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PEDIATRICS Vol. 103 No. 5 May 1999, pp. 1079

Brain Hypothermia and QT Interval

The first 20% of the full text of this article appears below.

To the Editor.

When any new therapy is proposed, it is important to monitor for adverse events. Mild systemic hypothermia to 35.5°C by head cooling in term infants with hypoxic ischemic encephalopathy has recently been reported to be safe, and a multinational study with the power to evaluate efficacy is planned.1 We have continued pilot studies with lower systemic temperatures, aiming to keep the nasopharyngeal temperature below 34°C, which was a critical temperature for neuronal rescue after carotid artery occlusion in our studies in fetal sheep.2 Hypothermia is associated with recognized electrocardiography changes including sinus bradycardia, prolonged PR interval, prolonged QT interval . . . [Full Text of this Article]
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