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Missed Insulin Meal Boluses and Elevated Hemoglobin A_1c Levels in Children Receiving Insulin Pump Therapy

From the Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado

	ABSTRACT

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Objective. To identify possible causes of suboptimal glycemic control (ascertained by hemoglobin A_1c [HbA_1c] level) in youths using insulin pump therapy.

Methods. Forty-eight youths who were receiving insulin pump therapy for 6 months, and who were using insulin pumps and blood glucose meters with data that could be downloaded at our facility, are included in this cross-sectional study. Possible causes of suboptimal glycemic control were evaluated by using 4 information sources: 1) insulin pump data downloads; 2) glucose meter data downloads; 3) patient/family questionnaire about insulin bolusing habits, eating habits, exercise, and blood glucose testing habits; and 4) a physician questionnaire. Physicians completed the questionnaire during the patient interview after reviewing the downloaded information and discussing these results with the patient/family.

Results. The mean (± standard deviation) age of participants was 15.3 (±3.0) years (range: 7–20 years), and the mean (± standard deviation) duration of type 1 diabetes and continuous subcutaneous insulin infusion was 8.2 (±4.0) and 1.9 (±1.0) years, respectively. Patients who missed <1 bolus per week had a mean (95% confidence interval) HbA_1c level of 8.0% (7.7, 8.3), whereas those who missed 1 mealtime boluses per week had a mean HbA_1c level (95% confidence interval) of 8.8% (8.6, 9.1). No significant relationships were found between HbA_1c levels in males and females, the amount of exercise per week, or bolusing before insulin pump disconnection for exercise. Although not significant, a trend was found for those who missed <1 bolus per week to perform more blood glucose tests per day and for those who bolused before a meal rather than after to have lower HbA_1c levels. Significant correlations were found between HbA_1c levels and the number of missed mealtime boluses per week (r = .414) and mean blood glucose levels (r = .70).

Conclusion. Missed mealtime insulin boluses seem to be the major cause of suboptimal glycemic control in youths with diabetes receiving continuous subcutaneous insulin infusion therapy.

Key Words: type 1 diabetes • insulin pump • children • hemoglobin A_1c • missed meal bolus • continuous subcutaneous insulin infusion • CSII

Abbreviations: DCCT, Diabetes Control and Complications Trial • CSII, continuous subcutaneous insulin infusion • HbA_1c, hemoglobin A_1c • CI, confidence interval • BMI, body mass index

Intensive diabetes management was shown in the Diabetes Control and Complications Trial (DCCT) to reduce the risk for the eye, kidney, and nerve complications of diabetes.¹ In the DCCT, the intensive management included 3 insulin injections per day or continuous subcutaneous insulin infusion (CSII) (insulin pump) therapy. The mean hemoglobin A_1c (HbA_1c) level of the intensively treated patients was 7.1% for adults¹ and 8.1% for adolescents.² In a previous report from a general pediatric diabetes clinic, 39% of children changing to insulin pump therapy showed improvement in HbA_1c levels (a decrease 0.5%), although 64% either showed improvement (of at least a 1.0% decrease of HbA_1c levels) or maintained a HbA_1c level <8%.³ Unfortunately, 20% showed a worsening of their HbA_1c level from a mean of 7.8% to 8.8%. The clinical impression was that missed insulin boluses were a major reason for worsening glycemic control, although insulin pump data downloads were not available to confirm the impression. The purpose of the current study was to identify possible causes of suboptimal glycemic control in youths using insulin pump therapy.

	METHODS

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The first 48 youths seen at our clinic who were using insulin pumps and glucose meters with data that could be downloaded were included in this study. All participants were receiving insulin pump therapy for at least 6 months before inclusion and had attended pump training classes. All had received training on counting carbohydrates for the calculation of mealtime insulin boluses and agreed to perform at least 4 blood glucose tests per day before initiating insulin pump therapy. In addition, all participants were using Medtronic MiniMed (Northridge, CA) insulin pumps, because this was the only type of pump with data that could be downloaded at our facility at the time. A variety of glucose meters were used in this study, all of which had data that could be downloaded at our facility. Before inclusion, participants were required to sign a consent/assent form and complete a questionnaire approved by the Colorado Multiple Institutional Review Board. Parents of youths <18 years of age also signed the consent form.

A questionnaire was developed to identify possible reasons for suboptimal glycemic control in youths using insulin pumps, including missed mealtime insulin boluses, timing of meal boluses in relation to meals, pump disconnection and bolus for exercise, and number of blood glucose tests performed per day. Participants were asked to answer as accurately and honestly as possible and were told that they would not be criticized for their responses. Younger children (12 years old) completed the questionnaire with the assistance of their parents, whereas older children were encouraged to complete the questionnaire on their own. Participants (and families) were questioned about their insulin bolus administration habits and parameters and frequency of home blood glucose monitoring. Pump data downloads used in this study were analyzed over the 4 weeks before the clinic visit. Physicians estimated boluses missed per week (from the downloads) after interviewing the participant, taking into account the sleeping and eating habits of each participant for the time period, and then reported the result as a 1-week average. Occasions on which a participant did not bolus because hypoglycemia was experienced at mealtime or no carbohydrate was consumed were not counted as a missed bolus. Blood glucose data downloads were analyzed for the 30 days before the clinic visit. Responses on the patient questionnaire pertaining to boluses missed per week and blood glucose tests done per day were compared with physician estimates based on the downloaded data and the patient interview.

The HbA_1c levels were determined by using the DCA 2000 Analyzer (Bayer Diagnostics, Elkhart, IN) with a nondiabetic range of 3.2% to 6.2%. This method of HbA_1c analysis has been shown to be accurate in our laboratory.⁴ HbA_1c level at the time of study inclusion was used for analyses.

Statistical analyses were performed by using Microsoft (Seattle, WA) Excel 2000 for Windows and analyzed later by using SAS/STAT, Version 8e (SAS Institute, Inc, Cary, NC) statistical package for Windows.

	RESULTS

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The mean age (± standard deviation) of the participants was 15.3 (±3.0) years (range: 7–20 years), with a mean duration of diabetes of 8.2 (±4.0) years and time of insulin pump usage of 1.9 (±1.0) years (Table 1). There were 23 females and 25 males, and all patients were non-Hispanic white. The mean (95% confidence interval [CI[) HbA_1c level at the time of study was 8.5% (8.3, 8.7), with little variation among genders or age groups (Table 1).

View larger version (12K): [in this window] [in a new window]   Fig 1. HbA1c levels correlated with the number of missed meal insulin boluses per day (r = .4).

The only factor found to correlate significantly with the HbA_1c level was the number of missed mealtime insulin boluses (r = .41; P = .003; Fig 1). The most frequently reported reason for missing boluses was "forgetting" (67%). Other participants admitted to a fear of hypoglycemia (6%) as the reason for missed boluses, as well as inconvenience of the pump location (2%) and being too busy (8%).

Participants reported performing a mean (95% CI) of 4.7 (4.1, 5.3) blood glucose tests per day, although meter printouts revealed a mean of 3.6 (3.0, 4.2) tests per day (P = .017). The frequency of blood glucose testing did not significantly correlate with HbA_1c levels in this study (P = .25). However, mean blood glucose levels did correlate with HbA_1c levels (r = .7; P < .0001).

	DISCUSSION

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This is the first report of using insulin pump data downloads to evaluate diabetes management in youths using insulin pumps. In this group of patients, downloading of insulin pump data revealed that the major cause of suboptimal glycemic control was missed meal insulin boluses. The only other factor that correlated with HbA_1c values was the mean blood glucose level. Exercise, insulin pump disconnection, number of blood glucose tests done per day, BMI, and gender did not correlate with HbA_1c levels. Although we focused on meal bolusing, it is likely that participants who missed meal boluses also missed boluses with snacks.

In the past, intermediate-acting insulins (neutral protamine Hagedorn or Lente) were used to provide some insulin activity to cover the noon meal or an afternoon snack. This was not ideal, because the peaks in activity seldom coincided with the postprandial glucose load; however, it was better than no short-acting insulin bolus to cover food. Recently, it became common for youths to use insulin pumps or insulin glargine (Lantus) as the source of their basal insulin. The resultant basal activity from either therapy is very flat, and there is no insulin coverage for food intake unless a short-acting insulin bolus is taken. The time of day when blood glucose levels are the highest is after food intake, which is generally 1 to 2 hours after eating; thus, there needs to be adequate insulin coverage for this time period. It is thus not surprising that missed mealtime insulin boluses, as described in this report, are the major cause of elevated HbA_1c levels in youths receiving insulin pump therapy. It is also likely that a major reason for the lower HbA_1c levels in adults compared with children (including in the DCCT) relates to the greater vigilance of adults in giving insulin boluses whenever food is eaten as well as fewer snacks generally consumed by adults.

Figure 2 represents a pump printout for a teenage male (seen after the completion of this study) with an HbA_1c level of 10.0% who had been using a pump for 4 years and previously had been more compliant and in better glycemic control. The deterioration of his glucose control and compliance in giving boluses was temporally related to serious emotional stress in the family. He stated that he had been missing 2 mealtime boluses per week, although after reviewing his logbook diary with him, he admitted to missing 7 meal boluses per week (the Xs in Fig 2 represent times he admitted to missing boluses). Similarly, there were 7 missed meal boluses in his other weekly downloads.

View larger version (17K): [in this window] [in a new window]   Fig 2. Computer download of MiniMed 508 insulin pump data. Blanks for boluses at the usual times of meals and the blood glucose records were reviewed with the patient/family. Missed mealtime boluses (represented by an X) were counted only if the patient and family agreed that a meal had likely been eaten and a bolus not administered. Blood glucose records were not entered into the logbook feature of the insulin pump. U indicates units of insulin administered.

The question of how to best choose youths who will succeed in CSII therapy remains. Youths who miss shots, do not have close parental support, have difficulty remembering other life responsibilities, or have certain medical problems (psychological problems, attention-deficit disorder, etc) are going to be less likely to do well on CSII therapy. We have often suggested to such youths that they delay pump therapy until they are older, possibly making the switch before beginning college (when they are more mature and likely to remember to bolus). Perhaps the best prepump "test" would be to treat youths with Lantus insulin as a basal insulin and Humalog or NovoLog insulin before food intake.⁵ Youths on this type of insulin regimen, who are fastidious about giving premeal, short-acting insulin, will generally have HbA_1c levels <8% and probably would be successful using insulin pump therapy.

Controlling or losing weight through inadequate or missed insulin boluses could have been a factor for some participants, although this was not addressed in our study. These unhealthy weight-control/disordered eating practices are not uncommon in the adolescent population. One study of 70 adolescent females and 73 adolescent males with the same mean age as the participants in this study (15.3 years) and a similar race/ethnicity did address this issue.⁶ Eighteen percent of the young women (12 of 66) reported either missing insulin doses (10.3%) or decreasing the amount of insulin taken (7.4%) to lose weight; only 1 male reported similar behaviors. Higher levels of weight dissatisfaction and disordered eating habits correlated with higher BMI values. In the present study, there was no correlation of missed insulin boluses with BMI values, and males and females had a similar incidence of missed boluses.

A patient-education book states that it was a "clinical impression" that missing 1 meal bolus per week resulted in a half-point rise in HbA_1c level over a 3-month period.⁷ The current data (Fig 1) show that 2 missed boluses resulted in a half-point rise, and 4 missed boluses per week resulted in a full-point rise in HbA_1c level. However, the current data were from objective pump data downloads, whereas the "clinical impression" was from patient self-reporting, shown here to be underestimated by 50%.

	CONCLUSIONS

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Missed mealtime insulin boluses represent a major reason for suboptimal glycemic control in some youths with type 1 diabetes receiving insulin pump therapy. Future studies should address the issue of how best to help youths who do use insulin pumps to remember to bolus and how to identify youths and families ready for insulin pump therapy and those who should delay or even reconsider starting an insulin pump.

	ACKNOWLEDGMENTS

 
This research was supported by grant M01 RR00069 from the General Clinical Research Centers Program, National Centers for Research Resources, National Institutes of Health (Bethesda, MD), and the Children’s Diabetes Foundation at Denver, (Denver, CO).

	FOOTNOTES

 
Received for publication Aug 14, 2003; Accepted Nov 6, 2003.

Address correspondence to H. Peter Chase, MD, 4200 E 9th Ave, B140, Denver, CO 80262. E-mail: peter.chase{at}uchsc.edu

	REFERENCES

TOP ABSTRACT METHODS RESULTS DISCUSSION CONCLUSIONS REFERENCES

 

1. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med.1993; 329 :977 –986[Abstract/Free Full Text]
2. Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial. Diabetes Control and Complications Trial Research Group. J Pediatr.1994; 125 :177 –188[CrossRef][ISI][Medline]
3. Maniatis AK, Klingensmith GJ, Slover RH, Mowry CJ, Chase HP. Continuous subcutaneous insulin infusion therapy for children and adolescents: an option for routine diabetes care. Pediatrics.2001; 107 :351 –356[Abstract/Free Full Text]
4. Chase HP, Lockspeiser T, Peery B, et al. The impact of the Diabetes Control and Complications Trial and Humalog insulin on glycohemoglobin levels and severe hypoglycemia in type 1 diabetes. Diabetes Care.2001; 24 :430 –434[Abstract/Free Full Text]
5. Dixon B, Chase HP, Fiallo-Scharer R, et al. The addition of insulin Glargine to lower hypoglycemic events and A_1c levels in children and adolescents with type 1 diabetes [abstract]. Diabetes Care.2003; 52(suppl 1) :A401
6. Neumark-Sztainer D, Patterson J, Mellin A, et al. Weight control practices and disordered eating behaviors among adolescent females and males with type 1 diabetes: associations with sociodemographics, weight concerns, familial factors, and metabolic outcomes. Diabetes Care.2002; 25 :1289 –1296[Abstract/Free Full Text]
7. Chase, HP. Understanding Diabetes. 10th ed. Denver, CO: SFI; 2002:281. Available at: www.uchsc.edu/misc/diabetes/ud10.html

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