Published online February 1, 2007
PEDIATRICS Vol. 119 No. 2 February 2007, pp. 422-423 (doi:10.1542/peds.2006-1253)
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LETTER TO THE EDITOR

Hypothermia: A Neuroprotective Therapy for Neonatal Hypoxic-Ischemic Encephalopathy

Dominic J. Wilkinson, MBBS, MBioeth, BMedSci, FRACP
Dan Casalaz, MBBS, MPubHlth, FRACP
Andrew Watkins, MBBS, FRACP
Chad C. Andersen, MBBS, FRACP
Department of Paediatrics
Mercy Hospital for Women
Melbourne, Victoria 3084, Australia

Trevor Duke, MBBS, MD, FRACP
Centre for International Child Health
Department of Paediatrics
University of Melbourne
Parkville, Victoria 3052, Australia

The first 20% of the full text of this article appears below.

To the Editor.—

Recently, Blackmon et al1 reviewed the current evidence for the effectiveness and safety of hypothermia in newborns with hypoxic-ischemic encephalopathy (HIE). They urged caution in the interpretation of recently published randomized, controlled trials and argued that ongoing controlled trials of hypothermia should be completed. However, is it ethical for these trials to continue?

All 3 trials of mild systemic hypothermia for infants with HIE showed a substantial reduction in the . . . [Full Text of this Article]


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