PEDIATRICS Vol. 99 No. 3 March 1997, pp. 351-353 (doi:10.1542/peds.99.3.351)
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lee, C.-L.
Right arrow Articles by Ko, Y.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, C.-L.
Right arrow Articles by Ko, Y.-C.
Related Collections
Right arrow Infectious Disease & Immunity
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

PEDIATRICS Vol. 99 No. 3 March 1997, pp. 351-353

Hepatitis B Vaccination and Hepatocellular Carcinoma in Taiwan

Received Oct 9, 1995; accepted Apr 4, 1996.

Cheng-Liang Lee*, Dagger and Ying-Chin Ko§

From the * Department of Pediatrics, Kaohsiung Municipal Min Sheng Hospital, Kaohsiung, Taiwan; the Dagger  Institute of Medicine, Kaohsiung Medical College, Kaohsiung, Taiwan; and the § School of Public Health, Kaohsiung Medical College, Kaohsiung, Taiwan.

Objective.  In 1984, Taiwan started a large-scale hepatitis B vaccination program, enabling us to test the hypothesis that prevention of hepatitis B virus infection eventually decreases the incidence of hepatocellular carcinoma.

Methods.  Groups aged 0 to 9 years and 10 to 100 years in each calendar year were defined as the study group and the reference group, respectively. The percentage of children vaccinated in the study group increased during recent years. The study group and the reference group were divided into 5-year age strata (0 to 4, 5 to 9, ... , 80 to 84, and 85 and over). Poisson regression was used to estimate age- and gender-adjusted liver carcinoma mortality rate ratios for 1974 through 1993, relative to 1974.

Results.  The adjusted mortality rate ratios of liver carcinoma in the study group decreased significantly for 1992 and 1993, whereas in the reference group it did not show the same result. A significantly declining trend of liver carcinoma mortality rate ratios was observed in the study group after 1984, whereas the same trend was not found in the reference group.

Conclusions.  Our results support the hypothesis that hepatitis B vaccination can decrease the incidence of hepatocellular carcinoma.

Key words: hepatitis B virus, vaccine, hepatocellular carcinoma.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Epidemiol RevHome page
Y.-C. Chien, C.-F. Jan, H.-S. Kuo, and C.-J. Chen
Nationwide Hepatitis B Vaccination Program in Taiwan: Effectiveness in the 20 Years After It Was Launched
Epidemiol. Rev., August 1, 2006; 28(1): 126 - 135.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
R. Bhimma, H. M. Coovadia, M. Adhikari, and C. A. Connolly
The Impact of the Hepatitis B Virus Vaccine on the Incidence of Hepatitis B Virus-Associated Membranous Nephropathy
Arch Pediatr Adolesc Med, October 1, 2003; 157(10): 1025 - 1030.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Prevention of Cancer in the Next Millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research
Cancer Res., October 1, 1999; 59(19): 4743 - 4758.
[Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
F. J. Mahoney
Update on Diagnosis, Management, and Prevention of Hepatitis B Virus Infection
Clin. Microbiol. Rev., April 1, 1999; 12(2): 351 - 366.
[Abstract] [Full Text] [PDF]