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Right arrow Infectious Disease & Immunity

PEDIATRICS Vol. 102 No. 4 October 1998, pp. 977-978

EXPERIENCE AND REASON:
Disseminated North American Blastomycosis in an Adolescent Male: A Delay in Diagnosis

The first 20% of the full text of this article appears below.

North American blastomycosis in children and adolescents is not commonly encountered. It is caused by the dimorphic fungus, Blastomyces dermatitidis, and was originally described by Gilchrist in 18941 and 1896.2 The typical patient is a male between the ages of 30 to 50 years who has had significant exposure to the outdoors.3 The rare occurrence in children and adolescents and the varied spectrum of clinical involvement make infection with B dermatitidis a potential diagnostic challenge in this patient population. A recent retrospective review at a large children's hospital during the period 1983-1995 identified only 10 patients with the disease.4 It was also noted that the diagnosis of pulmonary blastomycosis is more difficult in children, with 4 of 5 patients requiring open-lung biopsy for diagnostic confirmation. We present a case of disseminated North American blastomycosis in an adolescent male whose diagnosis was delayed for 4 months from the onset of symptoms.

    CASE REPORT

A previously healthy 15-year-old African-American male presented on dermatologic consultation with chronic respiratory symptoms, left wrist pain, and verrucous skin lesions. His symptoms had begun 4 months before with fever to 40°C, cough, and rhinorrhea. Initial treatment consisted of a 10-day course of amoxicillin for a presumed upper respiratory infection, without improvement. A chest radiograph revealed a right middle lobe infiltrate, but despite a 10-day course of erythromycin, his cough persisted and he developed wheezing. In addition, he noted the onset of left wrist pain and subsequently developed a tender, erythematous, verrucous plaque over the area. On incision and drainage of this lesion, large amounts of purulent material were noted. He was again prescribed a course of oral . . . [Full Text of this Article]