent toxicity of diphenhydramine overdose. Hum Exp Toxicol. 2000;19 :489 –495[Abstract/Free Full Text]
  63. Simons FE, Simons KJ. The pharmacology and use of H1-receptor-antagonist drugs. N Engl J Med. 1994;330 :1663 –1670[Free Full Text]
  64. Lavenstein BL, Cantor FK. Acute dystonia. An unusual reaction to diphenhydramine. JAMA. 1976;236 :291[CrossRef][ISI][Medline]
  65. O’Hanlon JF, Ramaekers JG. Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989–94. Allergy. 1995;50 :234 –242[ISI][Medline]
  66. Weiler JM, Bloomfield JR, Woodworth GG, et al. Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator. Ann Intern Med. 2000;132 :354 –363[Abstract/Free Full Text]
  67. Finkle WD, Adams JL, Greenland S, Melmon KL. Increased risk of serious injury following an initial prescription for diphenhydramine. Ann Allergy Asthma Immunol. 2002;89 :244 –250[ISI][Medline]
  68. de Nesnera AP. Diphenhydramine dependence: a need for awareness. J Clin Psychiatry. 1996;57 :136 –137
  69. Jones J, Dougherty J, Cannon L. Diphenhydramine-induced toxic psychosis. Am J Emerg Med. 1986;4 :369 –371[CrossRef][ISI][Medline]
  70. Koppel C, Ibe K, Tenczer J. Clinical symptomatology of diphenhydramine overdose: an evaluation of 136 cases in 1982 to 1985. J Toxicol Clin Toxicol. 1987;25 :53 –70[ISI][Medline]
  71. Hestand HE, Teske DW. Diphenhydramine hydrochloride intoxication. J Pediatr. 1977;90 :1017 –1018[CrossRef][ISI][Medline]
  72. Clark RF, Vance MV. Massive diphenhydramine poisoning resulting in a wide-complex tachycardia: successful treatment with sodium bicarbonate. Ann Emerg Med. 1992;21 :318 –321[CrossRef][ISI][Medline]
  73. Zareba W, Moss AJ, Rosero SZ, Hajj-Ali R, Konecki J, Andrews M. Electrocardiographic findings in patients with diphenhydramine overdose. Am J Cardiol. 1997;80 :1168 –1173[CrossRef][ISI][Medline]
  74. Sharma AN, Hexdall AH, Chang EK, Nelson LS, Hoffman RS. Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate. Am J Emerg Med. 2003;21 :212 –215[CrossRef][ISI][Medline]
  75. Haas CE, Magram Y, Mishra A. Rhabdomyolysis and acute renal failure following an ethanol and diphenhydramine overdose. Ann Pharmacother. 2003;37 :538 –542[Abstract/Free Full Text]
  76. Emadian SM, Caravati EM, Herr RD. Rhabdomyolysis: a rare adverse effect of diphenhydramine overdose. Am J Emerg Med. 1996;14 :574 –576[CrossRef][ISI][Medline]
  77. Goetz CM, Lopez G, Dean BS, Krenzelok EP. Accidental childhood death from diphenhydramine overdosage. Am J Emerg Med. 1990;8 :321 –322[CrossRef][ISI][Medline]
  78. Baker AM, Johnson DG, Levisky JA, et al. Fatal diphenhydramine intoxication in infants. J Forensic Sci. 2003;48 :425 –428[ISI][Medline]
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