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Immediate Allergic Reactions to Cephalosporins: Cross-Reactivity and Selective Responses

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Purpose of the Study. Beta lactams are the most common agents involved in allergic reactions to antibiotics. There appears to be less cross-reactivity between penicillin and the newer generation cephalosporins. These latter agents might be associated with specific immunologic responses that do not cross-react with penicillins or other cephalosporins. These investigators examined the scope of immunoglobulin E (IgE) responses to various cephalosporins and penicillins in children and adults with histories compatible with cephalosporin allergy.

Study Population. Six children and 24 adults who had experienced urticaria/angioedema or anaphylaxis after exposure to injectable cephalosporins were selected for study. Reactions had occurred 1 to 48 months before evaluation. All 6 children had reacted to ceftriaxone, and 5/6 . . . [Full Text of this Article]

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