Published online June 1, 2007
PEDIATRICS Vol. 119 No. 6 June 2007, pp. 1257-1258 (doi:10.1542/peds.2007-0830)
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LETTER TO THE EDITOR

Mycoplasma pneumoniae Encephalitis and Reactivation of Herpes Simplex Virus: In Reply

Ari Bitnun, MD, MSc
Division of Infectious Diseases
Department of Paediatrics

Jorina M. Elbers, MD
Daune MacGregor, MD
Division of Neurology
Department of Paediatrics

Raymond Tellier, MD, MSc
Susan E. Richardson, MD
Department of Paediatric Laboratory Medicine
Hospital for Sick Children and University of Toronto
Toronto, Ontario, Canada M5G 1X8

The first 20% of the full text of this article appears below.

We thank Dr Eisenhut for his interest in our prospective 12-year study of herpes simplex encephalitis in children.1 Because of the standardized comprehensive prospective microbiologic investigations performed on all children who were admitted to our institution with acute encephalitis, evidence of infection with >1 potential pathogen is often observed. This approach is very different from retrospective reviews of cases in which the final diagnosis is the point of entry into the study. In a recent review of our data, approximately one fourth of the cases showed evidence of infection (of variable strength) with ≥2 pathogens.2 In situations such as this, it is often not possible to determine with certainty which pathogen . . . [Full Text of this Article]