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PEDIATRICS Vol. 110 No. 1 July 2002, pp. 195

Amoxicillin Dosage

Giorgio Longo, MD
Egidio Barbi, MD
Clinica Pediatrica
Istituto per l’Infanzia Burlo Garofalo
Trieste, 34100, Italy

The first 20% of the full text of this article appears below.

To the Editor.—

We have read the clinical practice guideline about the management of sinusitis published on the behalf of the American Academy of Pediatrics1 and we particularly appreciated it, not only for the efficacy, but especially for the scientific rigor.

Nevertheless, we were surprised by the prescription of amoxicillin at the usual dosage (45 mg/kg/day) in 2 divided doses. Amoxicillin should be prescribed, according to its pharmacokinetics, in 3 doses. The 2-dose schedule has proved to be equally effective in the eradication of group A Streptococcus in acute tonsillitis but the pharmacokinetics of antibiotics in the tonsils . . . [Full Text of this Article]