PEDIATRICS Vol. 98 No. 3 September 1996, pp. 514
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Dexamethasone and Bronchopulmonary Dysplasia

Lee Frank MD, PhD1 and Paula Christina Lecuona PhD1

1 University of Miami School of Medicine, Pulmonary Research Center (R-120), Miami, FL 33101

With regard to the article by Jones et al entitled "Controlled Trial of Dexamethasone in Neonatal Chronic Lung Disease: A 3-Year Follow-Up" (Pediatrics. 1995;96:897-906), it is our belief that this randomized multi-center study showed no positive effect of dexamethasone (DEX) treatment in the neonates at 3 years after its use to try to reduce the incidence/severity of chronic O2-related lung disease or bronchopulmonary dysplasia (BPD).1 This summary of a large controlled trial (sim140 very low birth weight [VLBW] infants in the DEX and placebo groups) tends to support the subacute and chronic findings of many other trials of DEX therapy in VLBW premature infants with early-life severe respiratory distress syndrome.2-5




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