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PEDIATRICS Vol. 113 No. 1 January 2004, pp. 170-171

Gelatin Allergy

Tetsuo Nakayama, MD
Takuji Kumagai, MD
Laboratory of Viral Infection Control Kitasato Institutes for Life Sciences Tokyo 108-8641, Japan
Pediatric Allergy and Infectious Diseases Society of Sapporo Sapporo 004-0013, Japan

The first 20% of the full text of this article appears below.

To the Editor.—

We feel relieved after reading the paper by Pool et al and the VAERS Team1 on the prevalence of gelatin allergy in the United States. They conducted a retrospective analysis after measles-mumps-rubella (MMR) vaccination. Among 26 cases of anaphylaxis, only 6 (27%) were positive for anti-gelatin IgE antibodies. The rate of anaphylactic reactions reported to the VAERS is 1.8 per 1 million doses, and no substantial increase in number of reported allergic events after MMR was observed since the introduction of gelatin-containing diptheria-tetanus-acellular pertussis vaccine (DTaP) in 1997. We reported that the cases of anaphylaxis or urticaria showed high positive rates of anti-gelatin IgE antibodies, and we speculated the causal relationship of the sensitization by gelatin-containing DTaP.2 Discontinuation of gelatin-containing DTaP reduced the incidence of anaphylaxis after 1999,3 and we have no report of anaphylaxis after vaccination with live virus vaccines containing hydrolyzed porcine gelatin in the last few years. Thus, we were solicitous for the incidence of anaphylaxis in the United States, but they reported that the incidence of gelatin allergy was lower than that observed in Japan.

. . . [Full Text of this Article]