Published online November 1, 2004
PEDIATRICS Vol. 114 No. 5 November 2004, pp. 1369 (doi:10.1542/peds.2004-1695)
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Rebound Seizures During Rewarming

Malcolm Battin, MBChB
Department of Paediatrics

Laura Bennet, PhD
Department of Physiology

Alistair J. Gunn, MBChB, PhD
Departments of Paediatrics and Physiology
Auckland University
Auckland 1020, New Zealand

The first 20% of the full text of this article appears below.

To the Editor.

Rewarming after cooling treatment for severe hypoxic-ischemic encephalopathy is potentially more complex than induction of cooling, because it might lead to destabilizing changes in neuronal activity. On an empirical basis, clinical studies of therapeutic hypothermia typically have rewarmed infants at no more than 0.5°C per hour.1,2 We report rebound seizure activity in 1 infant during rewarming from a 72-hour . . . [Full Text of this Article]