Carol Lynn Berseth, MD
Mead-Johnson Nutritionals
Evansville, IN 47721-0001
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Despite necrotizing enterocolitis (NEC) being a significant contributor to the mortality and morbidity associated with premature birth, no clinical variables have been found to definitively predict the onset of NEC.1,2 Hence, we were very interested to read the article by Cobb et al3 that attempts to correlate gastric residuals and feeding intolerance with a higher risk of NEC. Neonatologists in different regions of practice arbitrarily attribute different gastric aspirate volumes and colors as indicative of feeding intolerance and possible development of NEC. Mihatsch et al,4 for instance, investigated whether 2 mL of gastric residual volume (or
20% of a 100 mL/kg feeding total in <750-g infants) would have a significant effect in delaying the achievement of full feeds; they concluded that 2 mL failed to identify infants who were subsequently delayed in reaching full feedings. Others, including our own group,48 have used a volume of 50% of a total 3-hour bolus feed as a marker indicative of bowel pathology, but no studies have clearly substantiated this practice. In their retrospective case-control study, Cobb et al found that those infants who went on the develop NEC had maximal
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A. B. Kenton, C. J. Fernandes, C. L. Berseth, B. A. Cobb, W. A. Carlo, and N. Ambalavanan Gastric Residuals in Prediction of Necrotizing Enterocolitis in Very Low Birth Weight Infants Pediatrics, June 1, 2004; 113(6): 1848 - 1849. [Full Text] [PDF] |
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