PEDIATRICS Vol. 99 No. 3 March 1997, pp. 489-496
AMERICAN ACADEMY OF PEDIATRICS:
Revised Guidelines for Prevention of Early-onset Group B
Streptococcal (GBS) Infection
In 1992, the Committee on Infectious Diseases and Committee on Fetus and Newborn of the American Academy of Pediatrics provided guidelines for prevention of early-onset group B streptococcal (GBS) disease through intrapartum chemoprophylaxis of selected maternal GBS carriers. The guidelines were based on demonstrated efficacy in randomized, controlled clinical trials and selected only women with GBS colonization who had an obstetric risk factor. The guidelines were controversial and their implementation incomplete. Since 1992, additional data have become available, and experience with the guidelines has been gained in numerous medical centers. Recently, consensus guidelines were developed by obstetricians, pediatricians, family practitioners, and public health authorities and published by the Centers for Disease Control and Prevention. These recommendations are supported by the American College of Obstetricians and Gynecologists and the American Academy of Pediatrics. This statement reviews the selection of pregnant women for chemoprophylaxis and provides an algorithm for management of their newborns.
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|
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|
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|
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|
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|
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|
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|
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|
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 E. HERTING, X. GAN, P. RAUPRICH, C. JARSTRAND, and B. ROBERTSON Combined Treatment with Surfactant and Specific Immunoglobulin Reduces Bacterial Proliferation in Experimental Neonatal Group B Streptococcal Pneumonia Am. J. Respir. Crit. Care Med., June 1, 1999; 159(6): 1862 - 1867. [Abstract] [Full Text]
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|
|
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|
|
|
W. E. Benitz, J. B. Gould, and M. L. Druzin Risk Factors for Early-onset Group B Streptococcal Sepsis: Estimation of Odds Ratios by Critical Literature Review Pediatrics, June 1, 1999; 103(6): 77e - 77. [Abstract] [Full Text]
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N. Embleton, U. Wariyar, and E. Hey Mortality from early onset group B streptococcal infection in the United Kingdom Arch. Dis. Child. Fetal Neonatal Ed., March 1, 1999; 80(2): 139F - 141. [Abstract] [Full Text]
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D. ISAACS Prevention of early onset group B streptococcal infection: screen, treat, or observe? Arch. Dis. Child. Fetal Neonatal Ed., September 1, 1998; 79(2): 81F - 82. [Full Text]
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L. M Moses, P T Heath, A R Wilkinson, H E Jeffery, and D Isaacs Early onset group B streptococcal neonatal infection in Oxford 1985-96 Arch. Dis. Child. Fetal Neonatal Ed., September 1, 1998; 79(2): 148F - 149. [Abstract] [Full Text]
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 A. Schuchat Epidemiology of Group B Streptococcal Disease in the United States: Shifting Paradigms Clin. Microbiol. Rev., July 1, 1998; 11(3): 497 - 513. [Abstract] [Full Text] [PDF]
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M. Fernandez, M. E. Hickman, and C. J. Baker Antimicrobial Susceptibilities of Group B Streptococci Isolated between 1992 and 1996 from Patients with Bacteremia or Meningitis Antimicrob. Agents Chemother., June 1, 1998; 42(6): 1517 - 1519. [Abstract] [Full Text]
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D. L. Fenster;, N. A. Halsey, and W. Oh CDC/AAP/Group B Streptococcal Infections Pediatrics, January 1, 1998; 101(1): 158 - 158. [Full Text] [PDF]
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W. Oh and G. Merenstein Fourth Edition of the Guidelines for Perinatal Care: Summary of Changes Pediatrics, December 1, 1997; 100(6): 1021 - 1022. [Full Text] [PDF]
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A. Schuchat, K. Robinson, J. D. Wenger, L. H. Harrison, M. Farley, A. L. Reingold, L. Lefkowitz, B. A. Perkins, and The Active Surveillance Team Bacterial Meningitis in the United States in 1995 N. Engl. J. Med., October 2, 1997; 337(14): 970 - 976. [Abstract] [Full Text] [PDF]
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