PEDIATRICS Vol. 99 No. 1 January 1997,
p. e5
Copyright ©1997 by the American Academy of Pediatrics
ELECTRONIC ARTICLE:
Environmental Risk Factors Associated With Pediatric Idiopathic
Pulmonary Hemorrhage and Hemosiderosis in a Cleveland Community
Received Dec 28, 1995; accepted Apr 23, 1996.
,, and
From the * National Center for Environmental Health, Centers for
Disease Control and Prevention, Department of Health and Human
Services, Atlanta, Georgia; Cuyahoga County Board of Health,
Cleveland, Ohio; and § Rainbow Babies and Childrens Hospital,
Department of Pediatrics, Case Western Reserve School of Medicine,
Cleveland, Ohio.
Background. Unexplained pulmonary hemorrhage and hemosiderosis are rarely seen in infancy. A geographic cluster of 10 infants with this illness was identified in a large pediatric referral hospital in Cleveland, Ohio, during the period of January 1993 through December 1994. One infant died of severe respiratory failure.
Methods. A case-control study was conducted. Three control infants were matched by age with each case infant. All study infants' guardians were interviewed. Questions were asked about child care practices and home conditions for the period before case infants' illnesses. All infants' records were reviewed, their homes were visited, and a structural and environmental survey was conducted.
Results. All 10 case infants were black, and 9 were male,
whereas 50.0% of control infants were male, and 83.3% were black. The
case infants' mean age was 10.2 weeks (range, 6 weeks to 6 months).
Matched analysis demonstrated that case infants' homes were more
likely to have had water damage preceding the pulmonary hemorrhage
event (odds ratio, 16.25; 95% confidence interval, 2.55 to 
). Case
infants were also more likely to have had close relatives with
pulmonary hemorrhage (odds ratio, 33.14; 95% confidence interval, 5.10 to ). In addition, 50.0% of case infants experienced recurrent
pulmonary hemorrhaging after returning to their homes.
Conclusion. The results of this investigation of a cluster of infants with massive, acute pulmonary hemorrhage and hemosiderosis suggest that the affected infants may have been exposed to contaminants in their homes. Epidemiologic clues, such as water damage in the case infants' homes, suggest that environmental risk factors may contribute to pulmonary hemorrhage. pulmonary hemorrhage, hemosiderosis, infancy, indoor air pollution, pesticides, volatile organic compounds, cholinesterase.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. A. F. Tender, J. Janakiram, E. Arce, R. Mason, T. Jordan, J. Marsh, S. Kin, Jianping He, and R. Y. Moon Reasons for In-Hospital Formula Supplementation of Breastfed Infants From Low-Income Families J Hum Lact, February 1, 2009; 25(1): 11 - 17. [Abstract] [PDF]
|
|
|
|
 |
|
 J. B. Wolf Is Breast Really Best? Risk and Total Motherhood in the National Breastfeeding Awareness Campaign Journal of Health Politics Policy and Law, August 1, 2007; 32(4): 595 - 636. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Feldman-Winter Campaign promotes exclusive breastfeeding for 6 months AAP News, August 1, 2004; 25(2): 74 - 74. [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Leaf, P. L. Owens, J. M. Leventhal, B. W. C. Forsyth, M. Vaden-Kiernan, L. D. Epstein, A. W. Riley, and S. M. Horwitz Pediatricians' Training and Identification and Management of Psychosocial Problems Clinical Pediatrics, May 1, 2004; 43(4): 355 - 365. [Abstract] [PDF]
|
|
|
|
 |
|
 R. J. Schanler, K. G. O'Connor, and R. A. Lawrence Pediatricians' Practices and Attitudes Regarding Breastfeeding Promotion Pediatrics, March 1, 1999; 103(3): 35e - 35. [Abstract] [Full Text]
|
|
|
|
|
|
M. Thomasgard and V. Collins Collaborative Office Rounds Between Pediatricians and Child Psychiatrists Clinical Pediatrics, May 1, 1998; 37(5): 327 - 330. [PDF]
|
|
