PEDIATRICS Vol. 102 No. 6 December 1998, pp. 1497-1498
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To the Editor.
Are small for gestational age (SGA) preterm infants at
increased or reduced risk of neonatal death? Currently, it seems either answer will do! In two recent papers, Horbar et al1,2 concluded after an analysis using logistic regression that SGA infants
have a significantly reduced risk of dying (odds ratio [OR] 0.63, confidence interval [CI] 0.55-0.86). In both cases, a birth weight
(BW)-defined cohort was studied (501-1500 g). As a consequence of the
1500-g cutoff, well-grown babies 29 to 31 weeks old were excluded,
while numerous SGA infants with gestations >31 weeks were included
(about 15%). These, as well as other studies using BW-defined
cohorts,3 continue to add support to the widely held
belief that SGA infants mature more rapidly than appropriate for
gestational
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